Porcine blood and surrogate markers do not prove benefit of aDabi-Fab

Critical Care

Volumn 18, Issue 3, 2014, Pages

  Connors, Nicholas J ^a   Gill, Justin ^b   Nakanishi, Allison ^b   Hoffman, Robert S ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DABIGATRAN; BENZIMIDAZOLE DERIVATIVE; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING FACTOR 7A; IMMUNOGLOBULIN F(AB) FRAGMENT; PYRIDINE DERIVATIVE;

BLEEDING; BLOOD CLOTTING DISORDER; BLOOD SAMPLING; DISEASE MARKER; DISEASE MODEL; DRUG INDUCED DISEASE; EX VIVO STUDY; HEMORRHAGIC SHOCK; HUMAN; LETTER; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PORCINE MODEL; PRIORITY JOURNAL; SURVIVAL; SWINE; ANIMAL;

ANIMALS; BENZIMIDAZOLES; BLOOD COAGULATION FACTORS; FACTOR VIIA; FACTOR XA INHIBITORS; IMMUNOGLOBULIN FAB FRAGMENTS; PYRIDINES;

EID: 84902524176     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13927     Document Type: Letter

References (4)

1. Grottke O, van Ryn J, Spronk HM, Rossaint R. Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model. Crit Care 2014, 18:R27. 10.1186/cc13717, 24499559.
2. Dager WE, Gosselin RC, Kitchen S, Dwyre D. Dabigatran effects of the international normalized ratio, activated partial thromboplastin time, thrombin time, and fibrinogen: a multicenter, in vitro study. Ann Pharmacother 2012, 46:1627-1636. 10.1345/aph.1R179, 23232017.
3. Pragst I, Zeitler SH, Doerr B, Kaspereit FJ, Herzog E, Dickneite G, van Ryn J. Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model. J Thromb Haemost 2012, 10:1841-1848. 10.1111/j.1538-7836.2012.04859.x, 22812619.
4. Honickel M, van Ryn J, Spronk HM, Ten Cate H, Rossaint R, Grottke O. Prothrombin complex concentrate restores haemostasis in a dabigatran anticoagulated polytrauma pig model. Crit Care 2014, 18:S40.