HPV Positive Squamous Cell Carcinoma of the Oropharynx. Are we Observing an Unusual Pattern of Metastases?

Head and Neck Pathology

Volumn 6, Issue 3, 2012, Pages 336-344

  Müller, Susan ^a,b   Khuri, Fadlo R ^a,b   Kono, Scott A ^a,b   Beitler, Jonathan J ^a,b   Shin, Dong M ^a,b   Saba, Nabil F ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

HPV; Metastases; Oropharynx

Indexed keywords

AGED; ARTICLE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METASTASIS; MIDDLE AGED; MORTALITY; OROPHARYNX TUMOR; PAPILLOMAVIRUS INFECTION; PATHOLOGY; SQUAMOUS CELL CARCINOMA; VIROLOGY;

AGED; CARCINOMA, SQUAMOUS CELL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM METASTASIS; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRUS INFECTIONS;

EID: 84865573650     PISSN: 1936055X     EISSN: 19360568     Source Type: Journal    
DOI: 10.1007/s12105-012-0355-6     Document Type: Article

References (11)

1. Fakhry C, Westra WH, Li S. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Can Inst. 2008; 100: 261-9.
2. Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol. 2008; 26: 612-9.
3. Sturgis EM, Cinciripini PM. Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers? Cancer. 2007; 110: 1429-35.
4. Lewis JS Jr, Chernock RD, Haughey BH, Yip JH, Zhang Q, El-Mofty SK. p16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status. Am J Surj Pathol. 2010; 34: 1088-96.
5. Ragin CC, Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer. 2007; 121: 1813-20.
6. Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010; 363: 24-35.
7. Fakhry C, Westra WH, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008; 100: 261-9.
8. Lau HY, Brar S, Klimowicz AC, et al. Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy. Head Neck. 2011; 33: 251-6.
9. Nichols AC, Faquin WC, Westra WH, et al. HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009; 140: 228-34.
10. Huang SH P-OB, Liu FF, Waldron J, Ringash J, Irish J, Cummings B, Siu LL, Kim J, Weinreb I, Hope A, Gullane P, Brown D, Shi W, O'Sullivan B. Atypical clinical behavior of p16 confirmed HPV-Related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int J Radiat Oncol Biol Phys. 2012; 82(1): 276-83.
11. Lewis JS, Khan RA, Masand RP, et al. Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma-a prospective cohort and interobserve variability study. Histopathol. 2012; 60: 427-36.