Prognostic impact of M2 macrophages at neural invasion in patients with invasive ductal carcinoma of the pancreas

European Journal of Cancer

Volumn 50, Issue 11, 2014, Pages 1900-1908

  Sugimoto, Motokazu ^a,b   Mitsunaga, Shuichi ^a   Yoshikawa, Kiyoshi ^a   Kato, Yuichiro ^a   Gotohda, Naoto ^a   Takahashi, Shinichiro ^a   Konishi, Masaru ^a   Ikeda, Masafumi ^a   Kojima, Motohiro ^a   Ochiai, Atsushi ^a   Kaneko, Hironori ^b  

^a NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adjuvant chemotherapy; Locoregional recurrence; M2 macrophages; Neural invasion; Overall survival; Pancreatic cancer; Pancreaticoduodenectomy; Peritoneal dissemination

Indexed keywords

ANTIBODY; BIOLOGICAL MARKER; CD204 ANTIBODY; CISPLATIN; FLUOROURACIL; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CALCULATION; CANCER ADJUVANT THERAPY; CANCER PROGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NERVE PLEXUS; NERVE PLEXUS INVASION; OVERALL SURVIVAL; PANCREAS CARCINOMA; PANCREAS INVASIVE DUCTAL CARCINOMA; PANCREATICODUODENECTOMY; PREDICTOR VARIABLE; PRIORITY JOURNAL; TUMOR INVASION;

ADJUVANT CHEMOTHERAPY; LOCOREGIONAL RECURRENCE; M2 MACROPHAGES; NEURAL INVASION; OVERALL SURVIVAL; PANCREATIC CANCER; PANCREATICODUODENECTOMY; PERITONEAL DISSEMINATION;

AGED; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, PANCREATIC DUCTAL; CHEMOTHERAPY, ADJUVANT; ENTERIC NERVOUS SYSTEM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MICE; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; PROGNOSIS; SCAVENGER RECEPTORS, CLASS A; SURVIVAL ANALYSIS;

EID: 84902269793     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.04.010     Document Type: Article

References (38)

