Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers

Nutrition Journal

Volumn 13, Issue 1, 2014, Pages

  Miyake, Mika ^a   Kirisako, Takayoshi ^a   Kokubo, Takeshi ^a   Miura, Yutaka ^a   Morishita, Koji ^b   Okamura, Hisayoshi ^c   Tsuda, Akira ^c  

^a KIRIN HOLDINGS CO LTD   (Japan)

^b KYOWA HAKKO BIO CO   (Japan)

^c KURUME UNIVERSITY   (Japan)

Author keywords

Clinical trial; L ornithine supplementation; Stress and sleep

Indexed keywords

HYDROCORTISONE; ORNITHINE; PLACEBO; PRASTERONE SULFATE;

ADULT; ANGER; ANXIETY DISORDER; ARTICLE; ATHENS INSOMNIA SCALE; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DREAMING; FATIGUE; HOSTILITY; HUMAN; HYDROCORTISONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MOOD; OGRI SHIRAKAWA AZUMI SLEEP; PROFILE OF MOOD STATES; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SEROLOGY; SLEEP QUALITY; SOMNOLENCE; STRESS; TENSION; AFFECT; BLOOD; DRUG EFFECTS; DRUG THERAPY; FEMALE; MALE; MENTAL STRESS; MIDDLE AGED; SLEEP;

ANIMALIA; OSA;

ADULT; AFFECT; DEHYDROEPIANDROSTERONE SULFATE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FATIGUE; FEMALE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; ORNITHINE; PLACEBOS; SLEEP; STRESS, PSYCHOLOGICAL;

EID: 84902545147     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-13-53     Document Type: Article

References (52)

