Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2

Free Radical Biology and Medicine

Volumn 73, Issue , 2014, Pages 190-200

  Donkó, Ágnes ^a,b   Morand, Stanislas ^a   Korzeniowska, Agnieszka ^a   Boudreau, Howard E ^a   Zana, Melinda ^b   Hunyady, László ^b   Geiszt, Miklós ^b   Leto, Thomas L ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Duox; Free radicals; Hypothyroidism; Mutation; NADPH oxidase

Indexed keywords

COMPLEMENTARY DNA; DUOX1 PROTEIN; DUOX2 PROTEIN; GLYCINE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; VALINE; DUOX1 PROTEIN, HUMAN; DUOX1 PROTEIN, MOUSE; DUOX2 PROTEIN, HUMAN; DUOXA2 PROTEIN, HUMAN; DUOXA2 PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONGENITAL HYPOTHYROIDISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FLOW CYTOMETRY; GENOTYPE; HEK293 CELL LINE; IMMUNODETECTION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MISSENSE MUTATION; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY; SALIVARY GLAND; SALIVARY GLAND DUCT; WESTERN BLOTTING; WILD TYPE; ANIMAL; CELL LINE; GENETIC TRANSFECTION; GENETICS; HUMAN; HYPOTHYROIDISM; KNOCKOUT MOUSE; METABOLISM; PROTEIN TRANSPORT;

ANIMALS; CELL LINE; CELL MEMBRANE; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; HYDROGEN PEROXIDE; HYPOTHYROIDISM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; NADPH OXIDASE; PROTEIN TRANSPORT; SALIVARY GLANDS; TRANSFECTION;

EID: 84902289264     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.05.006     Document Type: Article

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