Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 301, Issue 1, 2011, Pages

  Jarvis, Sara S ^a,b   VanGundy, Tiffany B ^a   Melyn Galbreath, M ^a,b   Shibata, Shigeki ^a,b   Okazaki, Kazunobu ^a,b   Reelick, Miriam F ^a   Levine, Benjamin D ^a,b   Fu, Qi ^a,b  

^a PRESBYTERIAN HOSPITAL OF DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cold pressor test; Metaboreflex; Muscle sympathetic nerve activity

Indexed keywords

SEX HORMONE;

ADULT; ARTICLE; BLOOD PRESSURE; COLD PRESSOR TEST; CONTROLLED STUDY; EFFERENT NERVE; FATIGUE; FEMALE; FOLLICULAR PHASE; HAND GRIP; HEART ARREST; HEART RATE; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LUTEAL PHASE; MALE; METABOLIC RATE; MUSCLE MASS; MUSCLE SYMPATHETIC NERVE ACTIVITY; NORMAL HUMAN; POSTEXERCISE CIRCULATORY ARREST; PRIORITY JOURNAL; RESPIRATORY BURST; SEX DIFFERENCE; STATIC EXERCISE; SYMPATHETIC NERVE; SYMPATHETIC REFLEX; VASOCONSTRICTION; VASOMOTOR REFLEX; VASOMOTOR SYMPATHETIC OUTFLOW;

ADULT; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; ESTROGENS; EXERCISE; FATIGUE; FEMALE; HAND STRENGTH; HEART RATE; HUMANS; MALE; MENSTRUAL CYCLE; PROGESTERONE; SYMPATHETIC NERVOUS SYSTEM; VASOMOTOR SYSTEM;

EID: 79959965398     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00562.2010     Document Type: Article

References (39)

