-
1
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359:1757-65.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
2
-
-
84856217699
-
Systematic review of pharmacogenetic testing for predicting clinical benefit to anti-EGFR therapy in metastatic colorectal cancer
-
Lin JS, Webber EM, Senger CA, et al. Systematic review of pharmacogenetic testing for predicting clinical benefit to anti-EGFR therapy in metastatic colorectal cancer. Am J Cancer Res 2011;1:650-62.
-
(2011)
Am J Cancer Res
, vol.1
, pp. 650-662
-
-
Lin, J.S.1
Webber, E.M.2
Senger, C.A.3
-
3
-
-
67649652208
-
BRAF mutation in metastatic colorectal cancer
-
Tol J, Nagtegaal ID, Punt CJ. BRAF mutation in metastatic colorectal cancer. N Engl J Med 2009;361:98-9.
-
(2009)
N Engl J Med
, vol.361
, pp. 98-99
-
-
Tol, J.1
Nagtegaal, I.D.2
Punt, C.J.3
-
4
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008;26:5705-12.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
5
-
-
78649473910
-
The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients
-
Farina-Sarasqueta A, Van Lijnschoten G, Moerland E, et al. The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol 2010;21:2396-402.
-
(2010)
Ann Oncol
, vol.21
, pp. 2396-2402
-
-
Farina-Sarasqueta, A.1
Van Lijnschoten, G.2
Moerland, E.3
-
6
-
-
73349094741
-
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
-
Laurent-Puig P, Cayre A, Manceau G, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 2009;27:5924-30.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5924-5930
-
-
Laurent-Puig, P.1
Cayre, A.2
Manceau, G.3
-
7
-
-
79960932729
-
BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: A meta-analysis
-
Mao C, Liao RY, Qiu LX, et al. BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis. Mol Biol Rep 2011;38:2219-23.
-
(2011)
Mol Biol Rep
, vol.38
, pp. 2219-2223
-
-
Mao, C.1
Liao, R.Y.2
Qiu, L.X.3
-
8
-
-
68149165771
-
Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
-
Souglakos J, Philips J, Wang R, et al. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer 2009;101:465-72.
-
(2009)
Br J Cancer
, vol.101
, pp. 465-472
-
-
Souglakos, J.1
Philips, J.2
Wang, R.3
-
9
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009;360:563-72.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
10
-
-
79952282994
-
BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer
-
Yokota T, Ura T, Shibata N, et al. BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer. Br J Cancer 2011;104:856-62.
-
(2011)
Br J Cancer
, vol.104
, pp. 856-862
-
-
Yokota, T.1
Ura, T.2
Shibata, N.3
-
11
-
-
84880022343
-
Predictive and prognostic role of BRAF mutation in patients with metastatic colorectal cancer treated with antiepidermal growth factor receptor monoclonal antibodies: A meta-analysis
-
Xu Q, Xu AT, Zhu MM, et al. Predictive and prognostic role of BRAF mutation in patients with metastatic colorectal cancer treated with antiepidermal growth factor receptor monoclonal antibodies: a meta-analysis. J Dig Dis 2013;14:409-16.
-
(2013)
J Dig Dis
, vol.14
, pp. 409-416
-
-
Xu, Q.1
Xu, A.T.2
Zhu, M.M.3
-
12
-
-
73349114941
-
KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
-
Richman SD, Seymour MT, Chambers P, et al. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol 2009;27:5931-7.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5931-5937
-
-
Richman, S.D.1
Seymour, M.T.2
Chambers, P.3
-
13
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010;11:753-62.
-
(2010)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
-
14
-
-
84870067191
-
Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia
-
Andrulis M, Penzel R, Weichert W, et al. Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia. Am J Surg Pathol 2012;36:1796-800.
-
(2012)
Am J Surg Pathol
, vol.36
, pp. 1796-1800
-
-
Andrulis, M.1
Penzel, R.2
Weichert, W.3
-
15
-
-
84873715417
-
Detection of the BRAF V600E mutation in serous ovarian tumors: A comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allelespecific PCR
-
Bosmuller H, Fischer A, Pham DL, et al. Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allelespecific PCR. Hum Pathol 2013;44:329-35.
-
(2013)
Hum Pathol
, vol.44
, pp. 329-335
-
-
Bosmuller, H.1
Fischer, A.2
Pham, D.L.3
-
16
-
-
79959580390
-
Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
-
Capper D, Preusser M, Habel A, et al. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 2011;122:11-9.
-
(2011)
Acta Neuropathol
, vol.122
, pp. 11-19
-
-
Capper, D.1
Preusser, M.2
Habel, A.3
-
17
-
-
84857030136
-
Immunohistochemical testing of BRAF V600E status in 1, 120 tumor tissue samples of patients with brain metastases
-
Capper D, Berghoff AS, Magerle M, et al. Immunohistochemical testing of BRAF V600E status in 1, 120 tumor tissue samples of patients with brain metastases. Acta Neuropathol 2012;123:223-33.
