Sperm protamine mRNA ratio and DNA fragmentation index represent reliable clinical biomarkers for men with varicocele after microsurgical varicocele ligation

Journal of Urology

Volumn 192, Issue 1, 2014, Pages 170-176

  Ni, Kai ^a,b   Steger, Klaus ^b   Yang, Hao ^a   Wang, Hongxiang ^a   Hu, Kai ^a   Chen, Bin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

DNA fragmentation index; infertility; male; protamines; testis; varicocele

Indexed keywords

BIOLOGICAL MARKER; MESSENGER RNA; PRM1 PROTEIN, HUMAN; PROTAMINE; PROTAMINE P2; COMPLEMENTARY DNA; PROTAMINE 1; PROTAMINE 2; UNCLASSIFIED DRUG;

ADULT; CHEMISTRY; COMPLICATION; DNA FRAGMENTATION; GENETICS; HUMAN; INFERTILITY, MALE; LIGATION; MALE; MALE GENITAL SYSTEM SURGERY; MICROSURGERY; PROCEDURES; PROSPECTIVE STUDY; REPRODUCIBILITY; SPERM; VARICOCELE; ARTICLE; ASTHENOSPERMIA; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; NORMAL VALUE; OLIGOSPERMIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; VARICOCELECTOMY;

ADULT; BIOLOGICAL MARKERS; DNA FRAGMENTATION; HUMANS; INFERTILITY, MALE; LIGATION; MALE; MICROSURGERY; PROSPECTIVE STUDIES; PROTAMINES; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SEMEN; UROLOGIC SURGICAL PROCEDURES, MALE; VARICOCELE;

EID: 84902533263     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2014.02.046     Document Type: Article

References (30)

1. S.H. Greenberg, L.I. Lipshultz, and A.J. Wein Experience with 425 subfertile male patients J Urol 119 1978 507
2. L. Dubin, and R.D. Amelar Varicocelectomy: 986 cases in a twelve-year study Urology 10 1977 446
3. R. Smith, H. Kaune, and D. Parodi et al. Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress Hum Reprod 21 2006 986
4. A. Zini, R. Azhar, and A. Baazeem et al. Effect of microsurgical varicocelectomy on human sperm chromatin and DNA integrity: a prospective trial Int J Androl 34 2011 14
5. V.W. Aoki, S.I. Moskovtsev, and J. Willis et al. DNA integrity is compromised in protamine-deficient human sperm J Androl 26 2005 741
6. A. Agarwal, and T.M. Said Role of sperm chromatin abnormalities and DNA damage in male infertility Hum Reprod Update 9 2003 331
7. K. Steger Haploid spermatids exhibit translationally repressed mRNAs Anat Embryol (Berl) 203 2001 323
8. L. Nanassy, L. Liu, and J. Griffin et al. The clinical utility of the protamine 1/protamine 2 ratio in sperm Protein Pept Lett 18 2011 772
9. K. Steger, K. Pauls, and T. Klonisch et al. Expression of protamine-1 and -2 mRNA during human spermiogenesis Mol Hum Reprod 6 2000 219
10. N. Rogenhofer, T. Dansranjavin, and M. Schorsch et al. The sperm protamine mRNA ratio as a clinical parameter to estimate the fertilizing potential of men taking part in an ART programme Hum Reprod 28 2013 969
11. R. Oliva Protamines and male infertility Hum Reprod Update 12 2006 417
12. B.N. Hendin, P.N. Kolettis, and R.K. Sharma et al. Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity J Urol 161 1999 1831
13. L. Simon, J. Castillo, and R. Oliva et al. Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes Reprod Biomed Online 23 2011 724
14. A. Garcia-Peiro, J. Martinez-Heredia, and M. Oliver-Bonet et al. Protamine 1 to protamine 2 ratio correlates with dynamic aspects of DNA fragmentation in human sperm Fertil Steril 95 2011 105
15. C. Cho, H. Jung-Ha, and W.D. Willis et al. Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice Biol Reprod 69 2003 211
16. L. Dubin, and R.D. Amelar Varicocele size and results of varicocelectomy in selected subfertile men with varicocele Fertil Steril 21 1970 606
17. D. Evenson, and L. Jost Sperm chromatin structure assay is useful for fertility assessment Methods Cell Sci 22 2000 169
18. M.H. Schlesinger, I.F. Wilets, and H.M. Nagler Treatment outcome after varicocelectomy. A critical analysis Urol Clin North Am 21 1994 517
19. S.P. Greenfield, P. Seville, and J. Wan Experience with varicoceles in children and young adults J Urol 168 2002 1684
20. J.P. Jarow, I.D. Sharlip, and A.M. Belker et al. Best practice policies for male infertility J Urol 167 2002 2138
21. A. Jungwirth, A. Giwercman, and H. Tournaye et al. European Association of Urology guidelines on male infertility: the 2012 update Eur Urol 62 2012 324
22. C. Krausz Male infertility: pathogenesis and clinical diagnosis Best Pract Res Clin Endocrinol Metab 25 2011 271
23. M. Bungum, P. Humaidan, and A. Axmon et al. Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome Hum Reprod 22 2007 174
24. M. Smit, J.C. Romijn, and M.F. Wildhagen et al. Decreased sperm DNA fragmentation after surgical varicocelectomy is associated with increased pregnancy rate J Urol 183 2010 270
25. M. Sergerie, G. Laforest, and L. Bujan et al. Sperm DNA fragmentation: threshold value in male fertility Hum Reprod 20 2005 3446
26. D.P. Evenson, and R. Wixon Data analysis of two in vivo fertility studies using Sperm Chromatin Structure Assay-derived DNA fragmentation index vs. pregnancy outcome Fertil Steril 90 2008 1229
27. V.W. Aoki, L. Liu, and K.P. Jones et al. Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability Fertil Steril 86 2006 1408
28. V.W. Aoki, L. Liu, and D.T. Carrell A novel mechanism of protamine expression deregulation highlighted by abnormal protamine transcript retention in infertile human males with sperm protamine deficiency Mol Hum Reprod 12 2006 41
29. C. Cho, W.D. Willis, and E.H. Goulding et al. Haploinsufficiency of protamine-1 or -2 causes infertility in mice Nat Genet 28 2001 82
30. C.L. Barratt, R.J. Aitken, and L. Bjorndahl et al. Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications - a position report Hum Reprod 25 2010 824