Morphological changes of cerebral vessels and expression patterns of MMP-2 and MMP-9 on cerebrovascular wall of alcoholic rats

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 5, 2014, Pages 1880-1888

  Qi, Qian ^a   Liu, Xia ^a   Zhang, Guozhong ^a   He, Wenjing ^a   Ma, Rufei ^a   Cong, Bin ^a   Li, Yingmin ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Alcohol abuse; Basilar artery; MMP 2; MMP 9; Remodeling

Indexed keywords

GELATINASE A; GELATINASE B; MMP2 PROTEIN, HUMAN; MMP2 PROTEIN, RAT; MMP9 PROTEIN, HUMAN; MMP9 PROTEIN, RAT;

ALCOHOLISM; ANIMAL; BASILAR ARTERY; BLOOD PRESSURE; BRAIN; CAPILLARY; CELL CULTURE; CEREBROVASCULAR DISORDERS; COMPLICATION; DISEASE MODEL; DRINKING BEHAVIOR; ENDOTHELIUM CELL; ENZYMOLOGY; HUMAN; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; TIME; ULTRASTRUCTURE; VASCULAR REMODELING; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; BASILAR ARTERY; BLOOD PRESSURE; BRAIN; CAPILLARIES; CELLS, CULTURED; CEREBROVASCULAR DISORDERS; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VASCULAR REMODELING;

