Negative association of serum IL-6 and IL-17 with type-II diabetes retinopathy

Iranian Journal of Immunology

Volumn 11, Issue 1, 2014, Pages 40-48

  Afzal, Nadeem ^a   Zaman, Shakeela ^b   Asghar, Aneela ^c   Javed, Khursheed ^a   Shahzad, Faheem ^a   Zafar, Abu ^d   Nagi, Abdul Hanan ^a  

^a UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

^b CHILDREN S HOSPITAL   (Pakistan)

^c Sahiwal Medical College   (Pakistan)

^d Amin Hayat Memorial Diabetic Centre   (Pakistan)

Author keywords

Cytokine; Diabetes mellitus; Inflammation; Retinopathy

Indexed keywords

HEMOGLOBIN A1C; INTERLEUKIN 17; INTERLEUKIN 6;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC PATIENT; DIABETIC RETINOPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; BLOOD; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK FACTOR; YOUNG ADULT;

ADULT; AGED; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; HUMANS; INTERLEUKIN-17; INTERLEUKIN-6; MALE; MIDDLE AGED; RISK FACTORS; YOUNG ADULT;

EID: 84902131816     PISSN: 17351383     EISSN: 1735367X     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010; 87:4-14
2. Chhutto M.A, Qadar Habib-ur-R, Abro H.A, Shaikh M.A, Sheikh B.A, Sheikh N, et al. Awareness of diabetes mellitus and its complications in diabetic patients. Medical Channel. 2009; 4:153-6
3. Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res. 2007; 125:217-30
4. Qidwai W, Ashfaq T. Imminent epidemic of diabetes mellitus in Pakistan: Issues and challenges for health care providers. JLUMHS. 2010; 9:112-3
5. Singh R, Shaw J, Zimmet P. Epidemiology of childhood type 2 diabetes in the developing world. Pediatr Diabetes. 2004; 5:154-68
6. Tam VH, Lam EP, Chu BC, Tse KK, Fung LM. Incidence and progression of diabetic retinopathy in Homg Kong Chinese with type 2 diabetes mellitus. J Diabetes Complications. 2009; 23:185-93
7. Jamal-u-Din, Qureshi MB, Khan AJ, Khan MD, Ahmad K. Prevalence of diabetic retinopathy among individuals screened positive for diabetes in five community-based eye camps in northern Karachi Pakistan. J Ayub Med Coll Abbotabad. 2006; 18:40-3
8. Funatsu H, Yamashita H, Noma H, Mimura T, Nakamura S, Sakata K, et al. Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients. Graefes Arch Clin Exp Ophthalmol. 2005; 243:3-8
9. Meleth AD, Agron E, Chan CC, Reed GF, Arora K, Byrnes G, et al. Serum inflammatory markers in diabetic retinopathy. Inves Ophthalmol Vis Sci. 2005; 46:4295-301
10. Rachitskaya AV, Hansen AM, Horai R, Zhuqing L, Villasmil R, Luger D, et al. Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and RORγt and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6 Independent Fashion. J Immunol. 2008; 180: 5167-71
11. Voo KS, Wang YH, Santori FR, Boggiano C, Wang YH, Arima K, et al. Identification of IL-17 producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci. USA. 2009; 106; 4793-8
12. Honkanen J, Nieminen JK, Gao R, Luopajarvi K, Salo HM, Llonen J, et al. IL-17 Immunity in Human Type 1 Diabetes. J Immunol. 2010; 185:1959-67
13. Grajewski RS, Hansen AM, Agarwal RK, Kronenberg M, Sidobre S, Su SB, et al. Activation of iNKT Cells Ameliorates Experimental Ocular Autoimmunity By A Mechanism Involving Innate INF-γ Production and Dampening of the Adaptive Th1 and Th17 Responses. J Immunol. 2008. 181; 7:4791-7
14. Yoshimura T, Sonoda KH, Ohguro N, Ohsugi Y, Ishibashi T, Cua DJ, et al. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology. 2009; 48:347-54
15. Ohta K, Yamagami S, Taylor AW, Streilein JW. IL-6 Antagonizes TGF-beta and abolishes Immune Privilege in Eyes with Endotoxin-Induced Uveitis. Invest Ophthalmol Vis Sci. 2000; 41:2591-9