1. Sleep habits and susceptibility to the common cold. Cohen S, Doyle WJ, Alper CM, Janicki-Deverts D, Turner RB, Arch Intern Med 2009 169 62 67 10.1001/archinternmed.2008.505 19139325
2. Coemergence of insomnia and a shift in the Th1/Th2 balance toward Th2 dominance. Sakami S, Ishikawa T, Kawakami N, Haratani T, Fukui A, Kobayashi F, Fujita O, Araki S, Kawamura N, Neuroimmunomodulation 2002 10 337 343 10.1159/000071474 12907840
3. Chronic insomnia and immune functioning. Savard J, Laroche L, Simard S, Ivers H, Morin CM, Psychosom Med 2003 65 211 221 10.1097/01.PSY.0000033126. 22740.F3 12651988
4. Effects of hormone therapy with estrogen and/or progesterone on sleep pattern in postmenopausal women. Hachul H, Bittencourt LR, Andersen ML, Haidar MA, Baracat EC, Tufik S, Int J Gynaecol Obstet 2008 103 207 212 10.1016/j.ijgo.2008.07.009 18812241
5. Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects. Irwin M, Clark C, Kennedy B, Christian Gillin J, Ziegler M, Brain Behav Immun 2003 17 365 372 10.1016/S0889-1591(03)00031-X 12946658
6. Disturbed sleep and fatigue as predictors of return from long-term sickness absence. Akerstedt T, Kecklund G, Selen J, Ind Health 2010 48 209 214 10.2486/indhealth.48.209 20424352
7. Karoshi-death from overwork: occupational health consequences of Japanese production management. Nishiyama K, Johnson JV, Int J Health Serv 1997 27 625 641 10.2190/1JPC-679V-DYNT-HJ6G 9399110
8. Subjective fatigue and stress hormone levels in urine according to duration of shiftwork. Park J, Ha M, Yi Y, Kim Y, J Occup Health 2006 48 446 450 10.1539/joh.48.446 17179637
9. Stress management and workplace disability in the US, Europe and Japan. Jones DL, Tanigawa T, Weiss SM, J Occup Health 2003 45 1 7 10.1539/joh.45.1 14605422
10. The reciprocal regulation of stress hormones and GABA(A) receptors. Mody I, Maguire J, Front Cell Neurosci 2012 6 4 22319473
11. Measuring cortisol in human psychobiological studies. Levine A, Zagoory-Sharon O, Feldman R, Lewis JG, Weller A, Physiol Behav 2007 90 43 53 10.1016/j.physbeh.2006.08.025 17055006
12. Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. Morley JE, Kaiser F, Raum WJ, Perry HM 3rd, Flood JF, Jensen J, Silver AJ, Roberts E, Proc Natl Acad Sci U S A 1997 94 7537 7542 10.1073/pnas.94.14.7537 9207127
13. Longitudinal changes in dehydroepiandrosterone concentrations in men and women. Nafziger AN, Bowlin SJ, Jenkins PL, Pearson TA, J Lab Clin Med 1998 131 316 323 10.1016/S0022-2143(98)90181-0 9579384
14. Clinical uses and misuses of dehydroepiandrosterone. Binello E, Gordon CM, Curr Opin Pharmacol 2003 3 635 641 10.1016/j.coph.2003.07.006 14644016
15. Influence of DHEA administration on 24-hour cortisol concentrations. Kroboth PD, Amico JA, Stone RA, Folan M, Frye RF, Kroboth FJ, Bigos KL, Fabian TJ, Linares AM, Pollock BG, Hakala C, J Clin Psychopharmacol 2003 23 96 99 10.1097/00004714-200302000-00014 12544381
16. Chronic stress and immunosenescence: a review. Bauer ME, Neuroimmunomodulation 2008 15 241 250 10.1159/000156467 19047801
17. Altered salivary dehydroepiandrosterone levels in major depression in adults. Michael A, Jenaway A, Paykel ES, Herbert J, Biol Psychiatry 2000 48 989 995 10.1016/S0006-3223(00)00955-0 11082473
18. Adrenal androgens and cortisol in major depression. Osran H, Reist C, Chen CC, Lifrak ET, Chicz-DeMet A, Parker LN, Am J Psychiatry 1993 150 806 809 8386908
19. Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients. Young AH, Gallagher P, Porter RJ, Am J Psychiatry 2002 159 1237 1239 10.1176/appi.ajp.159.7.1237 12091208
20. Orally administered L-ornithine reduces restraint stress-induced activation of the hypothalamic-pituitary-adrenal axis in mice. Kurata K, Nagasawa M, Tomonaga S, Aoki M, Akiduki S, Morishita K, Denbow DM, Furuse M, Neurosci Lett 2012 506 287 291 10.1016/j.neulet.2011.11.024 22133808
21. Influence of low-temperature processing of the brackish-water bivalve, Corbicula japonica, on the ornithine content of its extract. Uchisawa H, Sato A, Ichita J, Matsue H, Ono T, Biosci Biotechnol Biochem 2004 68 1228 1234 10.1271/bbb.68.1228 15215585
22. Proximate composition, free amino acids and peptides contents in commercial chicken and other meat essences. Wu H, Shiau C, J Food Drug Anal 2002 10 170 177
23. Fate of enterally administered ornithine in healthy animals: interactions with alpha-ketoglutarate. Vaubourdolle M, Jardel A, Coudray-Lucas C, Ekindjian OG, Agneray J, Cynober L, Nutrition 1989 5 183 187 2520285
24. Catabolism of Proteins and of Amino Acid Nitrogen. Rodwell V, Herper's Biochemistry. Chapter 31 New York: McGraw-Hill/Appleton & Lange, Murray R, Mayes P, Rodwell V, Granner D, 25 1999 313 322
25. Accumulation of amino acids by the perfused rat liver in the presence of ethanol. Krebs HA, Hems R, Lund P, Biochem J 1973 134 697 705 4749270
26. L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism. Sugino T, Shirai T, Kajimoto Y, Kajimoto O, Nutr Res 2008 28 738 743 10.1016/j.nutres.2008.08.008 19083482
