Natural steroids counteracting some actions of putative depressogenic steroids on the central nervous system: Potential therapeutic benefits

Medical Hypotheses

Volumn 49, Issue 1, 1997, Pages 51-55

  Dubrovsky, B ^a  

^a Allan Memorial Institute   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA,17BETA DIHYDROXY 6 METHYL 17ALPHA (1 PROPYNYL)ANDROSTA 1,4,6 TRIEN 3 ONE; ALDOSTERONE; AMINOGLUTETHIMIDE; CORTICOTROPIN; DEXAMETHASONE; KETOCONAZOLE; METYRAPONE; MIFEPRISTONE; OXPRENOATE POTASSIUM; PRASTERONE SULFATE;

ANIMAL MODEL; CLINICAL TRIAL; CORTICOTROPIN RELEASE; CUSHING DISEASE; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; HORMONE INHIBITION; HUMAN; HYPERTENSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LONG TERM POTENTIATION; MEMORY; MENTAL DISEASE; NEUROENDOCRINE DISEASE; NONHUMAN; PRIORITY JOURNAL; RASH; RAT; REVIEW;

ANIMALIA; ASTEROIDEA;

EID: 0030883903     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(97)90252-8     Document Type: Article

References (78)

1. Dubrovsky B, Filipini D L, Gijsbers K, Birmingham M K. Early and late effects of steroid hormones on the nervous system. In: Simmonds M A, ed. Steroids and Neuronal Activity: Ciba Foundation Symposium 153. Chichester: Wiley, 1990: 240-257.
2. Dubrovsky B. Hyperactivity of adrenal cortex and depressive disorders: concomitant psychological manifestations or causally related symptoms. Med Hypotheses 1991; 36: 1761-1766.
3. Ghadirian M A, Engelsman F, Dhar V et al. The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment. Biol Psychiatry 1995; 37: 369-375.
4. Gifford S, Gunderson J G. Cushing's disease as a psychosomatic disorder: a selective view of clinical and experimental literature and a report of ten cases. Perspect Biol Med 1970; (Winter): 169-221.
5. Jeffcoate W J, Silverstone J T, Edwards C R, Besser G M. Psychiatric manifestations of Cushing's syndrome: response to lowering of plasma cortisol. Q J Med 1979; 48: 465-472.
6. Kathol R G. Etiologic implications of corticosteroid changes in affective disorder. Psychiatric Med 1985; 3: 135-162.
7. Kelly W F, Checkley S A, Bender D A, Mashiter K. Cushing's syndrome and depression: a prospective study of 26 patients. Br J Psychiatry 1983; 142: 16-19.
8. Quarton G C, Clark L D, Cobb S, Bauer W. Mental disturbances associated with ACTH and cortisone: a review of explanatory hypotheses. Medicine 1955; 34: 13-50.
9. Schatzberg A F, Rothschild A J, Langlais P J, Bird E D, Cole J O. A corticosteroid/dopamine hypothesis for psychotic depression and related states. J Psychiatric Res 1985; 19: 57-64.
10. Editorial: Depression and Cushing's syndrome. Lancet 1986; September 6: 550-551.
11. Wolkowitz O M, Reus V I, Weingartner H. Cognitive effects of corticosteroids. Am J Psychiatry 1990; 147: 1297-1303.
12. Cushing H. Psychiatric disturbance associated with disorders of the ductless glands. Am J Insanity 1913; 69: 965-990.
13. Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations. Bull John Hopkins Hosp 1932; 50: 137-195.
14. Kramlinger K G, Peterson G C, Watson P K, Lazaro L L. Metyrapone for depression and delirium secondary to Cushing's syndrome. Psychosomatics 1985; 26: 67-71.
15. Price L H, Mahson R T, McDougle C, Pelton G H. Antiglucocorticoids as treatments for depression: rationale for use and therapeutic potentials. CNS Drugs 1996; 5: 311-320.
16. Ravaris C L, Sateia M J, Beroza K W, Noordsy D L, Brinck-Johnsen T. Effect of ketoconazole on a hyphophysectomized, hypercortisolemic, psychotically depressed woman. Arch Gen Psychiatry 1988; 45: 957-966.
17. Krishnan K R R. Pituitary and adrenal changes in depression. Psychiatric Ann 1993; 23: 671-675.
18. Starkman N M, Schteingart D E, Schork M A. Depressed mood and other psychiatric manifestations of Cushing's syndrome relationship to hormone levels. Psychosomatic Med 1981; 43: 3-18.
19. Starkman N M. The HPA axis and psychopathology of Cushing's syndrome. Psychiatric Ann 1993; 23: 691-701.
20. Murphy B E P, Filipini D, Ghadirian M A. Possible use of glucocorticoid receptor antagonists in the treatment of major depression: preliminary results using RU 486. J Psychiatry Neurosci 1993; 18: 209-213.
21. Selye H. Confusion and controversy in the stress field. J Human Stress 1975; 1: 37.