1. Armario P, del Rey RH, Martin-Baranera M, Almendros MC, Ceresuela LM, Pardell H. Blood pressure reactivity to mental stress task as a determinant of sustained hypertension after 5 years of follow-up. J Hum Hypertens 17: 181-186, 2003.
2. Carter JR, Lawrence JE, Klein JC. Menstrual cycle alters sympathetic neural responses to orthostatic stress in young, eumenorrheic women. Am J Physiol Endocrinol Metab 297: E85-E91, 2009.
3. Carter JR, Ray CA. Sympathetic neural responses to mental stress: responders, nonresponders and sex differences. Am J Physiol Heart Circ Physiol 296: H847-H853, 2009.
4. Coote JH, Hilton SM, Perez-Gonzalez JF. The reflex nature of the pressor response to muscular exercise. J Physiol 215: 789-804, 1971.
5. Cui J, Wilson TE, Shibasaki M, Hodges NA, Crandall CG. Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans. J Appl Physiol 91: 1679-1686, 2001.
6. Ettinger SM, Silber DH, Collins BG, Gray KS, Sutliff G, Whisler SK, McClain JM, Smith MB, Yang QX, Sinoway LI. Influences of gender on sympathetic nerve responses to static exercise. J Appl Physiol 80: 245-251, 1996.
7. Ettinger SM, Silber DH, Gray KS, Smith MB, Yang QX, Kunselman AR, Sinoway LI. Effects of the ovarian cycle on sympathetic neural outflow during static exercise. J Appl Physiol 85: 2075-2081, 1998.
8. Falkner B, Kushner H, Onesti G, Angelakos ET. Cardiovascular characteristics in adolescents who develop essential hypertension. Hypertension 3: 521-527, 1981.
9. Frey MA, Hoffler GW. Association of sex and age with responses to lower-body negative pressure. J Appl Physiol 65: 1752-1756, 1988.
10. Fu Q, Okazaki K, Shibata S, Shook RP, VanGunday TB, Galbreath MM, Reelick MF, Levine BD. Menstrual cycle effects on sympathetic neural responses to upright tilt. J Physiol 587: 2019-2031, 2009.
11. Fu Q, Witkowski S, Okazaki K, Levine BD. Effects of gender and hypovolemia on sympathetic neural responses to orthostatic stress. Am J Physiol Regul Integr Comp Physiol 289: R109-R116, 2005.
12. Goodwin GM, McCloskey DI, Mitchell JH. Cardiovascular and respiratory responses to changes in central command during isometric exercise at constant muscle tension. J Physiol 226: 173-190, 1972.
13. Halliwill JR. Segregated signal averaging of sympathetic baroreflex responses in humans. J Appl Physiol 88: 767-773, 2000.
14. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach JH, Joyner MJ. Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation. Hypertension 53: 571-576, 2009.
15. Herr MD, Imadojemu V, Kunselman AR, Sinoway LI. Characteristics of the muscle mechanoreflex during quadriceps contractions in humans. J Appl Physiol 86: 767-772, 1999.
16. Ichinose M, Saito M, Wada H, Kitano A, Kondo N, Nishiyasu T. Modulation of arterial baroreflex control of muscle sympathetic nerve activity by muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol 286: H701-H707, 2004.
17. Jarvis SS, Florian JP, Curren MJ, Pawelczyk JA. Sex differences in vasoconstrictor reserve during 70 deg head-up tilt. Exp Physiol 95: 184-193, 2010.
18. Jones PP, Spraul M, Matt KS, Seals DR, Skinner JS, Ravussin E. Gender does not influence sympathetic neural reactivity to stress in healthy humans. Am J Physiol Heart Circ Physiol 270: H350-H357, 1996.
19. Juel C, Honig A, Pilegaard H. Muscle lactate transport studied in sarcolemmal giant vesicles: dependence on fibre type and age. Acta Physiol Scand 143: 361-365, 1991.
20. Kaufman MP, Hayes SG. The exercise pressor reflex. Clin Auton Res 12: 429-439, 2002.
21. Kneale BJ, Chowienczyk PJ, Brett SE, Coltart DJ, Ritter JM. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol 36: 1233-1238, 2000.
22. Lawrence JE, Klein JC, Carter JR. Menstrual cycle elicits divergent forearm vascular responses to vestibular activation in humans. Auton Neurosci 154: 89-93, 2010.
23. Lawrence JE, Ray CA, Carter JR. Vestibulosympathetic reflex during the early follicular and midluteal phases of the menstrual cycle. Am J Physiol Endocrinol Metab 294: E1046-E1050, 2008.
24. Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J 111: 383-390, 1986.
25. Minson CT, Halliwill JR, Young TM, Joyner MJ. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101: 862-868, 2000.
26. Nakamura T, Kawabe K, Sapru HN. Cold pressor test in the rat: medullary and spinal pathways and neurotransmitters. Am J Physiol Heart Circ Physiol 295: H1780-H1787, 2008.
27. Orshal JM, Khalil RA. Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol 286: R233-R249, 2004.
28. Saito M. Differences in muscle sympathetic nerve response to isometric exercise in different muscle groups. Eur J Appl Physiol Occup Physiol 70: 26-35, 1995.
29. Seals DR. Influence of active muscle size on sympathetic nerve discharge during isometric contractions in humans. J Appl Physiol 75: 1426-1431, 1993.
30. Seals DR. Influence of force on muscle and skin sympathetic nerve activity during sustained isometric contractions in humans. J Physiol 462: 147-159, 1993.
31. Seals DR. Sympathetic activation during the cold pressor test: influence of stimulus area. Clin Physiol 10: 123-129, 1990.
32. Simoneau JA, Bouchard C. Human variation in skeletal muscle fibertype proportion and enzyme activities. Am J Physiol Endocrinol Metab 257: E567-E572, 1989.
33. Sinoway LI, Smith MB, Enders B, Leuenberger U, Dzwonczyk T, Gray K, Whisler S, Moore RL. Role of diprotonated phosphate in evoking muscle reflex responses in cats and humans. Am J Physiol Heart Circ Physiol 267: H770-H778, 1994.
34. Sugiyama Y, Matsukawa T, Suzuki H, Iwase S, Shamsuzzaman AS, Mano T. A new method of quantifying human muscle sympathetic nerve activity for frequency domain analysis. Electroencephalogr Clin Neurophysiol 101: 121-128, 1996.
35. Vallbo AB, Hagbarth KE, Torebjork HE, Wallin BG. Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev 59: 919-957, 1979.
36. Victor RG, Bertocci LA, Pryor SL, Nunnally RL. Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. J Clin Invest 82: 1301-1305, 1988.
37. Victor RG, Leimbach WN Jr, Seals DR, Wallin BG, and Mark AL. Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 9: 429-436, 1987.
38. Victor RG, Pryor SL, Secher NH, Mitchell JH. Effects of partial neuromuscular blockade on sympathetic nerve responses to static exercise in humans. Circ Res 65: 468-476, 1989.
39. Villablanca AC, Jayachandran M, Banka C. Atherosclerosis and sex hormones: current concepts. Clin Sci (Lond) 119: 493-513, 2010.