Alcohol promotes mammary tumor growth through activation of VEGF-dependent tumor angiogenesis

Oncology Letters

Volumn 8, Issue 2, 2014, Pages 673-678

  Lu, Yanmin ^a,b   Ni, Fang ^a   Xu, Mei ^c   Yang, Jinlian ^a   Chen, Ji ^a   Chen, Zhuo ^a   Wang, Xinyi ^a   Luo, Jia ^c   Wang, Siying ^a,c  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b BINZHOU MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alcohol; Angiogenesis; Breast cancer; Endothelial cells

Indexed keywords

ALCOHOL; SEMAXANIB; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST TUMOR; CANCER INHIBITION; CAPILLARY DENSITY; CARCINOGENESIS; COCULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL;

EID: 84902317506     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2146     Document Type: Article

References (31)

1. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
2. Breast Cancer Facts & Figures 2009-2010. American Cancer Society, Atlanta, pp1-36, 2009.
3. Salehi F, Turner MC, Phillips KP, Wigle DT, Krewskia D and Aronson KJ: Review of the etiology of breast cancer with special attention to organochlorines as potential endocrine disruptors. J Toxicol Environ Health B Crit Review 11: 276-300, 2008.
4. Singletary KW and Gapstur SM: Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA 286: 2143-2151, 2001.
5. Seitz HK and Becker P: Alcohol metabolism and cancer risk. Alcohol Res Health 30: 38-41, 44-47, 2007.
6. Seitz HK and Maurer B: The relationship between alcohol metabolism, estrogen levels, and breast cancer risk. Alcohol Res Health 30: 42-43, 2007.
7. Key J, Hodgson S, Omar RZ, et al: Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues. Cancer Causes Control 17: 759-770, 2006.
8. Tjønneland A, Christensen J, Olsen A, et al: Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control 18: 361-373, 2007.
9. Visvanathan K, Crum RM, Strickland PT, et al: Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer. Alcohol Clin Exp Res 31: 467-476, 2007.
10. Weiss HA, Brinton LA, Brogan D, et al: Epidemiology of in situ and invasive breast cancer in women aged under 45. Br J Cancer 73: 1298-1305, 1996.
11. Vaeth PA and Satariano WA: Alcohol consumption and breast cancer stage at diagnosis. Alcohol Clin Exp Res 22: 928-934, 1998.
12. Stoll BA: Alcohol intake and late-stage promotion of breast cancer. Eur J Cancer 35: 1653-1658, 1999.
13. Delli Carpini J, Karam AK and Montgomery L: Vascular endothelial growth factor and its relationship to the prognosis and treatment of breast, ovarian, and cervical cancer. Angiogenesis 13: 43-58, 2010.
14. Amini A, Masoumi Moghaddam S, Morris DL and Pourgholami MH: Review: Utility of vascular endothelial growth factor inhibitors in the treatment of ovarian cancer: from concept to application. J Oncol 2012: 540791, 2011.
15. Yoshiji H, Gomez D, Shibuya M and Thorgeirsson UP: Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res 56: 2013-2016, 1996.
16. Wang S, Xu M, Li F, et al: Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1. Breast Cancer Res Treat 133: 1037-1048, 2012.
17. Ewens A, Luo L, Berleth E, et al: Doxorubicin plus interleukin-2 chemoimmunotherapy against breast cancer in mice. Cancer Res 66: 5419-5426, 2006.
18. Li WL, Fraser JL, Yu SP, Zhu J, Jiang YJ and Wei L: The role of VEGF/VEGFR2 signaling in peripheral stimulation-induced cerebral neurovascular regeneration after ischemic stroke in mice. Exp Brain Res 214: 503-513, 2011.
19. Liu Y, Chen G, Ma C, Bower KA, Xu M, Fan Z, Shi X, Ke ZJ and Luo J: Overexpression of glycogen synthase kinase 3beta sensitizes neuronal cells to ethanol toxicity. J Neurosci Res 87: 2793-2802, 2009.
20. Chen Z, Htay A, Dos Santos W, Gillies GT, Fillmore HL, Sholley MM and Broaddus WC: In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells. J Neurooncol 92: 121-128, 2009.
21. Luo J and Miller MW: Differential sensitivity of human neuroblastoma cell lines to ethanol: correlations with their proliferative responses to mitogenic growth factors and expression of growth factor receptors. Alcohol Clin Exp Res 21: 1186-1194, 1997.
22. Xu M, Bower KA, Wang S, Frank JA, Chen G, Ding M, Wang S, Shi X, Ke Z and Luo J: Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2. Mol Cancer 9: 285, 2010.
23. Tan W, Bailey AP, Shparago M, Busby B, Covington J, Johnson JW, Young E and Gu JW: Chronic alcohol consumption stimulates VEGF expression, tumor angiogenesis and progression of melanoma in mice. Cancer Biol Ther 6: 1211-1217, 2007.
24. Hong J, Holcomb VB, Tekle SA, Fan B and Núñez NP: Alcohol consumption promotes mammary tumor growth and insulin sensitivity. Cancer Lett 294: 229-235, 2010.
25. Yirmiya R, Ben-Eliyahu S, Gale RP, Shavit Y, Liebeskind JC and Taylor AN: Ethanol increases tumor progression in rats: possible involvement of natural killer cells. Brain Behav Immun 6: 74-86, 1992.
26. Gu JW, Elam J, Sartin A, Li W, Roach R and Adair TH: Moderate levels of ethanol induce expression of vascular endothelial growth factor and stimulate angiogenesis. Am J Physiol Regul Integr Comp Physiol 281: R365-R372, 2001.
27. Qian Y, Luo J, Leonard SS, Harris GK, Millecchia L, Flynn DC and Shi X: Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis. J Biol Chem 278: 16189-16197, 2003.
28. Greenberg JI and Cheresh DA: VEGF as an inhibitor of tumor vessel maturation: implications for cancer therapy. Exp Opin Biol Ther 9: 1347-1356, 2009.
29. Rahimi N, Dayanir V and Lashkari K: Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. J Biol Chem 275: 16986-16992, 2000.
30. Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, et al: Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 99: 2625-2634, 1997.
31. Marumo T, Schini-Kerth VB and Busse R: Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells. Diabetes 48: 1131-1137, 1999.