Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics

Virchows Archiv

Volumn 464, Issue 6, 2014, Pages 663-672

  Rau, Tilman T ^a,b   Agaimy, Abbas ^a,b   Gehoff, Anastasia ^c   Geppert, Carol ^a,b   Jung, Klaus ^d   Knobloch, Katharina ^a,b   Langner, Cord ^e   Lugli, Alessandro ^f   Groenbus Lurkin, Irene ^g   Nagtegaal, Iris D ^h   Rüschoff, Josef ^c   Saegert, Xavier ⁱ   Sarbia, Mario ^j   Schneider Stock, Regine ^a,b   Vieth, Michael ^b,k   Zwarthoff, Ellen C ^g   Hartmann, Arndt ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Friedrich Alexander University Erlangen Nuremberg   (Germany)

^c Institute of Pathology Nordhessen   (Germany)

^d UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f UNIVERSITY OF BERN   (Switzerland)

^g ERASMUS MEDICAL CENTER   (Netherlands)

^h RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁱ UNIVERSITY OF LEUVEN   (Belgium)

^j Pathology Laboratory München Nord   (Germany)

^k INSTITUTE OF PATHOLOGY   (Germany)

more..

Author keywords

BRAF; Colorectal polyps; Inter observer study; KRAS; Serrated polyps; SSA; TSA

Indexed keywords

ADULT; ARTICLE; BRAF GENE; CANCER RISK; COLORECTAL CANCER; COLORECTAL POLYP; COLORECTAL SERRATED POLYP; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DNA METHYLATION; DYSPLASIA; FEMALE; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERPLASIA; INTERRATER RELIABILITY; MAJOR CLINICAL STUDY; MALE; MLH1 GENE; MULTIPLEX POLYMERASE CHAIN REACTION; MUTATIONAL ANALYSIS; ONCOGENE; ONCOGENE K RAS; PIK3CA GENE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROMOTER REGION; PYROSEQUENCING; RECTUM ADENOMA; SENSITIVITY AND SPECIFICITY; TUMOR CLASSIFICATION; TUMOR LOCALIZATION; TUMOR VOLUME;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOMATOUS POLYPS; COLONIC POLYPS; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MEDICAL ONCOLOGY; NUCLEAR PROTEINS; OBSERVER VARIATION; PHOSPHATIDYLINOSITOL 3-KINASES; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS;

EID: 84902345900     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-014-1569-7     Document Type: Article

References (45)

