Metabolic syndrome and longitudinal changes in cognitive function: A systematic review and meta-analysis

Journal of Alzheimer's Disease

Volumn 41, Issue 1, 2014, Pages 151-161

  Siervo, Mario ^a   Harrison, Stephanie L ^a   Jagger, Carol ^a   Robinson, Louise ^b   Stephan, Blossom C M ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Aging; cognition; cohort studies; metabolic syndrome; risk prediction; systematic review

Indexed keywords

AGE; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; CONFIDENCE INTERVAL; CORRELATION ANALYSIS; DEMENTIA; EFFECT SIZE; EMBASE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MEDLINE; META ANALYSIS; METABOLIC SYNDROME X; PRIORITY JOURNAL; REGRESSION ANALYSIS; REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW; AGED; AGING; COGNITION DISORDERS; FEMALE; MALE; METABOLIC DISEASES; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; COGNITION; COGNITION DISORDERS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; METABOLIC DISEASES; MIDDLE AGED; REGRESSION ANALYSIS;

EID: 84902283754     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-132279     Document Type: Review

References (66)

1. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Fernando C (2005) Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute scientific statement: Executive Summary. Crit Pathw Cardiol 4, 198-203.
2. Lassegue B, Griendling KK (2010) NADPH oxidases: Functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol 30, 653-661.
3. Azumi H, Inoue N, Ohashi Y, Terashima M, Mori T, Fujita H, Awano K, Kobayashi K, Maeda K, Hata K, Shinke T, Kobayashi S, Hirata K, Kawashima S, Itabe H, Hayashi Y, Imajoh-Ohmi S, Itoh H, Yokoyama M (2002) Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris: Important role of NAD (P) H oxidase. Arterioscler Thromb Vasc Biol 22, 1838-1844.
4. Folli F, Corradi D, Fanti P, Davalli A, Paez A, Giaccari A, Perego C, Muscogiuri G (2011) The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro-and macrovascular complications: Avenues for a mechanistic-based therapeutic approach. Curr Diabetes Rev 7, 313-324.
5. Chrissobolis S, Faraci FM (2008) The role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Mol Med 14, 495-502.
6. Meshkani R, Adeli K (2009) Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin Biochem 42, 1331-1346.
7. Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 23, 469-480.
8. Ford ES (2005) Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: A summary of the evidence. Diabetes Care 28, 1769-1778.
9. Chen HJ, Bai CH, Yeh WT, Chiu HC, Pan WH (2006) Influence of metabolic syndrome and general obesity on the risk of ischemic stroke. Stroke 37, 1060-1064.
10. Solfrizzi V, Scafato E, Capurso C, D'Introno A, Colacicco AM, Frisardi V, Vendemiale G, Baldereschi M, Crepaldi G, Di Carlo A, Galluzzo L, Gandin C, Inzitari D, Maggi S, Capurso A, Panza F, Italian Longitudinal Study on Ageing Working Group (2010) Metabolic syndrome and the risk of vascular dementia: The Italian Longitudinal Studyon Ageing. J Neurol Neurosurg Psychiatry 81, 433-440.
11. Raffaitin C, Gin H, Empana JP, Helmer C, Berr C, Tzourio C, Portet F, Dartigues JF, Alperovitch A, Barberger-Gateau P (2009) Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: The three-city study. Diabetes Care 32, 169-174.
12. Razay G, Vreugdenhil A, Wilcock G (2007) The metabolic syndrome and Alzheimer disease. Arch Neurol 64, 93-96.