27. Effect of L: -ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Demura S, Morishita K, Yamada T, Yamaji S, Komatsu M, Eur J Appl Physiol 2011 111 2837 2843 10.1007/s00421-011-1896-1 21431425
28. McNair P, Lorr M, Droppleman L, Profile of Mood States San Diego: Educational and Industrial Testing Service 1992
29. Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria. Soldatos CR, Dikeos DG, Paparrigopoulos TJ, J Psychosom Res 2000 48 555 560 10.1016/S0022-3999(00)00095-7 11033374
30. Standardization of revised version of OSA sleep inventory for middle age and aged. Yamamoto Y, Tanaka H, Takase M, Shirakawa S, Brain Sci Ment Disord 1999 10 401 409
31. Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress. Kurauchi I, Shigemi K, Kabuki Y, Hamasu K, Yamane H, Aoki M, Kawada Y, Morishita K, Denbow DM, Furuse M, Nutr Neurosci 2010 13 17 20 10.1179/147683010X12611460763481 20132650
32. L-ornithine attenuates corticotropin-releasing factor-induced stress responses acting at GABAA receptors in neonatal chicks. Kurata K, Shigemi K, Tomonaga S, Aoki M, Morishita K, Denbow DM, Furuse M, Neuroscience 2011 172 226 231 21056090
33. Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks. Suenaga R, Yamane H, Tomonaga S, Asechi M, Adachi N, Tsuneyoshi Y, Kurauchi I, Sato H, Denbow DM, Furuse M, Amino Acids 2008 35 107 113 10.1007/s00726-007-0617-x 18219550
34. Functional role of local GABAergic influences on the HPA axis. Cullinan WE, Ziegler DR, Herman JP, Brain Struct Funct 2008 213 63 72 10.1007/s00429-008-0192-2 18696110
35. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J, J Neurosci 2011 31 18198 18210 10.1523/JNEUROSCI.2560-11.2011 22171026
36. Natural steroids counteracting some actions of putative depressogenic steroids on the central nervous system: potential therapeutic benefits. Dubrovsky B, Med Hypotheses 1997 49 51 55 10.1016/S0306-9877(97)90252-8 9247908
37. Relationship of dehydroepiandrosterone and cortisol in disease. Hechter O, Grossman A, Chatterton RT Jr, Med Hypotheses 1997 49 85 91 10.1016/S0306-9877(97)90258-9 9247914
38. Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Goodyer IM, Herbert J, Altham PM, Pearson J, Secher SM, Shiers HM, Psychol Med 1996 26 245 256 10.1017/S0033291700034644 8685281
39. Elevation of the cortisol/dehydroepiandrosterone ratio in schizophrenia patients. Ritsner M, Maayan R, Gibel A, Strous RD, Modai I, Weizman A, Eur Neuropsychopharmacol 2004 14 267 273 10.1016/j.euroneuro.2003.09.003 15163435
40. Conversation about Change. Miller WR, Rollnick S, Motivational Interviewing. Chapter 1 New York: Guilford Press, Miller WR, Rollnick S, 2012 3 13
41. Defining and Comparing the Psychotherapies. Prochaska JO, Norcross JC, Systems of Psychotherapy. Chapter 1 Belmont: Thompson, Prochaska JO, Norcross JC, 2007 1 24
42. Working with new technologies: hormone excretion as an indicator for sustained arousal. A pilot study. Korunka C, Huemer KH, Litschauer B, Karetta B, Kafka-Lutzow A, Biol Psychol 1996 42 439 452 10.1016/0301-0511(95)05172-4 8652758
43. L-ornithine-L-aspartate improves alcohol-derived fatigue feeling in flushers. Kokubo T, Ikeshima E, Komatsu M, Kirisako T, Miura Y, Horiuchi M, Tsuda A, Jpn Pharmachol Ther 2012 40 205 212
44. Promotion of non-rapid eye movement sleep in mice after oral administration of ornithine. Omori K, Kagami Y, Yokoyama C, Moriyama T, Matsumoto N, Masaki M, Nakamura H, Kamasaka H, Shiraishi K, Kometani T, Kuriki T, Huang ZL, Urade Y, Sleep Biol Rhythms 2012 10 38 45 10.1111/j.1479-8425.2011. 00515.x
45. The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise. Demura S, Yamada T, Yamaji S, Komatsu M, Morishita K, Eur J Clin Nutr 2010 64 1166 1171 10.1038/ejcn.2010.149 20717126
46. Ornithine-alpha-ketoglutarate (OKG) supplementation is more effective than its component salts in traumatized rats. Jeevanandam M, Holaday NJ, Petersen SR, J Nutr 1996 126 2141 2150 8814202
47. Interrelations between sleep and the somatotropic axis. Van Cauter E, Plat L, Copinschi G, Sleep 1998 21 553 566 9779515
48. Growth hormone and cortisol secretion in relation to sleep and wakefulness. Davidson JR, Moldofsky H, Lue FA, J Psychiatry Neurosci 1991 16 96 102 1911740
49. Effect of alcohol on sleep and nighttime plasma growth hormone and cortisol concentrations. Prinz PN, Roehrs TA, Vitaliano PP, Linnoila M, Weitzman ED, J Clin Endocrinol Metab 1980 51 759 764 10.1210/jcem-51-4-759 7419664
50. Correlation between breakfast tryptophan content and morning-evening in Japanese infants and students aged 0-15 yrs. Harada T, Hirotani M, Maeda M, Nomura H, Takeuchi H, J Physiol Anthropol 2007 26 201 207 10.2114/jpa2.26.201 17435366
51. Sleep, serotonin, and suicide in Japan. Kohyama J, J Physiol Anthropol 2011 30 1 8 10.2114/jpa2.30.1 21307614
52. Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age. Paredes SD, Marchena AM, Bejarano I, Espino J, Barriga C, Rial RV, Reiter RJ, Rodriguez AB, J Gerontol A Biol Sci Med Sci 2009 64 340 350 19211547