Idiopathic-generalized epilepsy shows profound white matter diffusion-tensor imaging alterations

Human Brain Mapping

Volumn 35, Issue 7, 2014, Pages 3332-3342

  Focke, Niels K ^a,b   Diederich, Christine ^a   Helms, Gunther ^a   Nitsche, Michael A ^a   Lerche, Holger ^b   Paulus, Walter ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Diffusion tensor imaging; Fiber tracking; Idiopathic generalized epilepsy; Juvenile myoclonic epilepsy; MRI

Indexed keywords

ADULT; ARTICLE; BRAIN REGION; CLASSIFICATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CALLOSUM; DIFFUSION TENSOR IMAGING; FEMALE; FRACTIONAL ANISOTROPY; GENERALIZED EPILEPSY; HOSPITAL PATIENT; HUMAN; MALE; PRIORITY JOURNAL; PYRAMIDAL TRACT; STATISTICS; SUPERIOR FRONTAL GYRUS; WHITE MATTER; BRAIN; BRAIN MAPPING; DIFFUSION WEIGHTED IMAGING; MYELINATED NERVE; MYOCLONUS EPILEPSY; PATHOLOGY; THREE DIMENSIONAL IMAGING; YOUNG ADULT;

ADULT; BRAIN; BRAIN MAPPING; DIFFUSION MAGNETIC RESONANCE IMAGING; EPILEPSY, GENERALIZED; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MYOCLONIC EPILEPSY, JUVENILE; NERVE FIBERS, MYELINATED; YOUNG ADULT;

EID: 84902136524     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.22405     Document Type: Article

References (29)

1. Alexander A, Lee J, Lazar M, Field A (2007): Diffusion tensor imaging of the brain. Neurotherapeutics 4:316-329.
2. Behrens TEJ, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CAM, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, Thompson AJ, Brady JM, Matthews PM (2003): Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci 6:750-757.
3. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshe SL, Nordli D, Plouin P, Scheffer IE (2010): Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia 51:676-685.
4. Bernhardt BC, Rozen DA, Worsley KJ, Evans AC, Bernasconi N, Bernasconi A (2009): Thalamo-cortical network pathology in idiopathic generalized epilepsy: Insights from MRI-based morphometric correlation analysis. NeuroImage 46:373-381.
5. Betting LE, Mory SB, Li LM, Lopes-Cendes I, Guerreiro MM, Guerreiro CAM, Cendes F (2006): Voxel-based morphometry in patients with idiopathic generalized epilepsies. NeuroImage 32:498-502.
6. Bonilha L, Edwards JC, Kinsman SL, Morgan PS, Fridriksson J, Rorden C, Rumboldt Z, Roberts DR, Eckert MA, Halford JJ (2010): Extrahippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy. Epilepsia 51:519-528.
7. Chahboune H, Mishra AM, DeSalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X, Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H (2009): DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. NeuroImage 47:459-466.
8. Ciumas C, Savic I (2006): Structural changes in patients with primary generalized tonic and clonic seizures. Neurology 67:683-686.
9. Destrieux C, Fischl B, Dale A, Halgren E (2010): Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature. NeuroImage 53:1-15.
10. Focke NK, Yogarajah M, Bonelli SB, Bartlett PA, Symms MR, Duncan JS (2008): Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. NeuroImage 40:728-737.
11. Helms G, Ciumas C, Kyaga S, Savic I (2006): Increased thalamus levels of glutamate and glutamine (Glx) in patients with idiopathic generalised epilepsy. J Neurol Neurosurg Psychiatr 77:489-494.
12. Huang W, Lu G, Zhang Z, Zhong Y, Wang Z, Yuan C, Jiao Q, Qian Z, Tan Q, Chen G, Liu Y (2011): Gray-matter volume reduction in the thalamus and frontal lobe in epileptic patients with generalized tonic-clonic seizures. J Neuroradiol 38:298-303.
13. Janz D (1985): Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy). Acta Neurol Scand 72:449-459.
14. Jones NC, O'Brien TJ, Powell KL (2011): Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures. Neurosci Lett 497:185-193.
15. Kim JH, Lee JK, Koh SB, Lee SA, Lee JM, Kim SI, Kang JK (2007): Regional grey matter abnormalities in juvenile myoclonic epilepsy: A voxel-based morphometry study. NeuroImage 37:1132-1137.
16. Kwan P, Brodie MJ (2000): Early identification of refractory epilepsy. New Engl J Med 342:314-319.
17. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H (2001): Diffusion tensor imaging: Concepts and applications. J Magn Reson Imag 13:534-546.
18. Liu M, Concha L, Beaulieu C, Gross DW (2011): Distinct white matter abnormalities in different idiopathic generalized epilepsy syndromes. Epilepsia 52:2267-2275.
19. Meencke HJ (1985): Neuron density in the molecular layer of the frontal cortex in primary generalized epilepsy. Epilepsia 26:450-454.
20. Meencke HJ, Janz D (1984): Neuropathological findings in primary generalized epilepsy: A study of eight cases. Epilepsia 25:8-21.
21. O'Muircheartaigh J, Vollmar C, Barker GJ, Kumari V, Symms MR, Thompson P, Duncan JS, Koepp MJ, Richardson MP (2011): Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy. Neurology 76:34-40.
22. Savic I, Lekvall A, Greitz D, Helms G (2000): MR spectroscopy shows reduced frontal lobe concentrations of N-acetyl aspartate in patients with juvenile myoclonic epilepsy. Epilepsia 41:290-296.
23. Schoene-Bake J-C, Faber J, Trautner P, Kaaden S, Tittgemeyer M, Elger CE, Weber B (2009): Widespread affections of large fiber tracts in postoperative temporal lobe epilepsy. NeuroImage 46:569-576.
24. Smith SM, Johansen-Berg H, Jenkinson M, Rueckert D, Nichols TE, Miller KL, Robson MD, Jones DK, Klein JC, Bartsch AJ, Behrens TE (2007): Acquisition and voxelwise analysis of multi-subject diffusion data with tract-based spatial statistics. Nat Protoc 2:499-503.
25. Song SK, Yoshino J, Le TQ, Lin SJ, Sun SW, Cross AH, Armstrong RC (2005): Demyelination increases radial diffusivity in corpus callosum of mouse brain. NeuroImage 26:132-140.
26. Vulliemoz S, Vollmar C, Koepp MJ, Yogarajah M, O'Muircheartaigh J, Carmichael DW, Stretton J, Richardson MP, Symms MR, Duncan JS (2011): Connectivity of the supplementary motor area in juvenile myoclonic epilepsy and frontal lobe epilepsy. Epilepsia 52:507-514.
27. Wheeler-Kingshott CAM, Cercignani M (2009): About "axial" and "radial" diffusivities. Magn Reson Med 61:1255-1260.
28. Woermann FG, Free SL, Koepp MJ, Sisodiya SM, Duncan JS (1999): Abnormal cerebral structure in juvenile myoclonic epilepsy demonstrated with voxel-based analysis of MRI. Brain: J Neurol 122 (Pt 11):2101-2108.
29. Yogarajah M, Focke NK, Bonelli SB, Thompson P, Vollmar C, McEvoy AW, Alexander DC, Symms MR, Koepp MJ, Duncan JS (2010): The structural plasticity of white matter networks following anterior temporal lobe resection. Brain: J Neurol 133:2348-2364.