22. Dubrovsky B, Yoo A, Harris J. Electrophysiological effects of steroid hormones on nervous systems. In: Stone T, ed. CNS Neurotransmitters and Neuromodulators: Neuroactive Steroids. Boca Raton, Fl: CRC Press, 1996: 89-102.
23. Van den Berg D T W M, de Kloet E R, van Dijken H H, de Jong W. Differential central effects of mineralocorticoid and glucocorticoid agonists and antagonists on blood pressure. Endocrinology 1990; 126: 118-126.
24. Mason J W. Specificity in the organization of neuroendocrine response profiles. In: Seeman P, Brown G, eds. Frontiers in Neurology and Neuroscience Research. Toronto: University of Toronto Press, 1974: 68.
25. Rothschild A J. The dexamethasone suppression test in psychiatric disorders. Psychiatric Ann 1993; 23: 662-670.
26. Sapolsky R M, Plotsky P M. Hypercortisolemism and its possible neural bases. Biol Psychol 1990; 27: 937.
27. Wolkowitz O M, Rubinow D, Doran A R et al. Prednisone effects on neurochemistry and behavior. Arch Gen Psychiatry 1990; 47: 963-968.
28. Drake F R. Neuropsychiatric-like symptomatology of Addison's disease: a review. Am J Med Sci 1968; 71: 106-113.
29. Starkman N M, Schteingart D E, Schork M A. Cushing's syndrome after treatment: changes in cortisol and ACTH levels and amelioration of the depressive syndrome. Psychiatric Res 1986; 19: 177-188.
30. Dubrovsky B, Liquornik M, Noble P, Gijsbers K. Effects of 5α-dihydrocorticosterone on evoked potentials and long term potentiation. Brain Res Bull 1987; 19: 635.
31. Dubrovsky B, Gijsbers K, Filipini D L, Birmingham M K. Effects of adrenocortical steroids on long-term potentiation in the limbic system: basic mechanisms and behavioral consequences. Cell Mol Neurobiol 1993; 13: 399-414.
32. Lynch G, Staubli V. Possible contributions of long-term potentiation to the encoding and organization of memory. Brain Res 1991; 16: 204-206.
33. Pavlides C, Watanabe Y, McEwen B S. Effects of glucocorticoids on hippocampal long term potentiation. Hippocampus 1993; 3: 183-192.
34. Pavlides C, Watanabe Y, Magarinos A M, McEwen B S. Opposing rules of type I and type II adrenal steroid receptors in hippocampal long term potentiation. Neuroscience 1995; 68: 387.
35. Edelman G M. Neural Darwinism: The Theory of Neuronal Group Selection. New York: Basic Books, 1987.
36. Arbel I, Kadar T. Gilberman M, Levy A. The effects of long-term corticosterone administration on hippocampal morphology and cognitive performance of middle-aged rats. Brain Res 1994; 657: 222-235.
37. Reus VI. Hormonal mediation of memory disorder in depression. Drug Devel Res 1984; 4: 489-500.
38. Rubinow D R, Post R M, Savard R, Gold P W. Cortisol hypersecretion and cognitive impairment in depression. Arch Gen Psychiatry 1984; 41: 279-383.
39. Dunbar G C, Lishman W A. Depression, recognition-memory and hedonic tone: a signal detection analysis. Br J Psychiatry 1984; 144: 365-382.
40. Lishman W A. Selective factors in memory. Part 2: affective disorder. Psychol Med 1972; 2: 248-253.
41. Lishman W A. The speed of recall of pleasant and unpleasant experiences. Psychol Med 1974; 4: 212-218.
42. Lloyd G G, Lloyd W A. Effects of depression on the speed of recall of pleasant and unpleasant experiences. Psychol Med 1975; 5: 173-180.
43. Newcomer J W, Craft S, Hershey T, Askins K, Bardgett M E. Glucocorticoid-induced impairment in adult humans. J Neurosci 1994; 14: 2047-2053.
44. Mandler G. Recognizing: the judgement of previous occurrence. Psychol Rev 1980; 87: 252-271.
45. Squire L R. Memory and Brain. Oxford: Oxford University Press, 1987.
46. Filipini D L, Birmingham M K, Kraulis I, Gijsbers K, Dubrovsky B. Modulatory actions of adrenal steroids on limbic structures. J Steroid Biochem Mol Biol 1991; 39: 245-252.
47. Filipini D, Gijsbers K, Birmingham M K, Dubrovsky B. Effects of adrenal steroids and their reduced metabolites on hippocampal long-term potentiation. J Steroid Biochem Mol Biol 1991; 40: 87-92.
48. Bennet M C, Diamond D M, Fleshner M, Rose G M. Serum corticosterone level predicts the magnitude of hippocampal primed burst potentiation and depression in urethane-anesthetized rats. Psychobiology 1991; 19: 301-307.
49. Dubrovsky B. Evolution of nervous systems and psychiatry: consequences of the vertical and horizontal duality of the evolutionary process. J Psychiatry Neurosci 1993; 18: 245-259.
