Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: Role of the muscle metaboreflex

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 5, 2010, Pages

  Delaney, Erin P ^a   Greaney, Jody L ^a   Edwards, David G ^a   Rose, William C ^a   Fadel, Paul J ^b   Farquhar, William B ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Blood pressure regulation; Exercise pressor reflex; Hypertension; Muscle sympathetic nerve activity; Static exercise

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; COLD PRESSOR TEST; CONTROLLED STUDY; EXERCISE; FEMALE; HAND GRIP; HUMAN; HYPERTENSION; ISCHEMIA; ISOMETRIC EXERCISE; MALE; MEAN ARTERIAL PRESSURE; MUSCLE CONTRACTION; MUSCLE REFLEX; NERVE CONDUCTION; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SYMPATHETIC NERVE;

AGING; BAROREFLEX; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; CASE-CONTROL STUDIES; EXERCISE; FEMALE; HAND STRENGTH; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MYOCARDIAL ISCHEMIA; RISK FACTORS; SYMPATHETIC NERVOUS SYSTEM;

EID: 78249275575     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00556.2010     Document Type: Article

References (53)

1. Alam M, Smirk FH. Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol 89: 372-383, 1937.
2. Anderson EA, Sinkey CA, Lawton WJ, Mark AL. Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension 14: 177-183, 1989.
3. Aoki K, Sato K, Kondo S, Pyon CB, Yamamoto M. Increased response of blood pressure to rest and handgrip in subjects with essential hypertension. Jpn Circ J 47: 802-809, 1983. (Pubitemid 13025106)
4. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14: 377-381, 1982.
5. Chirinos JA, Segers P, Raina A, Saif H, Swillens A, Gupta AK, Townsend R, Emmi AG Jr, Kirkpatrick JN, Keane MG, Ferrari VA, Wiegers SE, St. John Sutton MG. Arterial pulsatile hemodynamic load induced by isometric exercise strongly predicts left ventricular mass in hypertension. Am J Physiol Heart Circ Physiol 298: H320-H330, 2010.
6. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42: 1206-1252, 2003. (Pubitemid 37553153)
7. Coote JH, Hilton SM, Perez-Gonzalez JF. The reflex nature of the pressor response to muscular exercise. J Physiol 215: 789-804, 1971.
8. Fadel PJ, Ogoh S, Keller DM, Raven PB. Recent insights into carotid baroreflex function in humans using the variable pressure neck chamber. Exp Physiol 88: 671-680, 2003. (Pubitemid 37483897)
9. Farquhar WB, Wenner MM, Delaney EP, Prettyman AV, Stillabower ME. Sympathetic neural responses to increased osmolality in humans. Am J Physiol Heart Circ Physiol 291: H2181-H2186, 2006.
10. Flaa A, Mundal HH, Eide I, Kjeldsen S, Rostrup M. Sympathetic activity and cardiovascular risk factors in young men in the low, normal, and high blood pressure ranges. Hypertension 47: 396-402, 2006. (Pubitemid 43740281)
11. Fu Q, Zhang R, Witkowski S, Arbab-Zadeh A, Prasad A, Okazaki K, Levine BD. Persistent sympathetic activation during chronic antihypertensive therapy: a potential mechanism for long term morbidity? Hypertension 45: 513-521, 2005. (Pubitemid 40411252)
12. Goodwin GM, McCloskey DI, Mitchell JH. Cardiovascular and respiratory responses to changes in central command during isometric exercise at constant muscle tension. J Physiol 226: 173-190, 1972.
13. Grassi G, Cattaneo BM, Seravalle G, Lanfranchi A, Mancia G. Baroreflex control of sympathetic nerve activity in essential and secondary hypertension. Hypertension 31: 68-72, 1998. (Pubitemid 28124694)
14. Hamada M, Kazatani Y, Shigematsu Y, Ito T, Kokubu T, Ishise S. Enhanced blood pressure response to isometric handgrip exercise in patients with essential hypertension: effects of propranolol and prazosin. J Hypertens 5: 305-309, 1987. (Pubitemid 17110037)
