Proton range monitoring with in-beam PET: Monte Carlo activity predictions and comparison with cyclotron data

Physica Medica

Volumn 30, Issue 5, 2014, Pages 559-569

  Kraan, A C ^a,b   Battistoni, G ^c   Belcari, N ^a,b   Camarlinghi, N ^a,b   Cirrone, G A P ^d   Cuttone, G ^d   Ferretti, S ^a,b   Ferrari, A ^e   Pirrone, G ^a,b   Romano, F ^d   Sala, P ^c   Sportelli, G ^a,b   Straub, K ^a,b   Tramontana, A ^d,f   Del Guerra, A ^a,b   Rosso, V ^a,b  

^a UNIVERSITY OF PISA   (Italy)

^b INFN SEZIONE DI PISA   (Italy)

^c INFN SEZIONE DI MILANO   (Italy)

^d INFN LABORATORI NAZIONALI DEL SUD   (Italy)

^e CERN   (Switzerland)

^f UNIVERSITY OF CATANIA   (Italy)

Author keywords

Cyclotron; Hadron therapy; In beam PET; Treatment quality monitoring

Indexed keywords

BORON 8; CARBON 10; CARBON 11; NITROGEN 12; NITROGEN 13; OXYGEN 14; OXYGEN 15; POLY(METHYL METHACRYLATE); PROTON; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CYCLOTRON; DATA ANALYSIS; DATA PROCESSING; MONTE CARLO METHOD; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PROTON RADIATION; QUALITY CONTROL; RADIOACTIVITY; RADIOISOTOPE DECAY; DEVICES; ELECTRON; IMAGE GUIDED RADIOTHERAPY; IMAGE QUALITY; PROTON THERAPY; THERAPEUTIC USE;

BETA PARTICLES; CYCLOTRONS; MONTE CARLO METHOD; PHANTOMS, IMAGING; POLYMETHYL METHACRYLATE; POSITRON-EMISSION TOMOGRAPHY; PROTON THERAPY; RADIOTHERAPY, IMAGE-GUIDED;

EID: 84902294459     PISSN: 11201797     EISSN: 1724191X     Source Type: Journal    
DOI: 10.1016/j.ejmp.2014.04.003     Document Type: Article

References (47)

