Differential interaction of tomosyn with syntaxin and SNAP25 depends on domains in the WD40 β-propeller core and determines its inhibitory activity

Journal of Biological Chemistry

Volumn 289, Issue 24, 2014, Pages 17087-17099

  Bielopolski, Noa ^a   Lam, Alice D ^b   Bar On, Dana ^a   Sauer, Markus ^c   Stuenkel, Edward L ^b   Ashery, Uri ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; STOCHASTIC SYSTEMS;

DELETION MUTANTS; DIFFERENTIAL INTERACTION; INHIBITORY ACTIVITY; OPTICAL RECONSTRUCTION; SMALL CLUSTERS; SNARE PROTEINS; SOLUBLE N-ETHYLMALEIMIDE-SENSITIVE FACTOR ATTACHMENT PROTEIN RECEPTOR; SYNTAXIN;

PROTEINS;

MEMBRANE PROTEIN; PROTEIN WD40; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN; TOMOSYN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA PROPELLER CORE; CELL MEMBRANE; CLUSTER ANALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DELETION MUTANT; DIRECT STOCHASTIC OPTICAL RECONSTRUCTION MICROSCOPY; EMBRYO; EXOCYTOSIS; HUMAN; HUMAN CELL; METABOLIC INHIBITION; MICROSCOPY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RAT;

EXOCYTOSIS; FRAP; MEMBRANE FUSION; MICROSCOPY; NEUROBIOLOGY; SNARE PROTEINS; TOMOSYN;

ANIMALS; BINDING SITES; CELL MEMBRANE; EXOCYTOSIS; GENE DELETION; HEK293 CELLS; HUMANS; MICE; NERVE TISSUE PROTEINS; PC12 CELLS; PROTEIN BINDING; PROTEIN TRANSPORT; R-SNARE PROTEINS; RATS; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; SYNTAXIN 1;

EID: 84902438337     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.515296     Document Type: Article

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