Activation of cold-sensing transient receptor potential melastatin subtype 8 antagonizes vasoconstriction and hypertension through attenuating RhoA/Rho kinase pathway

Hypertension

Volumn 63, Issue 6, 2014, Pages 1354-1363

  Sun, Jing ^a   Yang, Tao ^a   Wang, Peijian ^a   Ma, Shuangtao ^a   Zhu, Zhenyu ^a   Pu, Yunfei ^a   Li, Li ^a   Zhao, Yu ^a   Xiong, Shiqiang ^a   Liu, Daoyan ^a   Zhu, Zhiming ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hypertension; Menthol; Muscle, smooth, vascular; Rho associated kinases; TRPM8 protein, human; Vasoconstriction

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; MENTHOL; PLACEBO; RHO KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENZYME INHIBITION; FEMALE; HUMAN; HYPERTENSION; IN VIVO STUDY; MALE; MESENTERIC ARTERY; MOUSE; NONHUMAN; PREHYPERTENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE; VASCULARIZATION; VASOCONSTRICTION; VASODILATATION; WILD TYPE;

HYPERTENSION; MENTHOL; MUSCLE; RHO-ASSOCIATED KINASES; SMOOTH, VASCULAR; TRPM8 PROTEIN, HUMAN; VASOCONSTRICTION;

ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; CALCIUM; CAPSULES; CELLS, CULTURED; COLD TEMPERATURE; FEMALE; HUMANS; HYPERTENSION; MALE; MENTHOL; MESENTERIC ARTERIES; MICE; MICE, KNOCKOUT; MIDDLE AGED; MUSCLE, SMOOTH; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRPM CATION CHANNELS; VASOCONSTRICTION;

EID: 84902265596     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.113.02573     Document Type: Article

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