Moringa oleifera extracts induce cholangiocarcinoma cell apoptosis by induction of reactive oxygen species production

International Journal of Pharmacognosy and Phytochemical Research

Volumn 6, Issue 2, 2014, Pages 183-189

  Leelawat, S ^a   Leelawat, K ^a,b  

^a RANGSIT UNIVERSITY   (Thailand)

^b RAJAVITHI HOSPITAL   (Thailand)

Author keywords

Apoptosis; Cholangiocarcinoma; Moringa oleifera; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; MORINGA OLEIFERA EXTRACT; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; HUMAN; HUMAN CELL; IC 50; MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PLANT LEAF; PLANT SEED;

EID: 84902367787     PISSN: None     EISSN: 09754873     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Sripa B, Pairojkul C. Cholangiocarcinoma: lessons from Thailand. Current Opinion in Gastroenterololy 2008; 24(3): 349-356.
2. Yang WL, Zhang XC, Zhang DW, Tong BF. Diagnosis and surgical treatment of hepatic hilar cholangiocarcinoma. Hepatobiliary & Pancreatic Diseases International 2007; 6(6): 631-635.
3. Sano T, Shimada K, Sakamoto Y, Yamamoto J, Yamasaki S, Kosuge T. One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality. Annals of Surgery 2006; 244(2): 240-247.
4. Chu D, Adler DG. Malignant biliary tract obstruction: evaluation and therapy. Journal of the National Comprehensive Cancer Network 2010; 8(9): 1033-1044.
5. Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: a food plant with multiple medicinal uses. Phytotherapy Research 2007; 21(1): 17-25.
6. Caceres A, Saravia A, Rizzo S, Zabala L, De Leon E, Nave F. Pharmacologic properties of Moringa oleifera. 2: Screening for antispasmodic, antiinflammatory and diuretic activity. Journal of Ethnopharmacology 1992; 36(3): 233-237.
7. Ndong M, Uehara M, Katsumata S, Sato S, Suzuki K. Preventive effects of Moringa oleifera (Lam) on hyperlipidemia and hepatocyte ultrastructural changes in iron deficient rats. Bioscience, Biotechnology and Biochemistry 2007; 71(8): 1826-1833.
8. Sreelatha S, Jeyachitra A, Padma PR. Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. Food and Chemical Toxicology 2011; 49(6): 1270-1275.
9. Rattanasinganchan P, Leelawat K, Treepongkaruna SA, Tocharoentanaphol C, Subwongcharoen S, Suthiphongchai T, Tohtong R. Establishment and characterization of a cholangiocarcinoma cell line (RMCCA-1) from a Thai patient. World Journal of Gastroenterology 2006; 12(40): 6500-6506.
10. B. Sripa, S. Leungwattanawanit, T. Nitta, Wongkham C, Bhudhisawasdi V, Puapairoj A, Sripa C, Miwa M. Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100). World Journal of Gastroenterology 2005; 11(22): 3392-3397.
11. Lyle PA, Mitsopoulos P, Suntres ZE. Nacetylcysteine modulates the cytotoxic effects of Paclitaxel. Chemotherapy 2011; 57(4): 298-304.
12. Leelawat K, Udomchaiprasertkul W, Narong S, Leelawat S. Induction of MKP-1 prevents the cytotoxic effects of PI3K inhibition in hilar cholangiocarcinoma cells. Journal of Cancer Research and Clinical Oncology 2010; 136(10): 1537-1544.
13. Tepsiri N, Chaturat L, Sripa B, Namwat W, Wongkham S, Bhudhisawasdi V, Tassaneeyakul W. Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World Journal of Gastroenterology 2005; 11(18): 2748-2753.
14. Lv L, Zheng L, Dong D, Xu L, Yin L, Xu Y, Qi Y, Han X, Peng J. Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme. Food and Chemical Toxicology 2013; 59: 657-669.
15. Rasul A, Di J, Millimouno FM, Malhi M, Tsuji I, Ali M, Li J, Li X. Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells. Molecules 2013; 18(8): 9382-9396.
16. Bose CK. Possible role of Moringa oleifera Lam. root in epithelial ovarian cancer. Medscape General Medicine 2007; 9(1): 26.
17. Kalkunte S, Swamy N, Dizon DS, Brard L. Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro. Journal of Experimental Therapeutics and Oncology 2006; 5(4): 287-300.
18. Wu CL, Huang AC, Yang JS, Liao CL, Lu HF, Chou ST, Ma CY, Hsia TC, Ko YC, Chung JG. Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells. Journal of Orthopaedic Research 2011; 29(8): 1199-1209.
19. Xiao D, Powolny AA, Singh SV. Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. The Journal of Biological Chemistry 2008; 283(44): 30151-30163.
20. Shen SC, Yang LY, Lin HY, Wu CY, Su TH, Chen YC. Reactive oxygen species-dependent HSP90 protein cleavage participates in arsenical As(+3)-and MMA(+3)-induced apoptosis through inhibition of telomerase activity via JNK activation. Toxicology and Applied Pharmacology 2008; 229(2): 239-251.