-
(2012)
Acta Neuropathol
, vol.123
, pp. 223-233
-
-
Capper, D.1
Berghoff, A.S.2
Magerle, M.3
-
18
-
-
84862109270
-
Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma
-
Koperek O, Kornauth C, Capper D, et al. Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma. Am J Surg Pathol 2012;36:844-50.
-
(2012)
Am J Surg Pathol
, vol.36
, pp. 844-850
-
-
Koperek, O.1
Kornauth, C.2
Capper, D.3
-
19
-
-
84871619722
-
Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma
-
Long GV, Wilmott JS, Capper D, et al. Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma. Am J Surg Pathol 2013;37:61-5.
-
(2013)
Am J Surg Pathol
, vol.37
, pp. 61-65
-
-
Long, G.V.1
Wilmott, J.S.2
Capper, D.3
-
20
-
-
84874581453
-
Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in primary lung adenocarcinoma Caucasian patients
-
Ilie M, Long E, Hofman V, et al. Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in primary lung adenocarcinoma Caucasian patients. Ann Oncol 2013;24:742-8.
-
(2013)
Ann Oncol
, vol.24
, pp. 742-748
-
-
Ilie, M.1
Long, E.2
Hofman, V.3
-
21
-
-
76049098292
-
Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases
-
Baldus SE, Schaefer KL, Engers R, et al. Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res 2010;16:790-9.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 790-799
-
-
Baldus, S.E.1
Schaefer, K.L.2
Engers, R.3
-
22
-
-
63949084084
-
Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant
-
Molinari F, Martin V, Saletti P, et al. Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant. Br J Cancer 2009;100:1087-94.
-
(2009)
Br J Cancer
, vol.100
, pp. 1087-1094
-
-
Molinari, F.1
Martin, V.2
Saletti, P.3
-
23
-
-
34347345073
-
Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: Optimising EGFR-targeted treatment options
-
Scartozzi M, Bearzi I, Berardi R, et al. Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: optimising EGFR-targeted treatment options. Br J Cancer 2007;97:92-7.
-
(2007)
Br J Cancer
, vol.97
, pp. 92-97
-
-
Scartozzi, M.1
Bearzi, I.2
Berardi, R.3
-
24
-
-
84888860816
-
Mutation landscape in melanoma patients clinical implications of heterogeneity of BRAF mutations
-
Heinzerling L, Baiter M, Kuhnapfel S, et al. Mutation landscape in melanoma patients clinical implications of heterogeneity of BRAF mutations. Br J Cancer 2013;109:2833-41.
-
(2013)
Br J Cancer
, vol.109
, pp. 2833-2841
-
-
Heinzerling, L.1
Baiter, M.2
Kuhnapfel, S.3
-
25
-
-
84882715124
-
Tumor homogeneity between primary and metastatic sites for BRAF status in metastatic melanoma determined by immunohistochemical and molecular testing
-
Boursault L, Haddad V, Vergier B, et al. Tumor homogeneity between primary and metastatic sites for BRAF status in metastatic melanoma determined by immunohistochemical and molecular testing. PLoS One 2013;8:e70826.
-
(2013)
PLoS One
, vol.8
-
-
Boursault, L.1
Haddad, V.2
Vergier, B.3
-
26
-
-
84890565737
-
Heterogeneity of the EGFR mutation status between the primary tumor and metastatic lymph node and the sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer
-
Shimizu K, Yukawa T, Hirami Y, et al. Heterogeneity of the EGFR mutation status between the primary tumor and metastatic lymph node and the sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer. Target Oncol 2013;8:237-42.
-
(2013)
Target Oncol
, vol.8
, pp. 237-242
-
-
Shimizu, K.1
Yukawa, T.2
Hirami, Y.3
-
27
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012;366:883-92.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
-
28
-
-
84884365015
-
The causes and consequences of genetic heterogeneity in cancer evolution
-
Burrell RA, McGranahan N, Bartek J, et al. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 2013;501:338-45.
-
(2013)
Nature
, vol.501
, pp. 338-345
-
-
Burrell, R.A.1
McGranahan, N.2
Bartek, J.3
-
29
-
-
23844497341
-
Sensitive sequencing method for KRAS mutation detection by Pyrosequencing
-
Ogino S, Kawasaki T, Brahmandam M, et al. Sensitive sequencing method for KRAS mutation detection by Pyrosequencing. J Mol Diagn 2005;7:413-21.
-
(2005)
J Mol Diagn
, vol.7
, pp. 413-421
-
-
Ogino, S.1
Kawasaki, T.2
Brahmandam, M.3
-
30
-
-
84863723714
-
A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens
-
Gonzalez De Castro D, Angulo B, Gomez B, et al. A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens. Br J Cancer 2012;107:345-51.
