Mechanical and metabolic reflex activation of the sympathetic nervous system in younger adults with metabolic syndrome

Autonomic Neuroscience: Basic and Clinical

Volumn 183, Issue , 2014, Pages 100-105

  Limberg, Jacqueline ^a   Morgan, Barbara ^b   Schrage, William ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Blood pressure; Exercise pressor reflex; MSNA; Obesity; Static exercise

Indexed keywords

ADRENERGIC SYSTEM; ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART RATE; HUMAN; MALE; MECHANOREFLEX ACTIVATION; METABOLIC SYNDROME X; METABOREFLEX ACTIVATION; MUSCLE SYMPATHETIC NERVE ACTIVITY; PRESSOR RESPONSE; PRIORITY JOURNAL; STATIC EXERCISE; SYMPATHETIC TONE; EXERCISE; FOREARM; HAND STRENGTH; ISCHEMIA; MUSCLE CONTRACTION; MUSCLE FATIGUE; PATHOPHYSIOLOGY; PHYSIOLOGY; REFLEX; SKELETAL MUSCLE;

ADULT; BLOOD PRESSURE; EXERCISE; FEMALE; FOREARM; HAND STRENGTH; HEART RATE; HUMANS; ISCHEMIA; MALE; METABOLIC SYNDROME X; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE, SKELETAL; REFLEX;

EID: 84902373698     PISSN: 15660702     EISSN: 18727484     Source Type: Journal    
DOI: 10.1016/j.autneu.2014.03.003     Document Type: Article

References (37)