15. Hamner JW, Taylor JA. Automated quantification of sympathetic beat-by-beat activity, independent of signal quality. J Appl Physiol 91: 1199-1206, 2001.
16. Hayes SG, McCord JL, Rainier J, Liu Z, Kaufman MP. Role played by acid-sensitive ion channels in evoking the exercise pressor reflex. Am J Physiol Heart Circ Physiol 295: H1720-H1725, 2008.
17. Hoberg E, Schuler G, Kunze B, Obermoser AL, Hauer K, Mautner HP, Schlierf G, Kubler W. Silent myocardial ischemia as a potential link between lack of premonitoring symptoms and increased risk of cardiac arrest during physical stress. Am J Cardiol 65: 583-589, 1990. (Pubitemid 20091883)
18. Ishii M, Sugimoto T, Atarashi K, Igari T, Uehara Y, Doi M, Takagi M, Matsuoka H, Ikeda T, Murao S. Effects of high salt intake on hemodynamic responses to isometric exercise in normotensive subjects and in patients with essential hypertension. Jpn Circ J 47: 1248-1254, 1983. (Pubitemid 14247283)
19. Jones PP, Davy KP, Alexander S, Seals DR. Age-related increase in muscle sympathetic nerve activity is associated with abdominal adiposity. Am J Physiol Endocrinol Metab 272: E976-E980, 1997. (Pubitemid 27293136)
20. Joyner MJ. Baroreceptor function during exercise: resetting the record. Exp Physiol 91: 27-36, 2006.
21. Judy WV, Watanabe AM, Murphy WR, Aprison BS, Yu PL. Sympathetic nerve activity and blood pressure in normotensive backcross rats genetically related to the spontaneously hypertensive rat. Hypertension 1: 598-604, 1979.
22. Kaufman MP, Forster HV. Reflexes controlling circulatory, ventilatory and airway responses to exercise. In: In: Handbook of Physiology Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, p. 381-447.
23. Kaufman MP, Hayes SG. The exercise pressor reflex. Clin Auton Res 12: 429-439, 2002.
24. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH, Mitchell JH. Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J Appl Physiol 55: 105-112, 1983.
25. Kindig AE, Heller TB, Kaufman MP. VR-1 receptor blockade attenuates the pressor response to capsaicin but has no effect on the pressor response to contraction in cats. Am J Physiol Heart Circ Physiol 288: H1867-H1873, 2005.
26. Krogh A, Lindhard J. The regulation of respiration and circulation during the initial stages of muscular work. J Physiol 47: 112-136, 1913.
27. Lambert EA, Schlaich MP. Reduced sympathoneural responses to the cold pressor test in individuals with essential hypertension and in those genetically predisposed to hypertension. No support for the "pressor reactor" hypothesis of hypertension development. Am J Hypertens 17: 863-868, 2004.
28. Laterza MC, de Matos LD, Trombetta IC, Braga AM, Roveda F, Alves MJ, Krieger EM, Negrao CE, Rondon MU. Exercise training restores baroreflex sensitivity in never-treated hypertensive patients. Hypertension 49: 1298-1306, 2007.
29. Leal AK, Williams MA, Garry MG, Mitchell JH, Smith SA. Evidence for functional alterations in the skeletal muscle mechanoreflex and metaboreflex in hypertensive rats. Am J Physiol Heart Circ Physiol 295: H1429-H1438, 2008.
30. Mark AL, Victor RG, Nerhed C, Wallin BG. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57: 461-469, 1985.
31. Markel TA, Daley JC, 3rd Hogeman CS, Herr MD, Khan MH, Gray KS, Kunselman AR, Sinoway LI. Aging and the exercise pressor reflex in humans. Circulation 107: 675-678, 2003.
32. Matsukawa T, Gotoh E, Uneda S, Miyajima E, Shionoiri H, Tochikubo O, Ishii M. Augmented sympathetic nerve activity in response to stressors in young borderline hypertensive men. Acta Physiol Scand 141: 157-165, 1991.