1. Aust DE, Baretton GB (2010) Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps) - proposal for diagnostic criteria. Virchows Arch 457:291-297. doi:10.1007/s00428-010-0945-1
2. Bariol C, Hawkins NJ, Turner JJ, Meagher AP, Williams DB, Ward RL (2003) Histopathological and clinical evaluation of serrated adenomas of the colon and rectum. Mod Pathol 16:417-423. doi:10.1097/01.MP.0000068236.47471.DB (Pubitemid 36618461)
3. Brenner H, Chang-Claude J, Seiler CM, Hoffmeister M (2012) Interval cancers after negative colonoscopy: population-based case-control study. Gut 61:1576-1582. doi:10.1136/gutjnl-2011-301531
4. Bustamante-Balen M, Bernet L, Cano R, Morell L, Lopez A (2009) Assessing the reproducibility of the microscopic diagnosis of sessile serrated adenoma of the colon. Rev Esp Enferm Dig 101:258-264
5. Carr NJ, Mahajan H, Tan KL, Hawkins NJ, Ward RL (2009) Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma. J Clin Pathol 62:516-518. doi:10.1136/jcp.2008.061960
6. Chan TL, Zhao W, Leung SY, Yuen ST (2003) BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res 63:4878-4881 (Pubitemid 37022620)
7. Coco DP, Goldblum JR, Hornick JL, Lauwers GY, Montgomery E, Srivastava A, Wang H, Odze RD (2011) Inter-observer variability in the diagnosis of crypt dysplasia in Barrett oesophagus. Am J Surg Pathol 35:45-54. doi:10.1097/PAS. 0b013e3181ffdd1400000478-201101000-00005
8. De Sousa EMF, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LP, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJ, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L (2013) Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med 19:614-618. doi:10.1038/nm.3174nm.3174
9. Dhir M, Yachida S, Van Neste L, Glockner SC, Jeschke J, Pappou EP, Montgomery EA, Herman JG, Baylin SB, Iacobuzio-Donahue C, Ahuja N (2011) Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. Int J Cancer 129:1889-1898. doi:10.1002/ijc.25847
10. Ensari A, Bilezikci B, Carneiro F, Dogusoy GB, Driessen A, Dursun A, Flejou JF, Geboes K, de Hertogh G, Jouret-Mourin A, Langner C, Nagtegaal ID, Offerhaus J, Orlowska J, Ristimaki A, Sanz-Ortega J, Savas B, Sotiropoulou M, Villanacci V, Kursun N, Bosman F (2012) Serrated polyps of the colon: how reproducible is their classification? Virchows Arch 461:495-504. doi:10.1007/s00428-012-1319-7
11. Farris AB, Misdraji J, Srivastava A, Muzikansky A, Deshpande V, Lauwers GY, Mino-Kenudson M (2008) Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps. Am J Surg Pathol 32:30-35. doi:10.1097/PAS.0b013e318093e40a00000478-200801000-00005
12. Freeman HJ (2008) Heterogeneity of colorectal adenomas, the serrated adenoma, and implications for screening and surveillance. World J Gastroenterol 14:3461-3463
13. Glatz K, Pritt B, Glatz D, Hartmann A, O'Brien MJ, Blaszyk H (2007) A multinational, internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps. Am J Clin Pathol 127:938-945. doi:10.1309/NXDB6FMTE9X5CD6Y
14. Goldstein NS (2006) Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am J Clin Pathol 125:132-145
15. Gunia S, Berg T, Gradhand E, Becker S (2011) Knowledge of the anatomical polyp location might bias the pathological classification of histologically equivocal colorectal serrated polyps - a consensus study performed by pathology trainees. Pathol Res Pract 207:116-120. doi:10.1016/j.prp.2010.11.007S0344- 0338(10)00271-2
16. Higuchi T, Jass JR (2004) My approach to serrated polyps of the colorectum. J Clin Pathol 57:682-686. doi:10.1136/jcp.2003.01523057/7/682 (Pubitemid 38901479)
17. Higuchi T, Sugihara K, Jass JR (2005) Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 47:32-40. doi:10.1111/j.1365-2559.2005.02180.x (Pubitemid 40978811)
18. Hiraoka S, Kato J, Fujiki S, Kaji E, Morikawa T, Murakami T, Nawa T, Kuriyama M, Uraoka T, Ohara N, Yamamoto K (2010) The presence of large serrated polyps increases risk for colorectal cancer. Gastroenterology 139:1503-1510. doi:10.1053/j.gastro.2010.07.011, 1510 e1501-1503
19. Huang CS, Farraye FA, Yang S, O'Brien MJ (2011) The clinical significance of serrated polyps. Am J Gastroenterol 106:229-240. doi:10.1038/ajg.2010. 429ajg2010429, quiz 241
20. Jass JR (2001) Serrated route to colorectal cancer: back street or super highway? J Pathol 193:283-285. doi:10.1002/1096-9896(200103) 193:3〈283::AID-PATH799〉3.0.CO;2-9
21. Jass JR (2007) Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 50:113-130. doi:10.1111/j.1365-2559.2006.02549.x
22. Jass JR, Baker K, Zlobec I, Higuchi T, Barker M, Buchanan D, Young J (2006) Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer. Histopathology 49:121-131. doi:10.1111/j.1365-2559.2006.02466.x (Pubitemid 44079695)
23. Jass JR, Whitehall VL, Young J, Leggett BA (2002) Emerging concepts in colorectal neoplasia. Gastroenterology 123:862-876 (Pubitemid 34977092)
24. Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Barker MA, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass JR, Leggett BA (2004) BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53:1137-1144. doi:10.1136/gut.2003. 03767153/8/1137 (Pubitemid 38961968)
25. Khalid O, Radaideh S, Cummings OW, O'Brien MJ, Goldblum JR, Rex DK (2009) Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001. World J Gastroenterol 15:3767-3770
26. Lash RH, Genta RM, Schuler CM(2010) Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients. J Clin Pathol 63:681-686. doi:10.1136/jcp.2010.075507
27. Lazarus R, Junttila OE, Karttunen TJ, Makinen MJ (2005) The risk of metachronous neoplasia in patients with serrated adenoma. Am J Clin Pathol 123:349-359. doi:10.1309/VBAG-V3BR-96N2-EQTR
28. Lu FI, van de Niekerk W, Owen D, Tha SP, Turbin DA, Webber DL (2010) Longitudinal outcome study of sessile serrated adenomas of the colorectum: an increased risk for subsequent right-sided colorectal carcinoma. Am J Surg Pathol 34:927-934. doi:10.1097/PAS.0b013e3181e4f256
29. Lurkin I, Stoehr R, Hurst CD, van Tilborg AA, Knowles MA, Hartmann A, Zwarthoff EC (2010) Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes. PLoS One 5:e8802. doi:10.1371/journal.pone.0008802
30. Mesteri I, Bayer G, Meyer J, Capper D, Schoppmann SF, von Deimling A, Birner P (2013) Improved molecular classification of serrated lesions of the colon by immunohistochemical detection of BRAF V600E. Mod Pathol. doi:10.1038/modpathol.2013.126
31. O'Brien MJ, Yang S, Clebanoff JL, Mulcahy E, Farraye FA, Amorosino M, Swan N (2004) Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am J Surg Pathol 28:423-434 (Pubitemid 38436515)
32. Owens SR, Chiosea SI, Kuan SF (2008) Selective expression of gastric mucin MUC6 in colonic sessile serrated adenoma but not in hyperplastic polyp aids in morphological diagnosis of serrated polyps. Mod Pathol 21:660-669. doi:10.1038/modpathol.2008.55 (Pubitemid 351744844)
33. Patil DT, Shadrach BL, Rybicki LA, Leach BH, Pai RK (2012) Proximal colon cancers and the serrated pathway: a systematic analysis of precursor histology and BRAF mutation status. Mod Pathol 25:1423-1431. doi:10.1038/modpathol.2012.98
34. Rex DK, Ahnen DJ, Baron JA, Batts KP, Burke CA, Burt RW, Goldblum JR, Guillem JG, Kahi CJ, Kalady MF, O'Brien MJ, Odze RD, Ogino S, Parry S, Snover DC, Torlakovic EE, Wise PE, Young J, Church J (2012) Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol 107:1315-1329. doi:10.1038/ajg.2012.161, quiz 1314, 1330
35. Sandmeier D, Seelentag W, Bouzourene H (2007) Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice? Virchows Arch 450:613-618. doi:10.1007/s00428-007-0413-8 (Pubitemid 46986228)
36. Sheridan TB, Fenton H, Lewin MR, Burkart AL, Iacobuzio-Donahue CA, Frankel WL, Montgomery E (2006) Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act". Am J Clin Pathol 126:564-571. doi:10.1309/C7JE8BVL8420V5VT (Pubitemid 44498506)
37. Snover DC, Ahnen DJ, Burt RW, Odze RD (2010) Serrated polyps of the colon and rectum and serrated polyposis. In: Bosman F, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumours of the digestive system, 4th edn. IARC, Lyon, pp 160-165
38. Spring KJ, Zhao ZZ, Karamatic R, Walsh MD, Whitehall VL, Pike T, Simms LA, Young J, James M, Montgomery GW, Appleyard M, Hewett D, Togashi K, Jass JR, Leggett BA (2006) High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology 131:1400-1407. doi:10.1053/j.gastro.2006.08.038 (Pubitemid 44708940)
39. Teriaky A, Driman DK, Chande N (2012) Outcomes of a 5-year follow-up of patients with sessile serrated adenomas. Scand J Gastroenterol 47:178-183. doi:10.3109/00365521.2011.645499
40. Torlakovic EE, Gomez JD, Driman DK, Parfitt JR, Wang C, Benerjee T, Snover DC (2008) Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol 32:21-29. doi:10.1097/PAS.0b013e318157f00200000478- 200801000-00004
41. Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, Seruca R (2008) BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis? BMC Cancer 8:255. doi:10.1186/1471-2407-8-255
42. Venables WN, Ripley BD (2002) Modern applied statistics with S. Springer, New York
43. Wong NA, Hunt LP, Novelli MR, Shepherd NA, Warren BF (2009) Observer agreement in the diagnosis of serrated polyps of the large bowel. Histopathology 55:63-66. doi:10.1111/j.1365-2559.2009.03329.x
44. Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R, Liao X, Waldron L, Hoshida Y, Huttenhower C, Chan AT, Giovannucci E, Fuchs C, Ogino S (2012) Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 61:847 - 854. doi:10.1136/gutjnl-2011-300865gutjnl-2011-300865
45. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ (2004) BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol 28:1452-1459 (Pubitemid 39425511)