Association between interleukin-6 polymorphism and age-at-onset of type 1 diabetes. Epistatic influences of the tumor necrosis factor-α and interleukin-1β polymorphisms

European Cytokine Network

Volumn 16, Issue 4, 2005, Pages 277-281

  Hermann, Csaba ^a,c   Krikovszky, Dóra ^b   Füst, George ^a   Kovács, Margit ^a   Körner, Anna ^a   Szabó, András ^a   Vannay, Ádám ^b   Madácsy, László ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c Hungarian Academy of Sciences ^*  (Hungary)

Author keywords

Age at onset; Interleukin 1 ; Interleukin 6; Polymorphism; Tumor necrosis factor ; Type 1 diabetes mellitus

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ALLELE; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENETIC EPISTASIS; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; ONSET AGE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; EPISTASIS, GENETIC; FEMALE; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 35848942145     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev 1988; 14: 129.
2. Dahlen E, Dawe K, Ohlsson L, Hedlund G. Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse. J Immunol 1998; 160: 3585.
3. Toyoda H, Formby B, Magalong D, Redford A, Chan E, Takei S, Charles MA. In situ islet cytokine gene expression during development of type I diabetes in the non-obese diabetic mouse. Immu nol Lett 1994; 39: 283.
4. Stephens LA, Thomas HE, Ming L, Grell M, Darwiche R, Volodin L, Kay TW. Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells. Endocrinology 1999; 140: 3219.
5. Corbett JA, McDaniel ML. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J Exp Med 1995; 181: 559.
6. Privat SJ, Oo A, Waterbury LD. Production of interleukin-6, but not interleukin-8, induced by TNF-alpha or IL-1 beta in human fibroblast-like synoviocyte increases over cell passage. Proc West Pharmacol Soc 2001; 44: 9.
7. Campbell IL, Hobbs MV, Dockter J, Oldstone MB, Allison J. Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice. Am J Pathol 1994; 145: 157.
8. Erbagci AB, Tarakcioglu M, Coskun Y, Sivasli E, Sibel Namiduru E. Mediators of inflammation in children with type I diabetes mellitus: cytokines in type I diabetic children. Clin Biochem 2001; 34: 645.
9. Foulis AK, Farquharson MA, Meager A. Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus. Lancet 1987; 2: 1423.
10. DiCosmo BF, Picarella D, Flavell RA. Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice. Int Immunol 1994; 6: 1829.
11. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
12. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102: 1369.
13. Day CP, Grove J, Daly AK, Stewart MW, Avery PJ, Walker M. Tumour necrosis factor-alpha gene promoter polymorphism and decreased insulin resistance. Diabeiologia 1998; 41: 430.
14. Moos V, Rudwaleit M, Herzog V, Hohlig K, Sieper J, Muller B. Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis. Arthritis Rheum 2000; 43: 2417.
15. Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 1993; 54: 1.
16. Starkie R, Ostrowski SR, Jauffred S, Febbraio M, Pedersen BK. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J 2003; 17: 884.
17. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990; 265: 621-36.
18. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000; 101: 1767-72.
19. Campbell IL, Hobbs MV, Dockter J, Oldstone MB, Allison J. Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice. Am J Pathol 1994; 145: 157.
20. DiCosmo BF, Picarella D, Flavell RA. Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice. Int Immunol 1994; 6: 1829.
21. Targher G, Zenari L, Bertolini L, Muggeo M, Zoppini G. Elevated levels of interleukin-6 in young adults with type 1 diabetes without clinical evidence of microvascular and macrovascular complications. Diabetes Care 2001; 24: 956.
22. Devaraj S, Venugopal SK, Singh U, Jialal I. Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-(alpha) and -{beta}. Diabetes 2005; 54: 85.
23. Watanabe E, Hirasawa H, Oda S, Matsuda K, Hatano M, Tokuhisa T. Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor-and interleukin-1-related gene polymorphisms. Crit Care Med 2005; 33: 89.
24. Amosova EN, Shpak YV, Nedozhdij AV, Produsevich LV. Proinflammatory cytokine levels in patients with diastolic heart failure. Kardiol Pol 2004; 61: 17.
25. Privat SJ, Oo A, Waterbury LD. Production of interleukin-6, but not interleukin-8, induced by TNF-alpha or IL-I beta in human fibroblast-like synoviocyte increases over cell passage. Proc West Pharmacol Soc 2001; 44: 9.
26. Lo HC, Lin SC, Wang YM. The relationship among serum cytokines, chemokine, nitric oxide, and leptin in children with type 1 diabetes mellitus. Clin Biochem 2004; 37: 666.
27. Erbagci AB, Tarakcioglu M, Coskun Y, Sivasli E, Sibel Namiduru E. Mediators of inflammation in children with type I diabetes mellitus: cytokines in type I diabetic children. Clin Biochem 2001; 34: 645.
28. Jahromi MM, Millward BA, Demaine AG. A polymorphism in the promoter region of the gene for interleukin-6 is associated with susceptibility to type 1 diabetes mellitus. J Interferon Cytokine Res 2000; 20: 885.
29. Kristiansen OP, Nolsoe RL, Larsen L, Gjesing AM, Johannesen J, Larsen ZM. DIEGG; DSGD. Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. Hum Mol Genet 2003; 12: 1101.
30. Gillespie KM, Nolsoe R, Betin VM, Kristiansen OP, Bingley PJ, Mandrup-Poulsen T. Is puberty an accelerator of type 1 diabetes in IL6-174CC females? Diabetes 2005; 54: 1245-8.
31. Privat SJ, Oo A, Waterbury LD. Production of interleukin-6, but not interleukin-8, induced by TNF-alpha or IL-1 beta in human fibroblast-like synoviocyte increases over cell passage. Proc West Pharmacol Soc 2001; 44: 9.
32. DiCosmo BF, Picarella D, Flavell RA. Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice. Int Immunol 1994; 6: 1829.
33. Choi SE, Choi KM, Yoon IH, Shin JY, Kim JS, Park WY, Han DJ, Kim SC, Ahn C, Kim JY, Hwang ES, Cha CY, Szot GL, Yoon KH, Park CG. IL-6 protects pancreatic islet beta cells from proinflammatory cytokines-induced cell death and functional impairment in vitro and in vivo. Transpl Immunol 2004; 13: 43.
34. Demeter J, Messer G, Rajczy K, Patscht K, Pénzes M, Kenéz A. Hazai adatok a TNF-α, az IL-α, az IL-6 promoter és az IL-1 receptor-antagonista DNS-szintü polimorfizmusának megoszlásáról és ezen polimorfizmusok jelentösége fertözö, autoimmun és malignus betegségekben. Magy Belorv Arch 2000; 53: 185.
35. Krikovszky D, Vasarhelyi B, Treszl A, Korner A, Tordai A, Tulassay T, Madacsy L. Genetic polymorphism of interleukin-1beta is associated with risk of type 1 diabetes mellitus in children. Eur J Pediatr 2002; 161: 507.