Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 7, 2014, Pages 1755-1759

  Badia, Roger ^a   Riveira Muñoz, Eva ^a   Clotet, Bonaventura ^a   Esté, José A ^a   Ballana, Ester ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Genome editing; Off target effects; ZFN

Indexed keywords

CHEMOKINE RECEPTOR CCR5; HETERODUPLEX; MESSENGER RNA; ZINC FINGER NUCLEASE; CCR5 PROTEIN, HUMAN; DEOXYRIBONUCLEASE; VIRUS RECEPTOR;

ARTICLE; CELL SURFACE; COMPUTER MODEL; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC CODE; GENETIC RESISTANCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; K562 CELL LINE; VIRAL TROPISM; VIRUS RESISTANCE; VIRUS STRAIN; CELL LINE; ENZYME SPECIFICITY; GENE DELETION; GENE INACTIVATION; GENETICS; METABOLISM; PHYSIOLOGY; PROCEDURES; VIRUS ENTRY;

CELL LINE; DEOXYRIBONUCLEASES; GENE KNOCKOUT TECHNIQUES; HIV-1; HUMANS; RECEPTORS, CCR5; RECEPTORS, HIV; SEQUENCE DELETION; SUBSTRATE SPECIFICITY; VIRUS INTERNALIZATION;

EID: 84902440146     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku072     Document Type: Article

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