1. Alam M., Smirk F.H. Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J. Physiol. 1937, 89:372-383.
2. Aldo Ferrara L., Guida L., Ferrara F., De Luca G., Castaldo R., Viola S., Russo R. Blood pressure at rest, during 24h monitoring and in response to sympathetic stimulation in hypertensive patients with metabolic syndrome. Int. J. Cardiol. 2007, 117:312-316.
3. Bassett D.R. Skeletal muscle characteristics: relationships to cardiovascular risk factors. Med. Sci. Sports Exerc. 1994, 26:957-966.
4. Bjorntorp P. Neuroendocrine factors in obesity. J. Endocrinol. 1997, 155:193-195.
5. Coote J.H., Hilton S.M., Perez-Gonzalez J.F. The reflex nature of the pressor response to muscular exercise. J. Physiol. 1971, 215:789-804.
6. Delaney E.P., Greaney J.L., Edwards D.G., Rose W.C., Fadel P.J., Farquhar W.B. Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am. J. Physiol. Heart Circ. Physiol. 2010, 299:H1318-H1327.
7. Dipla K., Zafeiridis A., Koidou I., Geladas N., Vrabas I.S. Altered hemodynamic regulation and reflex control during exercise and recovery in obese boys. Am. J. Physiol. Heart Circ. Physiol. 2010, 299:H2090-H2096.
8. Gaudreault V., Despres J.P., Rheaume C., Almeras N., Bergeron J., Tremblay A., Poirier P. Exercise-induced hypertension in men with metabolic syndrome: anthropometric, metabolic, and hemodynamic features. Metab. Syndr. Relat. Disord. 2013, 11:7-14.
9. Goodwin G.M., McCloskey D.I., Mitchell J.H. Cardiovascular and respiratory responses to changes in central command during isometric exercise at constant muscle tension. J. Physiol. 1972, 226:173-190.
10. Grassi G., Dell'Oro R., Quarti-Trevano F., Scopelliti F., Seravalle G., Paleari F., Gamba P.L., Mancia G. Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 2005, 48:1359-1365.
11. Grundy S.M., Brewer H.B., Cleeman J.I., Smith S.C., Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004, 109:433-438.
12. He D., Bolstad G., Brubakk A., Medbo J.I. Muscle fibre type and dimension in genetically obese and lean Zucker rats. Acta Physiol. Scand. 1995, 155:1-7.
13. Jarvis S.S., VanGundy T.B., Galbreath M.M., Shibata S., Okazaki K., Reelick M.F., Levine B.D., Fu Q. Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 301:R193-R200.
14. Limberg J.K., Morgan B.J., Sebranek J.J., Proctor L.T., Walker B.J., Eldridge M.W., Schrage W.G. Altered neurovascular control of the resting circulation in human metabolic syndrome. J. Physiol. 2012, 590:6109-6119.
15. Mark A.L., Victor R.G., Nerhed C., Wallin B.G. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ. Res. 1985, 57:461-469.
16. Minami M., Atarashi K., Ishiyama A., Hirata Y., Goto A., Omata M. Pressor hyperreactivity to mental and hand-grip stresses in patients with hypercholesterolemia. J. Hypertens. 1999, 17:185-192.
17. Mitchell J.H., Kaufman M.P., Iwamoto G.A. The exercise pressor reflex: its cardiovascular effects, afferent mechanisms, and central pathways. Annu. Rev. Physiol. 1983, 45:229-242.
18. Miyai N., Shiozaki M., Yabu M., Utsumi M., Morioka I., Miyashita K., Arita M. Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors. Hypertens. Res. 2013, 36(6):534-539.
19. Negrao C.E., Trombetta I.C., Batalha L.T., Ribeiro M.M., Rondon M.U., Tinucci T., Forjaz C.L., Barretto A.C., Halpern A., Villares S.M. Muscle metaboreflex control is diminished in normotensive obese women. Am. J. Physiol. Heart Circ. Physiol. 2001, 281:H469-H475.
20. Notarius C.F., Atchison D.J., Floras J.S. Impact of heart failure and exercise capacity on sympathetic response to handgrip exercise. Am. J. Physiol. Heart Circ. Physiol. 2001, 280:H969-H976.
21. Paffenbarger R.S., Blair S.N., Lee I.M., Hyde R.T. Measurement of physical activity to assess health effects in free-living populations. Med. Sci. Sports Exerc. 1993, 25:60-70.
22. Rondon M.U., Laterza M.C., de Matos L.D., Trombetta I.C., Braga A.M., Roveda F., Alves M.J., Krieger E.M., Negrao C.E. Abnormal muscle metaboreflex control of sympathetic activity in never-treated hypertensive subjects. Am. J. Hypertens. 2006, 19:951-957.
23. Rowell L.B. Reflex control of the circulation during exercise. Int. J. Sports Med. 1992, 13(Suppl. 1):S25-S27.
24. Rowell L.B., O'Leary D.S. Reflex control of the circulation during exercise: chemoreflexes and mechanoreflexes. J. Appl. Physiol. 1990, 69:407-418.
25. Rowell L.B., Freund P.R., Hobbs S.F. Cardiovascular responses to muscle ischemia in humans. Circ. Res. 1981, 48:I37-I47.
26. Saito M. Differences in muscle sympathetic nerve response to isometric exercise in different muscle groups. Eur. J. Appl. Physiol. Occup. Physiol. 1995, 70:26-35.
27. Saito M., Mano T., Iwase S. Sympathetic nerve activity related to local fatigue sensation during static contraction. J. Appl. Physiol. 1989, 67:980-984.
28. Sausen M.T., Delaney E.P., Stillabower M.E., Farquhar W.B. Enhanced metaboreflex sensitivity in hypertensive humans. Eur. J. Appl. Physiol. 2009, 105:351-356.
29. Seals D.R. Cardiopulmonary baroreflexes do not modulate exercise-induced sympathoexcitation. J. Appl. Physiol. 1988, 64:2197-2203.
30. Seals D.R. Influence of muscle mass on sympathetic neural activation during isometric exercise. J. Appl. Physiol. 1989, 67:1801-1806.
31. Seals D.R. Influence of active muscle size on sympathetic nerve discharge during isometric contractions in humans. J. Appl. Physiol. 1993, 75:1426-1431.
32. Seals D.R., Enoka R.M. Sympathetic activation is associated with increases in EMG during fatiguing exercise. J. Appl. Physiol. 1989, 66:88-95.
33. Stebbins C.L., Longhurst J.C. Bradykinin-induced chemoreflexes from skeletal muscle: implications for the exercise reflex. J. Appl. Physiol. 1985, 59:56-63.
34. Stebbins C.L., Brown B., Levin D., Longhurst J.C. Reflex effect of skeletal muscle mechanoreceptor stimulation on the cardiovascular system. J. Appl. Physiol. 1988, 65:1539-1547.
35. Trombetta I.C., Batalha L.T., Rondon M.U., Laterza M.C., Kuniyoshi F.H., Gowdak M.M., Barretto A.C., Halpern A., Villares S.M., Negrao C.E. Weight loss improves neurovascular and muscle metaboreflex control in obesity. Am. J. Physiol. Heart Circ. Physiol. 2003, 285:H974-H982.
36. Tsioufis C., Kasiakogias A., Tsiachris D., Kordalis A., Thomopoulos C., Giakoumis M., Bounas P., Pittaras A., Michaelides A., Stefanadis C. Metabolic syndrome and exaggerated blood pressure response to exercise in newly diagnosed hypertensive patients. Eur. J. Prev. Cardiol. 2012, 19:467-473.
37. Vallbo A.B., Hagbarth K.E., Torebjork H.E., Wallin B.G. Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol. Rev. 1979, 59:919-957.