Endoneurial macrophages induce perineural invasion of pancreatic cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor

Cancer Research

Volumn 72, Issue 22, 2012, Pages 5733-5743

  Cavel, Oren ^a   Shomron, Olga ^a   Shabtay, Ayelet ^a   Vital, Joseph ^a   Trejo Leider, Leonor ^a   Weizman, Noam ^a   Krelin, Yakov ^a   Fong, Yuman ^b   Wong, Richard J ^b   Amit, Moran ^a,c   Gil, Ziv ^a,c  

^a TEL AVIV UNIVERSITY   (Israel)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN RET;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; CELL INFILTRATION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TIME LAPSE IMAGING; VIDEO MICROSCOPY; WILD TYPE;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; ENZYME ACTIVATION; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASM INVASIVENESS; NERVOUS SYSTEM; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-RET; STROMAL CELLS;

EID: 84869237693     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-0764     Document Type: Article

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