33. McAllister RG Jr. Effect of adrenergic receptor blockade on the responses to isometric handgrip: studies in normal and hypertensive subjects. J Cardiovasc Pharmacol 1: 253-263, 1979.
34. McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol 224: 173-186, 1972.
35. Mitchell JHJB. Wolffe memorial lecture. Neural control of the circulation during exercise. Med Sci Sports Exerc 22: 141-154, 1990.
36. Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE. Triggering of acute myocardial infarction by heavy physical exertion. Protection against triggering by regular exertion Determinants of Myocardial Infarction Onset Study Investigators. N Engl J Med 329: 1677-1683, 1993.
37. Morlin C, Wallin BG, Eriksson BM. Muscle sympathetic activity and plasma noradrenaline in normotensive and hypertensive man. Acta Physiol Scand 119: 117-121, 1983.
38. Murakami E, Matsuzaki K, Sumimoto T, Mukai M, Kazatani Y, Kodama K. Clinical significance of pressor responses to laboratory stressor testing in hypertension. Hypertens Res 19: 133-137, 1996.
39. Ng AV, Callister R, Johnson DG, Seals DR. Sympathetic neural reactivity to stress does not increase with age in healthy humans. Am J Physiol Heart Circ Physiol 267: H344-H353, 1994.
40. Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ. Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45: 142-161, 2005. (Pubitemid 40066429)
41. Raven PB, Fadel PJ, Ogoh S. Arterial baroreflex resetting during exercise: a current perspective. Exp Physiol 91: 37-49, 2006.
42. Rondon MU, Laterza MC, de Matos LD, Trombetta IC, Braga AM, Roveda F, Alves MJ, Krieger EM, Negrao CE. Abnormal muscle metaboreflex control of sympathetic activity in never-treated hypertensive subjects. Am J Hypertens 19: 951-957, 2006.
43. Sausen MT, Delaney EP, Stillabower ME, Farquhar WB. Enhanced metaboreflex sensitivity in hypertensive humans. Eur J Appl Physiol 105: 351-356, 2009.
44. Schobel HP, Heusser K, Schmieder RE, Veelken R, Fischer T, Luft FC. Evidence against elevated sympathetic vasoconstrictor activity in borderline hypertension. J Am Soc Nephrol 9: 1581-1587, 1998.
45. Smith SA, Leal AK, Williams MA, Murphy MN, Mitchell JH, Garry MG. The TRPv1 receptor is a mediator of the exercise pressor reflex in rats. J Physiol 588: 1179-1189, 2010.
46. Smith SA, Williams MA, Leal AK, Mitchell JH, Garry MG. Exercise pressor reflex function is altered in spontaneously hypertensive rats. J Physiol 577: 1009-1020, 2006.
47. Sumimoto T, Hamada M, Muneta S, Shigematsu Y, Fujiwara Y, Sekiya M, Kazatani Y, Hiwada K. Influence of age and severity of hypertension on blood pressure response to isometric handgrip exercise. J Hum Hypertens 5: 399-403, 1991.
48. Sundlof G, Wallin BG. Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age. J Physiol 274: 621-637, 1978. (Pubitemid 8284570)
49. Victor RG, Leimbach WN Jr, Seals DR, Wallin BG, Mark AL. Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 9: 429-436, 1987.
50. Wallin BG, Delius W, Hagbarth KE. Comparison of sympathetic nerve activity in normotensive and hypertensive subjects. Circ Res 33: 9-21, 1973.
51. Wallin BG, Morlin C, Hjemdahl P. Muscle sympathetic activity and venous plasma noradrenaline concentrations during static exercise in normotensive and hypertensive subjects. Acta Physiol Scand 129: 489-497, 1987.
52. Wallin BG, Sundlof G. A quantitative study of muscle nerve sympathetic activity in resting normotensive and hypertensive subjects. Hypertension 1: 67-77, 1979.
53. Whaley editor MH. American College of Sports Medicine Guidelines for Exercise Testing and Prescription. Baltimore, MD: Williams and Wilkins, 2006, p. 106.