13. Panza F, Frisardi V, Seripa D, Imbimbo BP, Sancarlo D, D'Onofrio G, Addante F, Paris F, Pilotto A, Solfrizzi V (2011) Metabolic syndrome, mild cognitive impairment, and dementia. Curr Alzheimer Res 8, 492-509.
14. Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM (2005) Impaired insulin and insulin- likegrowthfactorexpression andsignaling mechanisms in Alzheimer's disease-is this type 3 diabetes? J Alzheimers Dis 7, 63-80.
15. Vieira JR, Elkind MS, Moon YP, Rundek T, Boden-Albala B, Paik MC, Sacco RL, Wright CB (2011) The metabolic syndrome and cognitive performance: The Northern Manhattan study. Neuroepidemiology 37, 153-159.
16. Schuur M, Henneman P, van Swieten JC, Zillikens MC, de Koning I, Janssens AC, Witteman JC, Aulchenko YS, Frants RR, Oostra BA, van Dijk KW, van Duijn CM (2010) Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study. Eur J Epidemiol 25, 561-568.
17. Muller M, van Raamt F, Visseren FL, Kalmijn S, Geerlings MI, Mali WP, van der Graaf Y (2010) Metabolicsyndrome and cognition in patients with manifest atherosclerotic disease: The SMART study. Neuroepidemiology 34, 83-89.
18. Liu CY, Zhou HD, Xu ZQ, Zhang WW, Li XY, Zhao J (2009) Metabolic syndrome and cognitive impairment amongst elderly people inChinese population: A cross-sectional study. Eur J Neurol 16, 1022-1027.
19. Luo L, Yang M, Hao Q, Yue J, Dong B (2013) Cross-sectional study examining the association between metabolic syndrome and cognitive function among the oldest old. J Am Med Dir Assoc 14, 105-108.
20. van den Berg E, Biessels GJ, de Craen AJ, Gussekloo J, West-endorp RG (2007) The metabolic syndrome is associated with decelerated cognitive decline in the oldest old. Neurology 69, 979-985.
21. Viscogliosi G, Andreozzi P, Chiriac IM, Cipriani E, Servello A, Ettorre E, Marigliano V (2012) Screening cognition in the elderly with metabolic syndrome. Metab Syndr Relat Disord 10, 358-362.
22. Akbaraly TN, Kivimaki M, Shipley MJ, Tabak AG, Jokela M, Virtanen M, Marmot MG, Ferrie JE, Singh-Manoux A (2010) Metabolic syndrome over 10 years and cognitive functioning in late midlife: The Whitehall II study. Diabetes Care 33, 84-89.
23. Yates KF, Sweat V, Yau PL, Turchiano MM, Convit A (2012) Impact of metabolic syndrome on cognition and brain: A selected review of the literature. Arterioscler Thromb Vasc Biol 32, 2060-2067.
24. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ 339, b2700.
25. Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25, 603-605.
26. Katsumata Y, Todoriki H, Higashiuesato Y, Yasura S, Willcox DC, Ohya Y, Willcox BJ, Dodge HH (2012) Metabolic syndrome and cognitive decline among the oldest oldinOkinawa: In search of a mechanism. The KOCOA Project. J Gerontol A Biol Sci Med Sci 67, 126-134.
27. Knopman DS, Mosley TH, Catellier DJ, Coker LH, Atherosclerosis Risk in Communities Study Brain MRIS (2009) Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: The ARIC MRI Study. Alzheimers Dement 5, 207-214.
28. Lee KS, Eom JS, Cheong HK, Oh BH, Hong CH (2010) Effects of head circumference and metabolic syndrome on cognitive decline. Gerontology 56, 32-38.
29. McEvoy LK, Laughlin GA, Barrett-Connor E, Bergstrom J, Kritz-Silverstein D, Der-Martirosian C, von Muhlen D (2012) Metabolic syndrome and 16-year cognitive decline in community-dwelling older adults. Ann Epidemiol 22, 310-317.
