IFN- γ -secreting-mesenchymal stem cells exert an antitumor effect in vivo via the trail pathway

Journal of Immunology Research

Volumn 2014, Issue , 2014, Pages

  Yang, Xinyuan ^a   Du, Jingchun ^b   Xu, Xia ^b   Xu, Chun ^b   Song, Wu ^c  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CASPASE 3; GAMMA INTERFERON; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND ANTIBODY; UNCLASSIFIED DRUG; TNFSF10 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW; CONTROLLED STUDY; ENZYME ACTIVATION; IN VITRO STUDY; LUNG CARCINOMA; LUNG TUMOR; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; WESTERN BLOTTING; AGONISTS; ANIMAL; CARCINOMA; CELL ENGINEERING; COCULTURE; CYTOLOGY; DRUG SCREENING; GENE EXPRESSION; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HUMAN; IMMUNOLOGY; LENTIVIRINAE; LUNG NEOPLASMS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; NUDE MOUSE; PATHOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; APOPTOSIS; CARCINOMA; CASPASE 3; CELL ENGINEERING; CELL LINE, TUMOR; COCULTURE TECHNIQUES; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC VECTORS; HUMANS; INTERFERON-GAMMA; LENTIVIRUS; LUNG NEOPLASMS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, NUDE; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSDUCTION, GENETIC; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84902141044     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2014/318098     Document Type: Article

References (27)

1. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells. Science 1999 284 5411 143 147 2-s2.0-0033515827 10.1126/science.284.5411.143 (Pubitemid 29282067)
2. Lee R. H., Kim B., Choi I., Kim H., Choi H. S., Suh K., Bae Y. C., Jung J. S., Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cellular Physiology and Biochemistry 2004 14 4-6 311 324 2-s2.0-4444269045 10.1159/000080341 (Pubitemid 39179200)
3. Klein C., Strobel J., Zingsem J., Ex vivo expansion of hematopoietic stem- and progenitor cells from cord blood in coculture with mesenchymal stroma cells from amnion, chorion, Wharton's jelly, amniotic fluid, cord blood, and bone marrow. Tissue Engineering Part A 2013 19 23-24 2577 2585
4. Le Blanc K., Ringdén O., Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation 2005 11 5 321 334 2-s2.0-17444379357 10.1016/j.bbmt.2005.01.005 (Pubitemid 40542924)
5. Le Blanc K., Rasmusson I., Sundberg B., Götherström C., Hassan M., Uzunel M., Ringdén O., Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004 363 9419 1439 1441 2-s2.0-2342482526 10.1016/S0140-6736(04)16104-7 (Pubitemid 38586721)
6. Kidd S., Spaeth E., Dembinski J. L., Dietrich M., Watson K., Klopp A., Battula V. L., Weil M., Andreeff M., Marini F. C., Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells 2009 27 10 2614 2623 2-s2.0-70350243071 10.1002/stem.187
7. Xu C., Lin L., Cao G., Interferon- secreting mesenchymal stem cells exert potent antitumor effect in vivo. Oncogene 2013 2013, article 458 10.1038/onc.2013.458
8. Gao Y., Yao A., Zhang W., Lu S., Yu Y., Deng L., Yin A., Xia Y., Sun B., Wang X., Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice. Oncogene 2010 29 19 2784 2794 2-s2.0-77952426237 10.1038/onc.2010.38
9. McLean K., Gong Y., Choi Y., Deng N., Yang K., Bai S., Cabrera L., Keller E., McCauley L., Cho K. R., Buckanovich R. J., Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. Journal of Clinical Investigation 2011 121 8 3206 3219 2-s2.0-79961006281 10.1172/JCI45273
10. Lin J. T., Wang J. Y., Chen M. K., Colon cancer mesenchymal stem cells modulate the tumorigenicity of colon cancer through interleukin 6. Experimental Cell Research 2013 319 14 2216 2229
11. Moniri M. R., Sun X.-Y., Rayat J., Dai D., Ao Z., He Z., Verchere C. B., Dai L.-J., Warnock G. L., TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells. Cancer Gene Therapy 2012 19 9 652 658 2-s2.0-84865271049 10.1038/cgt.2012.46
12. Du J., Zhou L., Chen X., Yan S., Ke M., Lu X., Wang Z., Yu W., Xiang A. P., IFN- γ -primed human bone marrow mesenchymal stem cells induce tumor cell apoptosis in vitro via tumor necrosis factor-related apoptosis-inducing ligand. International Journal of Biochemistry and Cell Biology 2012 44 8 1305 1314 2-s2.0-84861471254 10.1016/j.biocel.2012.04.015
13. Ke H., Wang P., Yu W., Liu X., Liu C., Yang F., Mao F. F., Zhang L., Zhang X., Lahn B. T., Xiang A. P., Derivation, characterization and gene modification of cynomolgus monkey mesenchymal stem cells. Differentiation 2009 77 3 256 262 2-s2.0-61449264687 10.1016/j.diff.2008.09.021
14. Grisendi G., Bussolari R., Cafarelli L., Petak I., Rasini V., Veronesi E., De Santis G., Spano C., Tagliazzucchi M., Barti-Juhasz H., Scarabelli L., Bambi F., Frassoldati A., Rossi G., Casali C., Morandi U., Horwitz E. M., Paolucci P., Conte P., Dominici M., Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. Cancer Research 2010 70 9 3718 3729 2-s2.0-77951749301 10.1158/0008-5472.CAN-09-1865
15. Luo J., Ok Lee S., Liang L., Infiltrating bone arrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling. Oncogene 2013 2013, article 233 10.1038/onc.2013.233
16. Kidd S., Spaeth E., Watson K., Burks J., Lu H., Klopp A., Andreeff M., Marini F. C., Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS ONE 2012 7 2 2-s2.0-84857411051 10.1371/journal.pone.0030563 e30563
17. Zhu Y., Sun Z., Han Q., Liao L., Wang J., Bian C., Li J., Yan X., Liu Y., Shao C., Zhao R. C., Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1. Leukemia 2009 23 5 925 933 2-s2.0-67349195445 10.1038/leu.2008.384
18. Sun B., Roh K.-H., Park J.-R., Lee S.-R., Park S.-B., Jung J.-W., Kang S.-K., Lee Y.-S., Kang K.-S., Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model. Cytotherapy 2009 11 3 289 298 2-s2.0-68049124516 10.1080/14653240902807026
19. Waterman R. S., Tomchuck S. L., Henkle S. L., Betancourt A. M., A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype. PLoS ONE 2010 5 4 2-s2.0-77956420421 10.1371/journal.pone.0010088 e10088
20. Waterman R. S., Henkle S. L., Betancourt A. M., Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis. PLoS ONE 2012 7 9 2-s2.0-84866689845 10.1371/journal.pone.0045590 e45590
21. Valente G., Ozmen L., Novelli F., Geuna M., Palestro G., Forni G., Garotta G., Distribution of interferon- γ receptor in human tissues. European Journal of Immunology 1992 22 9 2403 2412 2-s2.0-0026661047
22. Der S. D., Zhou A., Williams B. R. G., Silverman R. H., Identification of genes differentially regulated by interferon β or γ using oligonucleotide arrays. Proceedings of the National Academy of Sciences of the United States of America 1998 95 26 15623 15628 2-s2.0-0032417696 10.1073/pnas.95.26.15623 (Pubitemid 29018750)
23. Jett J. R., Maksymiuk A. W., Su J. Q., Mailliard J. A., Krook J. E., Tschetter L. K., Kardinal C. G., Twito D. I., Levitt R., Gerstner J. B., Knowlton L., Phase III trial of recombinant interferon gamma in complete responders with small-cell lung cancer. Journal of Clinical Oncology 1994 12 11 2321 2326 2-s2.0-0027970573 (Pubitemid 24346702)
24. Schiller J. H., Pugh M., Kirkwood J. M., Karp D., Larson M., Borden E., Eastern cooperative group trial of interferon gamma in metastatic melanoma: an innovative study design. Clinical Cancer Research 1996 2 1 29 36 (Pubitemid 26042175)
25. Kyriakou C. A., Yong K. L., Benjamin R., Pizzey A., Dogan A., Singh N., Davidoff A. M., Nathwani A. C., Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFlk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt's lymphoma in a murine model. Journal of Gene Medicine 2006 8 3 253 264 2-s2.0-33645211749 10.1002/jgm.840
26. Chang L. J., Gay E. E., The molecular genetics of lentiviral vectors-current and future perspectives. Current Gene Therapy 2001 1 3 237 251 2-s2.0-0035453298
27. Loebinger M. R., Eddaoudi A., Davies D., Janes S. M., Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Research 2009 69 10 4134 4142 2-s2.0-66249083525 10.1158/0008-5472.CAN-08-4698