-
(2012)
Br J Cancer
, vol.107
, pp. 345-351
-
-
Gonzalez De Castro, D.1
Angulo, B.2
Gomez, B.3
-
31
-
-
0041333110
-
BRAF mutations in metastatic melanoma: A possible association with clinical outcome
-
Kumar R, Angelini S, Czene K, et al. BRAF mutations in metastatic melanoma: a possible association with clinical outcome. Clin Cancer Res 2003;9:3362-8.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3362-3368
-
-
Kumar, R.1
Angelini, S.2
Czene, K.3
-
32
-
-
84880265173
-
BRAF V600E-specific immunohistochemistry for the exclusion of Lynch syndrome in MSI-H colorectal cancer
-
Capper D, Voigt A, Bozukova G, et al. BRAF V600E-specific immunohistochemistry for the exclusion of Lynch syndrome in MSI-H colorectal cancer. Int J Cancer 2013;133:1624-30.
-
(2013)
Int J Cancer
, vol.133
, pp. 1624-1630
-
-
Capper, D.1
Voigt, A.2
Bozukova, G.3
-
33
-
-
80053475784
-
KRAS and BRAF mutation analysis in metastatic colorectal cancer: A cost-effectiveness analysis from a Swiss perspective
-
Blank PR, Moch H, Szucs TD, et al. KRAS and BRAF mutation analysis in metastatic colorectal cancer: a cost-effectiveness analysis from a Swiss perspective. Clin Cancer Res 2011;17:6338-46.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6338-6346
-
-
Blank, P.R.1
Moch, H.2
Szucs, T.D.3
-
34
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Kohne CH, Lang I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011;29:2011-9.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2011-2019
-
-
Van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
-
35
-
-
84876674310
-
KRAS and BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue
-
Mostert B, Jiang Y, Sieuwerts AM, et al. KRAS and BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue. Int J Cancer 2013;133:130-41.
-
(2013)
Int J Cancer
, vol.133
, pp. 130-141
-
-
Mostert, B.1
Jiang, Y.2
Sieuwerts, A.M.3
-
36
-
-
84871401779
-
BRAF mutations in colorectal cancer: Clinical relevance and role in targeted therapy
-
Yaeger R, Saltz L. BRAF mutations in colorectal cancer: clinical relevance and role in targeted therapy. J Natl Compr Canc Netw 2012;10:1456-8.
-
(2012)
J Natl Compr Canc Netw
, vol.10
, pp. 1456-1458
-
-
Yaeger, R.1
Saltz, L.2
-
37
-
-
84901272027
-
The potential value of immunohistochemistry as a screening tool for oncogenic targets of personalized lung cancer therapy
-
Ilie M, Hofman P. The potential value of immunohistochemistry as a screening tool for oncogenic targets of personalized lung cancer therapy. J Oncopathol 2013;1:1.
-
(2013)
J Oncopathol
, vol.1
, pp. 1
-
-
Ilie, M.1
Hofman, P.2
-
38
-
-
84880725363
-
Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma
-
Adackapara CA, Sholl LM, Barletta JA, et al. Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma. Histopathology 2013;63:187-93.
-
(2013)
Histopathology
, vol.63
, pp. 187-193
-
-
Adackapara, C.A.1
Sholl, L.M.2
Barletta, J.A.3
-
39
-
-
84884513645
-
BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome
-
Toon CW, Walsh MD, Chou A, et al. BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome. Am J Surg Pathol 2013;37:1592-602.
-
(2013)
Am J Surg Pathol
, vol.37
, pp. 1592-1602
-
-
Toon, C.W.1
Walsh, M.D.2
Chou, A.3
-
40
-
-
84892704695
-
Detection of BRAF p. V600E mutations on melanoma by immunohistochemistry has a good interobserver reproducibility
-
Marin C, Beauchet A, Capper D, et al. Detection of BRAF p. V600E mutations on melanoma by immunohistochemistry has a good interobserver reproducibility. Arch Pathol Lab Med 2014;138:71-5.
-
(2014)
Arch Pathol Lab Med
, vol.138
, pp. 71-75
-
-
Marin, C.1
Beauchet, A.2
Capper, D.3
-
41
-
-
84869220840
-
Utilization of a MAB for BRAF (V600E) detection in papillary thyroid carcinoma
-
Bullock M, O'Neill C, Chou A, et al. Utilization of a MAB for BRAF (V600E) detection in papillary thyroid carcinoma. Endocr Relat Cancer 2012;19:779-84.
-
(2012)
Endocr Relat Cancer
, vol.19
, pp. 779-784
-
-
Bullock, M.1
O'Neill, C.2
Chou, A.3
-
42
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF (V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF (V600E) inhibition through feedback activation of EGFR. Nature 2012;483:100-3.
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
|