Possible role of Moringa oleifera Lam. Root in epithelial ovarian cancer

MedGenMed Medscape General Medicine

Volumn 9, Issue 1, 2007, Pages

  Bose, Chinmoy K ^a,b,c  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b Kolkata Municipal Corporation   (India)

^c MEDICAL COLLEGE AND HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4' ACETYL ALPHA RHAMNOPYRANOSYLOXY) BENZYL ISOTHIOCYANATE; 4 (RHAMNOPYRANOSYLOXY) BENZYL ISOTHIOCYANATE; ABORTIVE AGENT; BILIRUBIN; CHOLESTEROL; FOLLITROPIN; FOLLITROPIN RECEPTOR; GLUCOSINOLATE; GONADOTROPIN; ISOTHIOCYANIC ACID DERIVATIVE; LUTEINIZING HORMONE; MORINGA OLEIFERA EXTRACT; NERVE GROWTH FACTOR; NIAZIMICIN; PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; BARK; BLOOD CLOTTING DISORDER; BRADYCARDIA; CANCER CELL CULTURE; CANCER INCIDENCE; CANCER INHIBITION; CONTRACEPTION; DRUG ACTIVITY; DRUG STRUCTURE; FEMALE; HORMONE SYNTHESIS; HYPOTENSION; INDIA; INOTROPISM; LIVER TOXICITY; MEDICAL RESEARCH; MENOPAUSE; MENSTRUAL CYCLE; MORINGA OLEIFERA; NEPHROTOXICITY; NERVE PARALYSIS; NONHUMAN; NOTE; OVARY CANCER; PLANT ROOT; RECEPTOR DOWN REGULATION; TRADITIONAL MEDICINE; UTERUS CONTRACTION; CHEMISTRY; HUMAN; METABOLISM; METHODOLOGY; NEOPLASM; OVARY TUMOR; PHYTOTHERAPY; REVIEW;

FEMALE; HUMANS; MORINGA OLEIFERA; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS;

EID: 33846888313     PISSN: 15310132     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (26)

1. Biskind MS, Biskind GS. Development of tumours in the rat ovary after transplantation into the spleen. Proc Soc Exp Biol Med. 1944;55:176-179.
2. Choi JH, Choi KC, Auersperg N, Leung PC. Gonadotropins upregulate the epidermal growth factor receptor through activation of mitogen-activated protein kinases and phosphatidyl-inositol-3-kinase in human ovarian surface epithelial cells. Endocr Relat Cancer. 2005;12:407-421.
3. Zheng W, Magid MS, Kramer EE, Chen YT. Follicle-stimulating hormone receptor is expressed in human ovarian surface epithelium and fallopian tube. Am J Pathol. 1996;148:47-53.
4. Costa-Lotufo LV, Khan MT, Ather A, et al. Studies of the anticancer potential of plants used in Bangladeshi folk medicine. J Ethnopharmacol. 2005;99:21-30.
5. Lampronti I, Khan MT, Bianchi N, et al. Bangladeshi medicinal plant extracts inhibiting molecular interactions between nuclear factors and target DNA sequences mimicking NF-kappaB binding sites. Med Chem. 2005;1:327-333.
6. Kalkunte S, Swamy N, Dizon DS, Brard L. Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro. J Exp Ther Oncol. 2006;5:287-300.
7. Satyan KS, Swamy N, Dizon DS, Singh R, Granai CO, Brard L. Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation. Gynecol Oncol. 2006;103:261-270.
8. Fahey JW. Moringa oleifera: a review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees for Life Journal. 2005;1:5.
9. Rajangam J, Azahakia R, Manavalan S, Thangaraj T, Vijayakumar A, Muthukrishan N. Status of production and utilisation of Moringa in Southern India. In: The Miracle Tree/ The Multiple Attributes of Moringa. Dakar: CWS; 2001: 45-47.
10. Guevara AP, Vargas C, Sakurai H, et al. An antitumor promoter from Moringa oleifera Lam. Mutat Res. 1999;440:181-188.
11. Hsu R, Midcap S, Arbainsyah M, de Witte L. Moringa oleifera: medicinal and socio-economic uses. International Course on Economic Botany, National Herbarium Leiden, The Netherlands; September 2006.
12. Murakami A, Kitazono Y, Jiwajinda S, Koshimizu K, Ohigashi H. Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation. Planta Med. 1998;64:319-323.
13. Bharali R, Tabassum J, Azad MR. Chemomodulatory effect of Moringa oleifera, Lam, on hepatic carcinogen metabolising enzymes, antioxidant parameters and skin papillomagenesis in mice. Asian Pac J Cancer Prev. 2003;4:131-139.
14. Shukla S, Mathur R, Prakash AO. Antifertility profile of the aqueous extract of Moringa oleifera roots. J Ethnopharmacol. 1988;22:51-62.
15. Shukla S, Mathur R, Prakash AO. Biochemical and physiological alterations in female reproductive organs of cyclic rats treated with aqueous extract of Moringa oleifera Lam. Acta Eur Fertil. 1988;19:225-232.
16. Nath D, Sethi N, Singh RK, Jain AK. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J Ethnopharmacol. 1992;36:147-154.
17. Bose CK. Role of nerve growth factor, follicle stimulating hormone receptor and epithelial ovarian cancer. RBM Online. 2005;11:194-197.
18. Ray K, Hazrai R, Guha D. Central inhibitory effect of Moringa oleifera root extract: possible role of neurotransmitters. Indian J Exp Biol. 2003;41:1279-1284.
19. Ray K, Hazra R, Debnath PK, Guha D. Role of 5-hydroxytryptamine in Moringa oleifera induced potentiation of pentobarbitone hypnosis in albino rats. Indian J Exp Biol. 2004;42:632-635.
20. Selman A, Yazigi R, Moyano L, Weinstein-Oppenheimer C, Lara HE, Romero C. Nerve growth factor and its high-affinity receptor trkA participate in the control of vascular endothelial growth factor expression in epithelial ovarian cancer. Gynecol Oncol. 2007; in press.
21. Faizi S, Siddiqui BS, Saleem R, Siddiqui S, Aftab K, Gilani AH. Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure. J Nat Prod. 1994;57:1256-1261.
22. Bhattacharya J, Guha G, Bhattacharya B. Powder microscopy of bark - poison used for abortion: moringa pterygosperma, gaertn. J Indian Forensic Sci. 1978;17:47-50.
23. Mazumder UK, Gupta M, Chakrabarti S, Pal D. Evaluation of hematological and hepatorenal functions of methanolic extract of Moringa oleifera Lam. root treated mice. Indian J Exp Biol. 1999;37:612-614.
24. Woodard D, Stuart R. The Vermont Safe Information Resources, Inc. Material Safety Data Sheet collection. Available at: http://hazard.com/ msds/tox/f/q77/q479.html. Accessed January 27, 2007.
25. Morton JF. The Horseradish Tree, Moringa Pterygosperma (Moringaceae) - a boon to arid lands? Economic Botany. 1991;45:318-333.
26. Choi J-H, Choi K-C, Auersperg N, Leung PCK. Overexpression of follicle-stimulating hormone receptor activates oncogenic pathways in preneoplastic ovarian surface epithelial cells. J Clin Endocrinol Metab. 2004;89:5508-5516.