Clinical and molecular characteristics of HNSCC patients with brain metastases: A retrospective study

European Archives of Oto-Rhino-Laryngology

Volumn 271, Issue 6, 2014, Pages 1715-1722

  Bulut, Olcay Cem ^a   Lindel, Katja ^a   Hauswald, Henrik ^a   Brandt, Regine ^a   Klauschen, Frederick ^b   Wolf, Janina ^a   Wolf, Thomas ^a   Plinkert, Peter K ^a   Simon, Christian ^c   Weichert, Wilko ^a   Stenzinger, Albrecht ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Brain; Distant metastasis; HNSCC; HPV; Oropharynx

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN P53; VIRUS DNA;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BRAIN METASTASIS; CANCER PATIENT; CANCER PROGNOSIS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENE MUTATION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; ONCOGENE; OROPHARYNX CANCER; OVERALL SURVIVAL; PAPILLOMAVIRUS INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; BRAIN TUMOR; COHORT ANALYSIS; GENETICS; HEAD AND NECK TUMOR; MIDDLE AGED; OROPHARYNX TUMOR; PATHOLOGY; PROGNOSIS; SECONDARY; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; VIROLOGY;

AGED; BRAIN NEOPLASMS; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; DISEASE-FREE SURVIVAL; DNA, VIRAL; FEMALE; GENES, P53; HEAD AND NECK NEOPLASMS; HUMAN PAPILLOMAVIRUS 16; HUMANS; MALE; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRUS INFECTIONS; PROGNOSIS; RETROSPECTIVE STUDIES;

EID: 84902268407     PISSN: 09374477     EISSN: 14344726     Source Type: Journal    
DOI: 10.1007/s00405-013-2665-z     Document Type: Article

References (24)

1. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74-108 (Pubitemid 40372904)
2. Leemans CR, Braakhuis BJ, Brakenhoff RH (2011) The molecular biology of head and neck cancer. Nat Rev Cancer 11:9-22
3. Marur S, D'Souza G, Westra WH, Forastiere AA (2010) HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 11:781-789
4. Dayyani F, Etzel CJ, Liu M et al (2010) Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol 29:2-15
5. Takes RP, Rinaldo A, Silver CE, Haigentz M Jr, Woolgar JA, Triantafyllou A, Mondin V, Paccagnella D, de Bree R, Shaha AR, Hartl DM, Ferlito A (2012) Distant metastases from head and neck squamous cell carcinoma Part I Basic aspects. Oral Oncol 48:775-779
6. Leon X, Quer M, Orus C, del Prado Venegas M, Lopez M (2000) Distant metastases in head and neck cancer patients who achieved loco-regional control. Head Neck 22:680-686
7. Merino OR, Lindberg RD, Fletcher GH (1977) An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 40:145-151 (Pubitemid 8160515)
8. Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK (2011) The biology of brain metastases - translation to new therapies. Nat Rev Clin Oncol 8:344-356
9. Alexandru D, Bota DA, Linskey ME (2012) Epidemiology of central nervous system metastases. Prog Neurol Surg 25:13-29
10. Steeg PS, Camphausen KA, Smith QR (2011) Brain metastases as preventive and therapeutic targets. Nat Rev Cancer 11:352-363
11. Jenkinson MD, Haylock B, Shenoy A, Husband D, Javadpour M (2011) Management of cerebral metastasis: evidence-based approach for surgery, stereotactic radiosurgery and radiotherapy. Eur J Cancer 47(5):649-655
12. de Bree R, Mehta DM, Snow GB, Quak JJ (2001) Intracranial metastases in patients with squamous cell carcinoma of the head and neck. Otolaryngol Head Neck Surg 124(2):217-221 (Pubitemid 32167814)
13. González-García R, Sastre-Pérez J, Naval-Gías L, Rodríguez-Campo FJ, Díaz-González FJ (2007) Cavernous sinus metastasis from oropharyngeal squamous cell carcinoma. Med Oral Patol Oral Cir Bucal 12:E166-E170
14. Huang SH, Perez-Ordonez B, Liu FF, Waldron J, Ringash J, Irish J, Cummings B, Siu LL, Kim J, Weinreb I, Hope A, Gullane P, Brown D, Shi W, O'Sullivan B (2012) Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 82(1):276-283
15. Hauswald H, Simon C, Hecht S, Debus J, Lindel K (2011) Long-term outcome and patterns of failure in patients with advanced head and neck cancer. Radiat Oncol 6:70
16. Barnes L, Eveson JW, Reichart P, Sidransky D (eds) (2005) Pathology and Genetics of Head and Neck Tumours (IARC WHO Classification of Tumours). The International Agency for Research on Cancer
17. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (eds) (2009) Seventh Edition of the AJCC Cancer Staging Manual
18. Hristozova T, Konschak R, Stromberger C, Fusi A, Liu Z, Weichert W, Stenzinger A, Budach V, Keilholz U, Tinhofer I (2011) The presence of circulating tumor cells (CTCs) correlates with lymph node metastasis in non-resectable squamous cell carcinoma of the head and neck region (SCCHN). Ann Oncol 8:1878-1885
19. Sotlar K, Diemer D, Dethleffs A, Hack Y, Stubner A, Vollmer N, Menton S, Menton M, Dietz K, Wallwiener D, Kandolf R, Bültmann B (2004) Detection and typing of human papillomavirus by e6 nested multiplex PCR. J Clin Microbiol 7:3176-3184 (Pubitemid 38938077)
20. Kotwall C, Sako K, Razack MS, Rao U, Bakamjian V, Shedd DP (1987) Metastatic patterns in squamous cell cancer of the head and neck. Am J Surg 154(4):439-442 (Pubitemid 18024393)
21. Ruzevick J, Olivi A, Westra WH (2013) Metastatic squamous cell carcinoma to the brain: an unrecognized pattern of distant spread in patients with HPV-related head and neck cancer. J Neurooncol 112:449-454
22. Müller S, Khuri FR, Kono SA, Beitler JJ, Shin DM, Saba NF (2012) HPV positive squamous cell carcinoma of the oropharynx. Are we observing an unusual pattern of metastases? Head Neck Pathol 3:336-344
23. Worden FP, Hooton J, Lee J, Eisbruch A, Wolf GT, Prince M, Moyer J, Teknos T, Chepeha DB, Bradford CR (2009) Association of tobacco (T) use with risk of distant metastases (DM), tumor recurrence, and death in patients (pts) with HPV-positive (?) squamous cell cancer of the oropharynx (SCCOP). J Clin Oncol 27:15s
24. Maxwell JH, Kumar B, Feng FY, Worden FP, Lee JS, Eisbruch A, Wolf GT, Prince ME, Moyer JS, Teknos TN, Chepeha DB, McHugh JB, Urba SG, Stoerker J, Walline HM, Kurnit DM, Cordell KG, Davis SJ, Ward PD, Bradford CR, Carey TE (2010) Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res 16(4):1226-1235