1. Loeffler J.S., Durante M. Charged particle therapy optimization, challenges and future directions. Nat Rev Clin Oncol 2013, 10:411-424.
2. Knopf A.C., Lomax A. Invivo proton range verification: a review. Phys Med Biol 2013, 58(15):R131-R160.
3. Zhu X., El Fahkri G. Proton therapy verification with PET imaging. Theranostics 2013, 3(10):731-740.
4. Parodi K., Paganetti H., Shih H.A., Michaud S., Loeffler J.S., DeLaney T.F., et al. Patient study of in-vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy. Int J Radiat Oncol Biol Phys 2007, 68:920-934.
5. Knopf A.C., Parodi K., Paganetti H., Bortfeld T., Daartz J., Engelsman M., et al. Accuracy of proton beam range verification using post-treatment positron emission tomography/computed tomography as function of treatment site. Int J Radiat Oncol Biol Phys 2011, 79:297-304.
6. Nishio T., Miyatake A., Inoue K., Gomi-Miyagishi T., Kohno R., Kameoka S., et al. Experimental verification of proton beam monitoring in a human body by use of activity image of positron-emitting nuclei generated by nuclear fragmentation reaction. Radiol Phys Technol 2008, 1(1):44-54.
7. Hsi W.C., Indelicato D.J., Vargas C., Duvvuri S., Li Z., Palta J. Invivo verification of proton beam path by using post-treatment PET/CT imaging. Med Phys 2009, 36(9):4136-4146.
8. Bauer J., Unholtz D., Sommerer F., Kurz C., Haberer T., Herfarth K., et al. Implementation and initial clinical experience of offline PET/CT-based verification of scanned carbon ion treatment. Radiother Oncol 2013, 107:218-226.
9. Zhu X., España S., Daartz J., Liebsch N., Ouyang J., Paganetti H., et al. Monitoring proton radiation therapy with in-room PET imaging. Phys Med Biol 2011, 56(13):4041-4057.
10. Min C.H., Zhu X., Winey B.A., Grogg K., Testa M., El Fakhri G., et al. Clinical application of in-room positron emission tomography for invivo treatment monitoring in proton radiation therapy. Int J Radiat Oncol Biol Phys 2013, 86(1):183-189.
11. Enghardt W., Parodi K., Crespo P., Fiedler F., Pawelke J., Pönisch F. Dose quantification from in-beam positron emission tomography. Radiother Oncol 2004, 73(Suppl.2):S96-S98.
12. Iseki Y., Kanai T., Kanazawa M., Kitagawa A., Mizuno H., Tomitani T., et al. Range verification system using positron emitting beams for heavy-ion radiotherapy. Phys Med Biol 2004, 49(14):3179-3195.
13. Nishio T., Miyatake A., Ogino T., Nakagawa K., Saijo N., Esumi H., et al. The development and clinical use of a beam ON-LINE PET system mounted on a rotating gantry port in proton therapy. Int J Radiat Oncol Biol Phys 2010, 76(1):277-286.
14. Miyatake A., Nishio T., Ogino T., Saijo N., Esumi H., Uesaka M. Measurement and verification of positron emitter nuclei generated at each treatment site by target nuclear fragment reactions in proton therapy. Med Phys 2010, 37(8):4445-4455.
15. Sportelli G., Belcari N., Camarlinghi N., Cirrone G.A., Cuttone G., Ferretti S., et al. First full-beam PET acquisitions in proton therapy with a modular dual-head dedicated system. Phys Med Biol 2014, 59(1):43-60.
16. Enghardt W., Crespo P., Fiedler F., Hinz R., Parodi K., Pawelke J., et al. Charged hadron tumour therapy monitoring by means of PET. Nucl Instrum Methods A 2004, 525:284-288.
17. Crespo P., Shakirin G., Fiedler F., Enghardt W., Wagner A. Direct time-of-flight for quantitative, real-time in-beam PET: a concept and feasibility study. Phys Med Biol 2007, 52:6795-6811.
18. Yamaya T., Yoshida E., Inaniwa T., Sato S., Nakajima Y., Wakizaka H., et al. Development of a small prototype for a proof-of-concept of OpenPET imaging. Phys Med Biol 2011, 56(4):1123-1137.
19. Tashima H., Yamaya T., Yoshida E., Kinouchi S., Watanabe M., Tanaka E. Asingle-ring OpenPET enabling PET imaging during radiotherapy. Phys Med Biol 2012, 57:4705-4718.
20. Parodi K., Bortfeld T., Haberer T. Comparison between in-beam and offline positron emission tomography imaging of proton and carbon ion therapeutic irradiation at synchrotron- and cyclotron-based facilities. Int J Radiat Oncol Biol Phys 2008, 71(3):945-956.
21. Crespo P., Barthel T., Frais-Kolbl H., Griesmayer E., Heidel K., Parodi K., et al. Suppression of random coincidences during in-beam PET measurements at ion beam radiotherapy facilities. IEEE Trans Nucl Sci 2005, 52(4):980-987.