30. Watts AS, Loskutova N, Burns JM, Johnson DK (2013) Metabolic syndrome and cognitive decline in early Alzheimer's disease and healthy older adults. J Alzheimers Dis 35, 253-265.
31. Yaffe K, Haan M, Blackwell T, Cherkasova E, Whitmer RA, West N (2007) Metabolic syndrome and cognitive decline in elderly Latinos: Findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc 55, 758-762.
32. Xiong GL, Plassman BL, Helms MJ, Steffens DC (2006) Vascular risk factors and cognitive decline among elderly male twins. Neurology 67, 1586-1591.
33. Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala EL, Haapala I, Nissinen A, Rauramaa R (2007) Metabolic syndrome and cognitive function:A population-based follow-up study in elderly women. Dement Geriatr Cogn Disord 23, 29-34.
34. Raffaitin C, Feart C, Le Goff M, Amieva H, Helmer C, Akbaraly TN, Tzourio C, Gin H, Barberger-Gateau P (2011) Metabolic syndrome and cognitive decline in French elders: The Three-City Study. Neurology 76, 518-525.
35. Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, Newman AB (2004) The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 292, 2237-2242.
36. Ho RC, Niti M, Yap KB, Kua EH, Ng TP (2008) Metabolic syndrome and cognitive decline in chinese older adults: Results from the Singapore longitudinal ageing studies. Am J Geriatr Psychiatry 16, 519-522.
37. Liu CL, Lin MH, Peng LN, Chen L-K, Su CT, Liu LK, Chen LY (2013) Late-life metabolic syndrome prevents cognitive decline among older men aged 75 years and over: One-year prospective cohort study. J Nutr Health Aging 17, 523-526.
38. Borenstein M, Hedges LV, Higgings JPT, Rothstein HR (2009) Introduction to Meta-Analysis, John Wiley & Sons Ltd, Chichester, West Sussex, PO19 8SQ, UK.
39. Lipsey M, Wilson D (2001) Practical Meta-Analysis, SAGE Publications, London.
40. Schmidt C, Kohlmann T (2008) When to use the odds ratio or the relative risk? Int J Public Health 53, 165-167.
41. Ward A, Arrighi HM, Michels S, Cedarbaum JM (2012) Mild cognitive impairment: Disparity of incidence and prevalence estimates. Alzheimers Dement 8, 14-21.
42. Stephan BCM, Matthews FE, McKeith IG, Bond J, Brayne C, the Medical Research Council Cognitive F, Aging S (2007) Early cognitive change in the general population: How do different definitions work? J Am Geriatr Soc 55, 1534-1540.
43. Wimo A, Winblad B, Aguero-Torres H, von Strauss E (2003) The magnitude of dementia occurrence in the world. Alzheimer Dis Assoc Disord 17, 63-67.
44. Lobo A, Launer LJ, Fratiglioni L, Andersen K, Di Carlo A, Breteler MM, Copeland JR, Dartigues JF, Jagger C, Martinez-Lage J, Soininen H, Hofman A (2000) Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic diseases in the elderly research group. Neurology 54, S4-S9.
45. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7, 177-188.
46. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327, 557-560.
47. Elias MF, Beiser A, Wolf PA, Au R, White RF, D'Agostino RB (2000) The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort. Arch Neurol57, 808-813.
48. Tierney MC, Moineddin R, McDowell I (2010) Prediction of all-cause dementia using neuropsychological tests within 10 and 5 years of diagnosis in a community-based sample. J Alzheimers Dis 22, 1231-1240.
49. Tierney MC, Yao C, Kiss A, McDowell I (2005) Neuropsy-chological tests accurately predict incident Alzheimer disease after 5 and 10 years. Neurology 64, 1853-1859.