16. Akram J, Aamir AU, Basit A, Qureshi MS, Mehmood T, Shahid SK, et al. Prevalence of peripheral arterial disease in type 2 diabetes in Pakistan. J Pak Med Assoc. 2011; 61:644-8
17. Ahmadani MY, Fawwad A, Basit A, Hydrie ZI. Microalbuminuria Prevalence Study in Hypertensive Patients with Type 2 Diabetes in Pakistan. J Ayub Med Coll Abbottabad. 2008; 20:117-20
18. Khan S, Abbas M, Habib F, Khattak I.H, Iqbal. Prevalence of diabetes mellitus in Mirpur and Kotli districts of Azad Jammu & Kashmir (AJ&K). Sarhad J Agric. 2007; 23:1141-3
19. Silverman BL, Metzger BE, Cho NH, Loeb CA. Impaired glucose tolerance in adolescent offspring of diabetic mothers. Relationship to fetal hyperinsulinism. Diabetic Care. 1995; 18:611-7
20. Zhang X, Saaddine JB, Chou CF, Coteh MF, Cheng YJ, Geiss LS, et al. Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA. 2010; 304:649-56
21. Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, et al. Prevalence of Diabetes among Men and Women in China. N Engl J Med. 2010; 362:1090-101
22. Seeman T, Merkin SS, Crimmins E, Koretz B, Karalamangla A. Education, income and ethnic differences in cumulative biological risk profiles in a national sample of US adults. NHANES III (1988-1994). Soc Sci Med. 2008; 66:72-87
23. Mysliwiec M, Balcerska A, Zorena K, Mysliwska J, Lipowski P, Raczynska K. The role of vascular endothelial growth factor alpha and interleukin-6 in pathogenesis of diabetic retinopathy. Diabetes Res Clin Pract. 2008; 79:141-6
24. Mocan MC, Kadayifcilar S, Eldem B. Elevated intravitreal interleukin-6 levels in patients with proliferative diabetic retinopathy. Can J Ophthalmol. 2006; 4:747-52
25. Nakamuura N, Hasegawa G, Obayashi H, Yamazaki M, Ogata M, Nakano K, et al. Increased concentration of pentosidine, an advanced glycation end product, and interleukin-6 in the vitreous of patients with proliferative diabetic retinopathy. Diabetic Res Clin Pract. 2003; 61:93-101
26. Doganay S, Evereklioglu C, Er H, Tukoz Y, Serving A, Mehmet N, et al. Comparison of serum NO, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus. Eye. 2002; 16:163-70
27. Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002; 106:2067-72
28. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006; 116:1793-801
29. DiCosmo BF, Picarella D, Flavell RA. Local production of human IL-6 promotes insulinitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice. Int Immunol. 1994; 6:1829-37
30. Hermann C, Krikovszky D, Fust G, Kovacs M, Korner A, Szabo A, et al. Association between interleukin-6 polymorphism and age-at-onset of type-1 diabetes. Epistatic influences of the tumor necrosis factor-α and interleukin-1β polymorphism. Eur Cytokine Netw. 2005; 16:277-81
31. Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, et al. IL-17A Producing γδ T and Th17 Lymphocytes Mediate Lung Inflammation but not Fibrosis in Experimental Silicosis. J Immunol. 2010; 184:6367-77
32. Lv L, Pan K, Li XD, She KL, Zhao JJ, Wang W, et al. The Accumulation and Prognosis Value of Tumor Infiltrating IL-17 Producing Cells in Esophageal Squamous Cell Carcinoma. PLoS one. 2011; 6:e18219
33. Dong G, Ye R, Shi W, Liu S, Wang T, Yang X, et al. IL-17 induces autantibody overproduction and peripheral blood monomuclear cell overexpression of IL-6 in lupus nephritis patients. Chin Med J. 2003; 116:543-8
34. Zeng C, Shi X, Zhang B, Liu H, Zhang L, Ding W, et al. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med. 2012; 90:175-86
35. Chi W, Zhu S, Yang P, Chen L. CD4 T cells from behcet patients produce high levels of IL-17. Eye Sci. 2011; 26:65-9.