EID: 84902459593     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Jimenez M, Chiuve SE, Glynn RJ, Stampfer MJ, Camargo CA Jr, Willett WC, Manson JE and Rexrode KM. Alcohol consumption and risk of stroke in women. Stroke 2012; 43: 939-945.
2. Ikehara S, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Inoue M and Tsugane S. Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: the Japan Public Health Center-based prospective study. Prev Med 2013; 57: 505-510.
3. Rantakomi SH, Laukkanen JA, Sivenius J, Kauhanen J and Kurl S. Alcohol consumption and the risk of stroke among hypertensive and overweight men. J Neurol 2013; 260: 534-539.
4. Anderson C, Ni Mhurchu C, Scott D, Bennett D, Jamrozik K and Hankey G. Triggers of subarachnoid hemorrhage: role of physical exertion, smoking, and alcohol in the Australasian Cooperative Research on Subarachnoid Hemorrhage Study (ACROSS). Stroke 2003; 34: 1771-1776.
5. Gundersen H, van Wageningen H and Gruner R. Alcohol-induced changes in cerebral blood flow and cerebral blood volume in social drinkers. Alcohol Alcohol 2013; 48: 160-165.
6. Trim RS, Simmons AN, Tolentino NJ, Hall SA, Matthews SC, Robinson SK, Smith TL, Padula CB, Paulus MP, Tapert SF and Schuckit MA. Acute ethanol effects on brain activation in low- and high-level responders to alcohol. Alcohol Clin Exp Res 2010; 34: 1162-1170.
7. Husain K, Vazquez-Ortiz M and Lalla J. Down regulation of aortic nitric oxide and antioxidant systems in chronic alcohol-induced hypertension in rats. Hum Exp Toxicol 2007; 26: 427-434.
8. Husain K, Mejia J, Lalla J and Kazim S. Dose response of alcohol-induced changes in BP, nitric oxide and antioxidants in rat plasma. Pharmacol Res 2005; 51: 337-343.
9. Haorah J, Knipe B, Leibhart J, Ghorpade A and Persidsky Y. Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. J Leukoc Biol 2005; 78: 1223-1232.
10. Haorah J, Schall K, Ramirez SH and Persidsky Y. Activation of protein tyrosine kinases and matrix metalloproteinases causes blood-brain barrier injury: Novel mechanism for neurodegeneration associated with alcohol abuse. Glia 2008; 56: 78-88.
11. Kuhlmann CR, Li F, Ludders DW, Schaefer CA, Most AK, Backenkohler U, Neumann T, Tillmanns H, Waldecker B, Erdogan A and Wiecha J. Dose-dependent activation of Ca2+-activated K+ channels by ethanol contributes to improved endothelial cell functions. Alcohol Clin Exp Res 2004; 28: 1005-1011.
12. Li W, Li J, Liu W, Altura BT and Altura BM. Alcohol- induced apoptosis of canine cerebral vascular smooth muscle cells: role of extracellular and intracellular calcium ions. Neurosci Lett 2004; 354: 221-224.
13. Masuda H, Zhuang YJ, Singh TM, Kawamura K, Murakami M, Zarins CK and Glagov S. Adaptive remodeling of internal elastic lamina and endothelial lining during flow-induced arterial enlargement. Arterioscler Thromb Vasc Biol 1999; 19: 2298-2307.
14. Spencer JA, Hacker SL, Davis EC, Mecham RP, Knutsen RH, Li DY, Gerard RD, Richardson JA, Olson EN and Yanagisawa H. Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proc Natl Acad Sci U S A 2005; 102: 2946-2951.
15. Karnik SK, Brooke BS, Bayes-Genis A, Sorensen L, Wythe JD, Schwartz RS, Keating MT and Li DY. A critical role for elastin signaling in vascular morphogenesis and disease. Development 2003; 130: 411-423.
16. Zahradka P, Harding G, Litchie B, Thomas S, Werner JP, Wilson DP and Yurkova N. Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP. Am J Physiol Heart Circ Physiol 2004; 287: H2861-2870.
17. Fonck E, Feigl GG, Fasel J, Sage D, Unser M, Rufenacht DA and Stergiopulos N. Effect of aging on elastin functionality in human cerebral arteries. Stroke 2009; 40: 2552-2556.
18. Goto Y, Hojo M, Yamagata S and Kikuta K. Fatal bleeding from arterial dissection after clipping of a ruptured aneurysm--case report. Neurol Med Chir (Tokyo) 2003; 43: 608-611.
19. Briones AM, Gonzalez JM, Somoza B, Giraldo J, Daly CJ, Vila E, Gonzalez MC, McGrath JC and Arribas SM. Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling. J Physiol 2003; 552: 185-195.
20. Arribas SM, Hinek A and Gonzalez MC. Elastic fibres and vascular structure in hypertension. Pharmacol Ther 2006; 111: 771-791.
21. Aiello VD, Gutierrez PS, Chaves MJ, Lopes AA, Higuchi ML and Ramires JA. Morphology of the internal elastic lamina in arteries from pulmonary hypertensive patients: a confocal laser microscopy study. Mod Pathol 2003; 16: 411-416.
22. Liu SQ. Alterations in structure of elastic laminae of rat pulmonary arteries in hypoxic hypertension. J Appl Physiol (1985) 1996; 81: 2147-2155.
23. Partridge CR, Sampson HW and Forough R. Long-term alcohol consumption increases matrix metalloproteinase-2 activity in rat aorta. Life Sci 1999; 65: 1395-1402.
24. Wang H, Yu X, Xu G, Gao G and Xu X. Alcoholism and traumatic subarachnoid hemorrhage: an experimental study on vascular morphology and biomechanics. J Trauma 2011; 70: E6-12.
25. Sell DR and Monnier VM. Molecular basis of arterial stiffening: role of glycation - a mini-review. Gerontology 2012; 58: 227-237.
26. Silvello D, Narvaes LB, Albuquerque LC, Forgiarini LF, Meurer L, Martinelli NC, Andrades ME, Clausell N, dos Santos KG and Rohde LE. Se-Serum levels and polymorphisms of matrix metalloproteinases (MMPs) in carotid artery atherosclerosis:higher MMP-9 levels are associated with plaque vulnerability. Biomarkers 2014; 19: 49-55.
27. Napoli C. MMP inhibition and the development of cerebrovascular atherosclerosis: The road ahead. Stroke 2002; 33: 2864-2865.
28. Pradhan-Palikhe P, Vikatmaa P, Lajunen T, Palikhe A, Lepantalo M, Tervahartiala T, Salo T, Saikku P, Leinonen M, Pussinen PJ and Sorsa T. Elevated MMP-8 and decreased myeloperoxidase concentrations associate significantly with the risk for peripheral atherosclerosis disease and abdominal aortic aneurysm. Scand J Immunol 2010; 72: 150-157.
29. Tarin C, Gomez M, Calvo E, Lopez JA and Zaragoza C. Endothelial nitric oxide deficiency reduces MMP-13-mediated cleavage of ICAM-1 in vascular endothelium: a role in atherosclerosis. Arterioscler Thromb Vasc Biol 2009; 29: 27-32.
30. Nikkari ST, Hoyhtya M, Isola J and Nikkari T. Macrophages contain 92-kd gelatinase (MMP-9) at the site of degenerated internal elastic lamina in temporal arteritis. Am J Pathol 1996; 149: 1427-1433.
31. Wright JW, Masino AJ, Reichert JR, Turner GD, Meighan SE, Meighan PC and Harding JW. Ethanol- induced impairment of spatial memory and brain matrix metalloproteinases. Brain Res 2003; 963: 252-261.
32. Sillanaukee P, Kalela A, Seppa K, Hoyhtya M and Nikkari ST. Matrix metalloproteinase-9 is elevated in serum of alcohol abusers. Eur J Clin Invest 2002; 32: 225-229.
33. Shapira Y, Lam AM, Paez A, Artru AA, Laohaprasit V and Donato T. The influence of acute and chronic alcohol treatment on brain edema, cerebral infarct volume and neurological outcome following experimental head trauma in rats. J Neurosurg Anesthesiol 1997; 9: 118-127.