1. R. Siegel, E. Ward, and O. Brawley et al. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths CA Cancer J Clin 61 2011 212 236
2. J.M. Hernandez, C.A. Morton, and S. Al-Saadi et al. The natural history of resected pancreatic cancer without adjuvant chemotherapy Am Surg 76 2010 480 485
3. S. Mitsunaga, T. Hasebe, and T. Kinoshita et al. Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact Am J Surg Pathol 31 2007 1636 1644
4. T. Nagakawa, K. Mori, and T. Nakano et al. Perineural invasion of carcinoma of the pancreas and biliary tract Br J Surg 80 1993 619 621
5. A. Nakao, A. Harada, and T. Nonami et al. Clinical significance of carcinoma invasion of the extrapancreatic nerve plexus in pancreatic cancer Pancreas 12 1996 357 361
6. D. Chatterjee, M.H. Katz, and A. Rashid et al. Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma Am J Surg Pathol 36 2012 409 417
7. H. Takahashi, H. Ohigashi, and O. Ishikawa et al. Perineural invasion and lymph node involvement as indicators of surgical outcome and pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy for resectable pancreatic cancer Ann Surg 255 2012 95 102
8. M.A. Tempero, J.P. Arnoletti, and S.W. Behrman et al. National Comprehensive Cancer Networks. Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines J Natl Compr Cancer Networks 10 2012 703 713
9. A. Imoto, S. Mitsunaga, and M. Inagaki et al. Neural invasion induces cachexia via astrocytic activation of neural route in pancreatic cancer Int J Cancer 131 2012 2795 2807
10. S. Takahashi, T. Hasebe, and T. Oda et al. Extra-tumor perineural invasion predicts postoperative development of peritoneal dissemination in pancreatic ductal adenocarcinoma Anticancer Res 21 2001 1407 1412
11. Z. Zhu, H. Friess, and F.F. diMola et al. Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer J Clin Oncol 17 1999 2419 2428
12. S. Mitsunaga, S. Fujii, and G. Ishii et al. Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer Int J Cancer 127 2010 805 819
13. H. Dai, R. Li, and T. Wheeler et al. Enhanced survival in perineural invasion of pancreatic cancer: an in vitro approach Hum Pathol 38 2007 299 307
14. Z. Gil, O. Cavel, and K. Kelly et al. Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves J Natl Cancer Inst 102 2010 107 118
15. O. Cavel, O. Shomron, and A. Shabtay et al. Endoneurial macrophages induce perineural invasion of pancreatic cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor Cancer Res 72 2012 5733 5743
16. K. Spilsbury, M.A. O'Mara, and W.M. Wu et al. Isolation of a novel macrophage-specific gene by differential cDNA analysis Blood 85 1995 1620 1629
17. V.M. Ripoll, K.M. Irvine, and T. Ravasi et al. Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses J Immunol 178 2007 6557 6566
18. A. Mantovani, S. Sozzani, and M. Locati et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes Trends Immunol 23 2002 549 555
19. M. Ryder, R.A. Ghossein, and J.C. Ricarte-Filho et al. Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer Endocr Relat Cancer 15 2008 1069 1074
20. I.F. Lissbrant, P. Stattin, and P. Wikstrom et al. Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival Int J Oncol 17 2000 445 451
21. Y.Y. Ma, X.J. He, and H.J. Wang et al. Interaction of coagulation factors and tumor-associated macrophages mediates migration and invasion of gastric cancer Cancer Sci 102 2011 336 342
22. C. Subimerb, S. Pinlaor, and N. Khuntikeo et al. Tissue invasive macrophage density is correlated with prognosis in cholangiocarcinoma Mol Med Report 3 2010 597 605
23. K. Yoshikawa, S. Mitsunaga, and T. Kinoshita et al. Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head Cancer Sci 103 2012 2012 2020
24. H. Ueno, T. Kosuge, and Y. Matsuyama et al. A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer Br J Cancer 101 2009 908 915
25. Japan Pancreas Society Classification of pancreatic carcinoma 6th ed. 2009 Kanehara Tokyo
26. L.H. Sobin, M.K. Gospodarowicz, and C. Wittekind International union against cancer: TNM classification of malignant tumours 7th ed. 2009 Wiley-Blackwell New York
27. Y. Fujino, Y. Suzuki, and T. Ajiki et al. Predicting factors for survival of patients with unresectable pancreatic cancer: a management guideline Hepatogastroenterology 50 2003 250 253
28. K. Nakachi, J. Furuse, and H. Ishii et al. Prognostic factors in patients with gemcitabine-refractory pancreatic cancer Jpn J Clin Oncol 37 2007 114 120
29. C. Morizane, T. Okusaka, and S. Morita et al. Construction and validation of a prognostic index for patients with metastatic pancreatic adenocarcinoma Pancreas 40 2011 415 421
30. S. Rotshenker Wallerian degeneration: the innate-immune response to traumatic nerve injury J Neuroinflammation 8 2011 109
31. G.O. Ceyhan, F. Bergmann, and M. Kadihasanoglu et al. Pancreatic neuropathy and neuropathic pain-a comprehensive pathomorphological study of 546 cases Gastroenterology 136 2009 177 186
32. J.P. Neoptolemos, D.D. Stocken, and H. Friess et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer N Engl J Med 350 2004 1200 1210
33. H. Oettle, S. Post, and P. Neuhaus et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial JAMA 297 2007 267 277
34. E.M. Dijkgraaf, M. Heusinkveld, and B. Tummers et al. Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting M2 macrophages in the tumor microenvironment Cancer Res 73 2013 2480 2492
35. L. Zitvogel, L. Apetoh, F. Ghiringhelli, and G. Kroemer Immunological aspects of cancer chemotherapy Nat Rev Immunol 8 1 2008 59 73
36. W. Zhang, X.D. Zhu, and H.C. Sun et al. Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects Clin Cancer Res 16 2010 3420 3430
37. R. Pili, M. Häggman, and W.M. Stadler et al. Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer J Clin Oncol 29 2011 4022 4028
38. P. Sinha, C. Okoro, and D. Foell et al. Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells J Immunol 181 2008 4666 4675