Identification of tubular injury microRNA biomarkers in urine: Comparison of next-generation sequencing and qPCR-based profiling platforms

BMC Genomics

Volumn 15, Issue 1, 2014, Pages

  Nassirpour, Rounak ^a   Mathur, Sachin ^a   Gosink, Mark M ^a   Li, Yizheng ^a   Shoieb, Ahmed M ^a   Wood, Joanna ^b   O'Neil, Shawn P ^a   Homer, Bruce L ^a   Whiteley, Laurence O ^a,c  

^a PFIZER INC   (United States)

^b GUY S HOSPITAL   (United Kingdom)

^c Drug Safety Pfizer Research and Development ^*  (United States)

Author keywords

Gentamicin; Kidney injury; miRNA; Next generation sequencing; NGS; qRT PCR; Small RNA; TruSeq; Urine

Indexed keywords

GENTAMICIN; MICRORNA; MICRORNA 100 5P; MICRORNA 130A 3P; MICRORNA 16 5P; MICRORNA 200B 3P; MICRORNA 203 3P; MICRORNA 208A 3P; MICRORNA 21 5P; MICRORNA 223 3P; MICRORNA 29B 3P; MICRORNA 30C 5P; MICRORNA 320B; MICRORNA 34A 5P; MICRORNA 484; MICRORNA 494 3P; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; HISTOPATHOLOGY; INTERMETHOD COMPARISON; KIDNEY TUBULE DAMAGE; MALE; NEXT GENERATION SEQUENCING; NONHUMAN; PREDICTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SENSITIVITY AND SPECIFICITY; URINALYSIS; ACUTE KIDNEY FAILURE; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; HIGH THROUGHPUT SEQUENCING; KIDNEY TUBULE; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TOXICITY; URINE;

ACUTE KIDNEY INJURY; ANIMALS; BIOLOGICAL MARKERS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENTAMICINS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; KIDNEY TUBULES; MALE; MICRORNAS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER;

EID: 84902301134     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-485     Document Type: Article

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