50. Dubrovsky B. Fundamental neuroscience and the classification of psychiatric disorders. Neurosci Biobehav Rev 1995; 19: 511-518.
51. Bower G H. Affect and cognition. Phil Trans Roy Soc London B 1983; 302: 387-402.
52. Teasdale J D. Negative thinking in depression: cause, effect or reciprocal relationship? Adv Behav Ther Res 1983; 5: 3-25.
53. Teasdale J D. Affect and accessibility. Phil Trans Roy Soc London B 1983; 302: 403-412.
54. Backstrom T, Landgren A, Zetterlund, Blom S, Dubrovsky B, Bixo M, Sodergard H. Effects of ovarian steroid hormones on brain excitability and their relation to epilepsy seizure variation during the menstrual cycle. In: Porter R, ed. Advances in Epileptology, Vol. XV. New York: Raven Press, 1984: 269-277.
55. Backstrom T, Bixo M, Dubrovsky B, Landgren S, Wahlstrom G. Brain excitability, steroid hormone and menstrual cycle. In: Dennerstein L, Fraser I, eds. Hormone and Behavior. Amsterdam: Elsevier, 1986.
56. Dubrovsky B, Williams D, Kraulis I. Effects of deoxycorticosterone and its Ring A reduced metabilites on the central nervos system. Exp Neurol 1982; 78: 728-739.
57. Dubrovsky B, Williams D, Kraulis I. Effects of corticosterone and 5α dihydrocorticosterone on brain excitability in the rat. J Neurosci Res 1985; 14: 118-127.
58. Dubrovsky B, Illes J, Birmingham M K. Effects of 18-hydroxydeoxycorticosterone on central nervous system excitability. Experientia 1986; 42: 1027.
59. Dubrovsky B. Adrenal steroids and the pathophysiology of a subset of depressive patients. J Psychiatry Neurosci 1993; 18: 1-13.
60. Elliott E M, Sapolsky R M. Corticosterone impairs hippocampal neuronal calcium regulation - possible mediating mechanism. Brain Res 1993; 602: 84.
61. Kraulis I, Foldes G. Dubrovsky B, Traikov H, Birmingham M. Distribution, metabolism and biological activity of deoxycorticosterone in rat central nervous system. Brain Res 1975; 88: 1.
62. Landgren S, Backstrom T, Dubrovsky B. The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex. Acta Physiol Scand 1987; 131: 33-42.
63. Roberts E, Bologa L, Flood J F, Smith G E. Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory of mice. Brain Res 1987; 406: 357-362.
64. Schumacher M. Rapid membrane effects of steroid hormones: an emerging concept in neuroendocrinology. Trends Neurosci 1990; 13: 359-362.
65. Yoo A, Harris J, Dubrovsky B. Dose response study of dehydroepiandrosterone sulfate on dentate gyrus LTP. Exp Neurol 1996; 137: 151-156.
66. Shafogoj Y, Opoku J, Qureshi D, Regelson W, Kalimi M. Dehydroepiandrosterone prevents dexamethasone-induced hypertension in rats. Am J Physiol 1992; 263: E210-E213.
67. Klyne W. The Chemistry of the Steroids. London: Methuen, 1965.
68. Flood J F, Roberts E. Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res 1988; 448: 178-181.
69. Roberts E. Guides through the labyrinth of AD: dehydroepiandrosterone, potassium channels and the C4 component of complement. In: Crook T, Bartus R T, Ferris S, Gershon S, eds. Treatment Development Strategies for Alzheimer's Disease. Madison, CT: Prowley, 1986.
70. Barnes C. Normal aging regionally specific changes in hippocampal synaptic transmission. Trends Neurosci 1994; 17: 13-18.
71. Jung-Testa I, Hu Z, Baulieu EE, Robel P. Neurosteroids: Biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 1989; 125: 2083-2091.
72. Majewska M D. Neurosteroids: endogenous bimodal modulators of the GABAA receptor: mechanisms of action and physiological significance. Progress Neurobiol 1992; 38: 379.
73. ffrench-Mullen J M H, Danks P, Spence K. Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism. J Neurosci 1994; 14: 1963-1977.
74. ffrench-Mullen J M H. Cortisol inhibition of calcium currents in guinea pig hippocampal CA1 neurons via G protein coupled activation of Protein Kinase C. J Neurosci 1995; 15: 903-911.
75. Yen T T, Allan J A, Pearson D V, Acton J M, Greenberg M M. Prevention of obesity in A vy/a mice by dehydroepiandrosterone. Lipids 1977; 12: 409-413.
76. ++ conductances: relevance to brain aging. Proc Natl Acad Sci USA 1992; 89: 8527.
77. Talmi M, Carlier E, Soumireu-Mourat B. Similar effects of aging and corticosterone treatment on mouse hippocampal function. Neurobiol Aging 1993; 14: 239.
78. Thibault O, Landfield P W. Increase in single L-type calcium channels in hippocampal neurons during aging. Science 1996; 272: 1017-1020.