22. Camarlinghi N., Sportelli G., Battistoni G., Belcari N., Cecchetti M., Cirrone G.A.P., et al. An in-beam PET system for monitoring ion-beam therapy: test on phantoms using clinical 62MeV protons. JINST 2014, 9:C04005.
23. Parodi K., Bortfeld T. Afiltering approach based on Gaussian-powerlaw convolutions for local PET verification of proton radiotherapy. Phys Med Biol 2006, 51(8):1991-2009.
24. Attanasi F., Knopf A., Parodi K., Paganetti H., Bortfeld T., Rosso V., et al. Extension and validation of an analytical model for invivo PET verification of proton therapy: a phantom and clinical study. Phys Med Biol 2011, 56(16):5079-5098.
25. Paganetti H. Range uncertainties in proton therapy and the role of Monte Carlo simulations. Phys Med Biol 2012, 57(11):R99-R117.
26. Seravalli E., Robert C., Bauer J., Stichelbaut F., Kurz C., Smeets J., et al. Monte Carlo calculations of positron emitter yields in proton radiotherapy. Phys Med Biol 2012, 57(6):1659-1673.
27. Parodi K., Ferrari A., Sommerer F., Paganetti H. Clinical CT-based calculations of dose and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code. Phys Med Biol 2007, 52(12):3369-3387.
28. Parodi K., Paganetti H., Cascio E., Flanz J.B. PET/CT imaging for treatment verification after proton therapy: a study with plastic phantoms and metallic implants. Med Phys 2002, 34(2):419-435.
29. Sommerer F., Parodi K., Ferrari A., Poljanc K., Enghardt W., Aiginger H. Investigating the accuracy of the FLUKA code for transport of therapeutic ion beams in matter. Phys Med Biol 2006, 51:4385-4398.
30. 12C beams: experiments and FLUKA simulations for homogeneous targets. Phys Med Biol 2009, 54(13):3979-3996.
31. Parodi K., Enghardt W., Haberer T. In-beam PET measurements of β+ radioactivity induced by proton beams. Phys Med Biol 2002, 47:21-36.
32. Bauer J., Unholtz D., Kurz C., Parodi K. An experimental approach to improve the Monte Carlo modelling of offline PET/CT-images of positron emitters by scanned proton beams. Phys Med Biol 2013, 58:5193-5213.
33. Pshenichnov I., Mishustin I., Greiner I. Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4. Phys Med Biol 2006, 51:6099-6112.
34. Pawelke J., Enghardt W., Haberer T., Hasch B.G., Hinz R., Kramer M., et al. In-beam PET imaging for the control of heavy-ion tumour therapy. IEEE Trans Nucl Sci 1997, 2:1099-1103.
35. 2. Med Phys 2003, 30(7):1926-1931.
36. Del Guerra A., Di Domenico G., Mukhopadhayay D. PET dosimetry in proton radiotherapy: a Monte Carlo study. Appl Radiat Isot 1997, 48(10-12):1617-1624.
37. Oelfke U., Lam G.K., Atkins M.S. Proton dose monitoring with PET: quantitative studies in Lucite. Phys Med Biol 1996, 41(1):177-196.
38. Battistoni G., Cerutti F., Fassò A., Ferrari A., Muraro S., Ranft J., et al. The FLUKA code: description and benchmarking. Proceedings of the hadronic shower simulation workshop 2006, Fermilab, 2006, AIP proceedings 896 2007, 31-49.
39. Ferrari A., Sala P.R., Fasso A., Ranft J. FLUKA: a multi-particle transport code, CERN-2005-10 2005, INFN/TC_05/11, SLAC-R-773.
40. Böhlen T.T., et al. The FLUKA code: developments and challenges for high energy and medical applications. International conference on nuclear data for science and technology 2013, in press.
41. Robert C., Dedes G., Battistoni G., Böhlen T.T., Buvat I., Cerutti F., et al. Distributions of secondary particles in proton and carbon-ion therapy: a comparison between GATE/Geant4 and FLUKA Monte Carlo codes. Phys Med Biol 2013, 58(9):2879-2899.
42. Rosso V., Battistoni G., Belcaria N., Camarlinghi N., Ferrari A., Ferretti S., et al. Anew PET prototype for proton therapy: comparison of data and Monte Carlo simulations. JInst 2013, 8:C03021.
43. Attanasi F., Belcari N., Camarda M., Cirrone G.A.P., Cuttone G., Del Guerra A., et al. Preliminary results of an in-beam PET prototype for proton therapy. Nucl Instrum Methods A 2008, 591(1):296-299.
44. Cirrone G.A.P., Cuttone G., Lojacono P.A., Lo Nigro S., Mongelli V., Patti I.V., et al. A62 Mev proton beam for the treatment of ocular melanoma at Laboratori Nazionali del Sud-INFN (Catania). IEEE Nucl Sci Symp Conf Rec 2003, 5:3658-3662.
45. ROOT toolkit. See , version April 2013. http://root.cern.ch/.
46. Jan S., Santin G., Strul D. GATE: a simulation toolkit for PET and SPECT. Phys Med Biol 2004, 49:4543-4561.
47. the status of CNAO. Eur Phys J Plus 2011, 126:78. S. Rossi on behalf of the CNAO collaboration.