50. Hao ZL, Wu B, Wang DR, Liu M (2011) Association between metabolic syndrome and cognitive decline: A systematic review of prospective population-based studies. Acta Neu-ropsychiatr 23, 69-74.
51. Crichton GE, Elias MF, Buckley JD, Murphy KJ, Bryan J, Frisardi V (2012) Metabolic syndrome, cognitive performance, and dementia. J Alzheimers Dis 30 (Suppl 2), S77-S87.
52. Panza F, Frisardi V, Capurso C, Imbimbo BP, Vendemiale G, Santamato A, D'Onofrio G, Seripa D, Sancarlo D, Pilotto A, Solfrizzi V (2010) Metabolic syndrome and cognitive impairment: Current epidemiology and possible underlying mechanisms. J Alzheimers Dis 21, 691-724.
53. Segura B, Jurado MA, Freixenet N, Albuin C, Muniesa J, Junque C (2009) Mental slowness and executive dysfunctions in patients with metabolic syndrome. Neurosci Lett 462, 49-53.
54. van den Berg E, Dekker JM, Nijpels G, Kessels RP, Kappelle LJ, de Haan EH, Heine RJ, Stehouwer CD, Biessels GJ (2008) Cognitive functioning in elderly persons with type 2 diabetes and metabolic syndrome: The Hoorn study. Dement Geriatr Cogn Disord 26, 261-269.
55. Cavalieri M, Ropele S, Petrovic K, Pluta-Fuerst A, Homayoon N, Enzinger C, Grazer A, Katschnig P, Schwingenschuh P, Berghold A, Schmidt R (2010) Metabolic syndrome, brain magnetic resonance imaging, and cognition. Diabetes Care 33, 2489-2495.
56. Muller M, Tang MX, Schupf N, Manly JJ, Mayeux R, Luchsinger JA (2007) Metabolic syndrome and dementia risk in a multiethnic elderly cohort. Dement Geriatr Cogn Disord 24, 185-192.
57. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P (2006) Risk of dementia in diabetes mellitus: A systematic review. Lancet Neurol 5, 64-74.
58. Kloppenborg RP, van den Berg E, Kappelle LJ, Biessels GJ (2008) Diabetes and other vascular risk factors for dementia: Which factor matters most? A systematic review. Eur J Pharmacol 585, 97-108.
59. Frisardi V, Solfrizzi V, Seripa D, Capurso C, Santam-ato A, Sancarlo D, Vendemiale G, Pilotto A, Panza F (2010) Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease. Ageing Res Rev 9, 399-417.
60. Panza F, Frisardi V, Capurso C, Imbimbo BP, Vendemiale G, Santamato A, D'Onofrio G, Seripa D, Sancarlo D, Pilotto A, Solfrizzi V (2010) Metabolic syndrome and cognitive impairment: Current epidemiology and possible underlying mechanisms. J Alzheimers Dis 21, 691-724.
61. Barzilay JI, Stein PK (2011) Associationofthe metabolic syndrome with age-related, nonatherosclerotic, chronic medical conditions. Metab Syndr Relat Disord 9, 327-335.
62. Abbatecola AM, Paolisso G, Lamponi M, Bandinelli S, Lau-retani F, Launer L, Ferrucci L (2004) Insulin resistance and executive dysfunction in older persons. J Am Geriatr Soc 52, 1713-1718.
63. Zhong Y, Miao Y, Jia WP, Yan H, Wang BY, Jin J (2012) Hyperinsulinemia, insulin resistance and cognitive decline in older cohort. Biomed Environ Sci 25, 8-14.
64. Bingham EM, Hopkins D, Smith D, Pernet A, Hallett W, Reed L, Marsden PK, Amiel SA (2002) The role of insulin in human brain glucose metabolism: An 18fluoro-deoxyglucose positron emission tomography study. Diabetes 51, 3384-3390.
65. Le Couteur DG, Simpson SJ (2011) Adaptive senectitude: The prolongevity effects of aging. J Gerontol A Biol Sci Med Sci 66, 179-182.
66. Vischer UM, Safar ME, Safar H, Iaria P, Le Dudal K, Henry O, Herrmann FR, Ducimetiere R, Blacher J (2009) Cardiometabolic determinants of mortality in a geriatric population: Is there a "reverse metabolic syndrome"? Diabetes Metab 35, 108-114.