Triterpenoid saponins from Stauntonia chinensis ameliorate insulin resistance via the AMP-activated protein kinase and IR/IRS-1/PI3K/Akt pathways in insulin-resistant HepG2 cells

International Journal of Molecular Sciences

Volumn 15, Issue 6, 2014, Pages 10446-10458

  Hu, Xin ^a   Wang, Sha ^a   Xu, Jing ^a   Wang, De Bing ^a   Chen, Yu ^a   Yang, Guang Zhong ^a  

^a SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES   (China)

Author keywords

AMPK; HepG2 cells; Insulin resistance; IR IRS 1 PI3K Akt signaling pathway; Stauntonia chinensis

Indexed keywords

HEXOKINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYRUVATE KINASE; SAPONIN DERIVATIVE; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; SAPONIN; TRITERPENE;

ANTIDIABETIC ACTIVITY; ARTICLE; CELL CULTURE; CELL VIABILITY ASSAY; CONTROLLED STUDY; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MEDICINAL PLANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAUNTONIA CHINENSIS; WESTERN BLOTTING; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HEPG2 CELL LINE; ISOLATION AND PURIFICATION; METABOLISM; PHOSPHORYLATION; STREPTOPHYTA; TOXICITY;

AMP-ACTIVATED PROTEIN KINASES; CELL SURVIVAL; HEP G2 CELLS; HEXOKINASE; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRUVATE KINASE; RECEPTOR, INSULIN; SAPONINS; SIGNAL TRANSDUCTION; STREPTOPHYTA; TRITERPENES;

EID: 84902242869     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms150610446     Document Type: Article

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