Percutaneous absorption and distribution of organophosphates (chlorpyrifos and dichlorvos) following dermal exposure and decontamination scenarios using in vitro human skin model

Toxicology Letters

Volumn 229, Issue 1, 2014, Pages 66-72

  Moore, C A ^a   Wilkinson, S C ^a   Blain, P G ^a   Dunn, M ^a   Aust, G A ^a   Williams, F M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Dermal absorption; Exposure; Organophosphates

Indexed keywords

CHLORPYRIFOS; DICHLORVOS; ORGANOPHOSPHATE;

ARTICLE; ENVIRONMENTAL EXPOSURE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MASS SPECTROMETRY; PRIORITY JOURNAL; SCINTILLATION COUNTING; SKIN ABSORPTION; SKIN SURFACE; STRATUM CORNEUM; WASTE MANAGEMENT;

DERMAL ABSORPTION; EXPOSURE; ORGANOPHOSPHATES;

2-PROPANOL; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; DECONTAMINATION; DICHLORVOS; DIFFUSION CHAMBERS, CULTURE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INSECTICIDES; ISOTOPE LABELING; MYRISTATES; PHARMACEUTICAL VEHICLES; PROPYLENE GLYCOL; SKIN ABSORPTION; SOLVENTS; TISSUE DISTRIBUTION;

EID: 84902348678     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.06.008     Document Type: Article

References (20)

1. Bach M., Lippold B.C. Percutaneous penetration enhancement and its quantification. Eur. J. Pharm. Biopharm. 1998, 46:1-13.
2. Barry B.W. Action of skin penetration enhancers - the lipid protein partitioning theory. Int. J. Cosmet. Sci. 1988, 10:281-293.
3. Barry B.W. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur. J. Pharm. Sci. 2001, 14:101-114.
4. Booth E.D., et al. Review of the in vitro and in vivo genotoxicity of dichlorvos. Regul. Toxicol. Pharmacol. 2007, 49:316-326.
5. Brain K.R., et al. Percutaneous penetration of diethanolamine through human skin in vitro: application from cosmetic vehicles. Food Chem. Toxicol. 2005, 43:681-690.
6. Dalton C.H., et al. Absorption of the nerve agent VX (0-ethyl-S-[2(di-isopropylamino) ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro. Toxicol. In Vitro 2006, 20:1532-1536.
7. Dennerlein K., et al. Studies on percutaneous penetration of chemicals - impact of storage conditions for excised human skin. Toxicol. In Vitro 2013, 27:708-713.
8. Duracher L., et al. The influence of alcohol, propylene glycol and 1,2-pentanediol on the permeability of hydrophilic model drug through excised pig skin. Int. J. Pharm. 2009, 374:39-45.
9. FAO/WHO Pesticide residues in food-1999 evaluations. Part II - Toxicological. Joint FAO/WHO meeting on pesticide residues 2000.
10. Farahat F.M., et al. Chlorpyrifos exposures in Egyptian cotton field workers. Neurotoxicology 2010, 10.1016/j.neuro.2010.02.005.
11. Griffin P., et al. Oral and dermal absorption of chlorpyrifos: a human volunteer study. Occup. Environ. Med. 1999, 56:10-13.
12. Griffin P., et al. The in vitro percutaneous penetration of chlorpyrifos. Hum. Exp. Toxicol. 2000, 19:104-107.
13. Luty S., et al. Toxicity of dermally absorbed dichlorvos in rats. Ann. Agric. Environ. Med. 1998, 5:57-64.
14. Meuling W.J.A., et al. Dermal absorption of chlorpyrifos in human volunteers. Int. Arch. Occup. Environ. Health 2005, 78:44-50.
15. OECD Test no. 428: skin absorption: in vitro method. OECD Guidelines for the Testing of Chemicals, Section 4 2004, OECD Publishing. 10.1787/9789264071087-en.
16. Riviere J.E., et al. Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard. J. Appl. Toxicol. 2001, 21:91-99.
17. Tungul A., et al. Micronuclei induction by dichlorvos in the mouse skin. Mutagenesis 1991, 6:405-408.
18. Vallet V., et al. In vitro percutaneous penetration of organophosphorous compounds using full-thickness and split-thickness pig and human skin. Toxicol. In Vitro 2007, 21:1182-1190.
19. van de Sandt J.J.M., et al. In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: a multi-centre comparison study. Regul. Toxicol. Pharmacol. 2004, 39:271-281.
20. Williams A.C., Barry B.W. Penetration enhancers. Adv. Drug Deliv. Rev. 2004, 56:603-618.