Analysis of volatile human urinary metabolome by solid-phase microextraction in combination with gas chromatography-mass spectrometry for biomarker discovery: Application in a pilot study to discriminate patients with renal cell carcinoma

European Journal of Cancer

Volumn 50, Issue 11, 2014, Pages 1993-2002

  Monteiro, Márcia ^a   Carvalho, Márcia ^a,b   Henrique, Rui ^a,c   Jerónimo, Carmen ^a,c   Moreira, Nathalie ^a,d   De Lourdes Bastos, Maria ^a   De Pinho, Paula Guedes ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^c PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^d UNIVERSIDADE CATÓLICA PORTUGUESA   (Portugal)

Author keywords

Central composite design; Gas chromatography ion trap mass spectrometry; Headspace solid phase microextraction; Renal cell carcinoma; Urine; Volatile metabolomic profile

Indexed keywords

BIOLOGICAL MARKER; DIMETICONE; DIVINYLBENZENE; POLYACRYLIC ACID; SODIUM CHLORIDE; VOLATILE ORGANIC COMPOUND;

ADULT; AGED; ARTICLE; CENTRAL COMPOSITE DESIGN; CLINICAL ARTICLE; CONTROLLED STUDY; FACTORIAL DESIGN; FEMALE; HUMAN; HYDROLYSIS; KIDNEY CARCINOMA; MALE; MASS FRAGMENTOGRAPHY; METABOLOME; METABOLOMICS; NOISE REDUCTION; PH; PHYSICAL CHEMISTRY; PILOT STUDY; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SOLID PHASE MICROEXTRACTION; TEMPERATURE; URINALYSIS;

CENTRAL COMPOSITE DESIGN; GAS CHROMATOGRAPHY-ION TRAP/MASS SPECTROMETRY; HEADSPACE SOLID-PHASE MICROEXTRACTION; RENAL CELL CARCINOMA; URINE; VOLATILE METABOLOMIC PROFILE;

ADULT; AGED; CARCINOMA, RENAL CELL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; KIDNEY NEOPLASMS; MALE; METABOLOME; MIDDLE AGED; PILOT PROJECTS; SOLID PHASE MICROEXTRACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84902252993     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.04.011     Document Type: Article

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