Dysoxylum binectariferum bark as a new source of anticancer drug camptothecin: Bioactivity-guided isolation and LCMS-based quantification

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 14, 2014, Pages 3146-3149

  Jain, Shreyans K ^a,b   Meena, Samdarshi ^a,b   Gupta, Ajai P ^a   Kushwaha, Manoj ^a   Uma Shaanker, R ^c   Jaglan, Sundeep ^a   Bharate, Sandip B ^b   Vishwakarma, Ram A ^a,b  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c UNIVERSITY OF AGRICULTURAL SCIENCES   (India)

Author keywords

9 Methoxy camptothecin; Anticancer; Camptothecin; Dysoxylum binectariferum; Quantification by LCMS; Rohitukine

Indexed keywords

CAMPTOTHECIN; HERBACEOUS AGENT; 9 METHOXY CAMPTOTHECIN; ANTINEOPLASTIC AGENT; PLANT EXTRACT; ROHITUKINE; UNCLASSIFIED DRUG;

ARTICLE; BARK; BIOASSAY; BIOLOGICAL ACTIVITY; CYTOTOXICITY; DRUG ISOLATION; DYSOXYLUM; DYSOXYLUM BINECTARIFERUM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINAL PLANT; MELIACEAE; NONHUMAN; PLANT LEAF; PLANT SEED; DRUG STRUCTURE; HUMAN; HUMAN CELL; CELL PROLIFERATION; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HL 60 CELL LINE; ISOLATION AND PURIFICATION; STRUCTURE ACTIVITY RELATION;

DYSOXYLUM; MELIACEAE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; MASS SPECTROMETRY; MELIACEAE; MOLECULAR CONFORMATION; PLANT BARK; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902545537     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.001     Document Type: Article

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