SIRT6 is required for normal retinal function

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Silberman, Dafne M ^a,b   Ross, Kenneth ^b   Sande, Pablo H ^a   Kubota, Shunsuke ^c   Ramaswamy, Sridhar ^b   Apte, Rajendra S ^c   Mostoslavsky, Raul ^b  

^a CER Medical Institute   (Argentina)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 1; METABOTROPIC RECEPTOR 6; SIRTUIN 6; GLUTAMATE RECEPTOR; HISTONE; MESSENGER RNA; SIRT6 PROTEIN, MOUSE; SIRTUIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HISTONE ACETYLATION; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETINA; RETINA CELL; SYNAPTIC TRANSMISSION; UPREGULATION; VISUAL SYSTEM FUNCTION; ACETYLATION; ANIMAL; CLUSTER ANALYSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ACETYLATION; ANIMALS; CLUSTER ANALYSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE TRANSPORTER TYPE 1; HISTONES; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; RECEPTORS, GLUTAMATE; RETINA; RNA, MESSENGER; SIRTUINS;

EID: 84902440245     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098831     Document Type: Article

References (32)

1. Niven JE, Laughlin SB (2008) Energy limitation as a selective pressure on the evolution of sensory systems. J Exp Biol 211: 1792-1804. (Pubitemid 351964926)
2. Graymore CN (1970) Biochemistry of the retina. In: Graymore CN, ed. Biochemistry of the Eye. London: Academic Press. pp 645-735.
3. Winkler BS (1981) Glycolytic and oxidative metabolism in relation to retinal function. J Gen Physiol 77: 667-692.
4. Mantych GS, Hageman GS, Devaskar SU (1993) Characterization of glucose transporter isoforms in the adult and developing human eye. Endocrinology 133: 600-607. (Pubitemid 23238869)
5. Kumagai AK, Glasgow BJ, Pardridge WM (1994) GLUT1 glucose transporter expression in the human diabetic and non-diabetic eye. Invest Ophthalmol Vis Sci 35: 2887-2894. (Pubitemid 24149803)
6. Khan MI, Barlow RB, Weinstock RS (2011) Acute hypoglycemia decreases central retinal function in the human eye. Vis. Res. 51: 1623-26.
7. Skrandies W, Heinrich H (1992) Differential effects of mild hypoglycemia on proximal and distal retinal structures in man as revealed by electroretinography. Neurosci. Lett. 134, 165-8.
8. Umino Y, Everhart D, Solessio E, Cusato K, Pan JC, et al. (2006) Hypoglycemia leads to age-related loss of vision. Proc. Natl. Acad. Sci. U. S. A. 103: 19541-45. (Pubitemid 46026067)
9. McCrimmon RJ, Deary IJ, Huntly BJ, MacLeod KJ, Frier BM (1996) Visual information processing during controlled hypoglycaemia in humans. Brain. 119: 1277-1287. (Pubitemid 26300728)
10. Ewing FM, Deary IJ, McCrimmon RJ, Strachan MW, Frier BM (1998) Effect of acute hypoglycemia on visual information processing in adults with type 1 diabetes mellitus. Physiol Behav 64: .653-660.
11. Barlow RB, Farell B, Khan M. (2003) Metabolic modulation of visual sensitivity. Adv Exp Med Biol 533: 259-267. (Pubitemid 38005287)
12. Jolivet R, Magistretti PJ, Weber B (2009) Deciphering neuron-glia compartmentalization in cortical energy metabolism. Front Neuroenergetics doi:10.3389/neuro.14.004.2009
13. Khatri N, Man HY (2013) Synaptic Activity and Bioenergy Homeostasis: Implications in Brain Trauma and Neurodegenerative Diseases. Front Neurol. 4: 199. eCollection 2013.
14. Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, et al. (1994) Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell 77: 361-9. (Pubitemid 24145197)
15. Dhingra A, Lyubarsky A, Jiang M, Pugh EN Jr, Birnbaumer L, et al. (2000) The light response of ON bipolar neurons requires G[alpha]o. J Neurosci 20: 9053-9058. (Pubitemid 32042907)
16. Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800 (Pubitemid 30111843)
17. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015 (Pubitemid 38393275)
18. Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev., 13: 2570-2580 (Pubitemid 29489648)
19. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, et al. (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124: 315-29. (Pubitemid 43121980)
20. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE et al. (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140: 280-93
21. Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y et al. (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA 100: 10794-10799. (Pubitemid 37140107)
22. Fernandez DC, Pasquini LA, Dorfman D, Aldana Marcos HJ, Rosenstein RE (2012) Ischemic conditioning protects from axoglial alterations of the optic pathway induced by experimental diabetes in rats. PLoSOne. 7(12):e51966. doi: 10.1371/journal.pone.0051966.
23. Hennig AK, Peng G, Chen S (2013) Transcription Coactivators p300 and CBP Are Necessary for Photoreceptor-Specific Chromatin Organization and Gene Expression. PLoS One 10.1371/journal.pone.0069721
24. Izumi Y, Shimamoto K, Benz AM, Hammerman SB, Olney JW, et al. (2002) Glutamate transporters and retinal excitotoxicity. Glia 39: 58-68.
25. Ban N, Ozawa Y, Inaba T, Miyake S, Watanabe M, et al. (2013) Light-dark condition regulates sirtuin mRNA levels in the retina. Exp Gerontol 48: 1212-7.
26. - Howarth C, Gleeson P, Attwell D. (2012) Updated energy budgets for neural computation in the neocortex and cerebellum. J Cereb Blood Flow Metab 32: 1222-32. doi:10.1038/jcbfm.2012.35
27. Dryja TP, McGee TL, Berson EL, Fishman GA, Sandberg MA, et al. (2005) Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. Proc Natl Acad Sci USA 102: 4884-9. (Pubitemid 40471548)
28. Sebastián C, Satterstrom FK, Haigis MC, Mostoslavsky R (2012) From Sirtuin Biology to Human Diseases: An Update. J Biol Chem 287: 42444-52.
29. Zhong Q, Kowluru RA. (2011) Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy. Diabetes 60: 1304-1313.
30. Pelzel HR, Schlamp CL, Waclawski M, Shaw MK, Nickells RW (2012) Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity. Invest Ophthalmol Vis Sci. 53: 1428-1435.
31. Wei L, Liu B, Tuo J, Shen D, Chen P, et al. (2012) Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration. Cell Rep 2: 1151-8
32. Yoo CB, Jones PA (2006) Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5: 37-50.