Topiramate as an adjuvant treatment for obsessive compulsive symptoms in patients with bipolar disorder: A randomized double blind placebo controlled clinical trial

Journal of Affective Disorders

Volumn 166, Issue , 2014, Pages 201-205

  Sahraian, Ali ^a   Bigdeli, Mohammad ^a   Ghanizadeh, Ahmad ^a,b   Akhondzadeh, Shahin ^c  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bipolar disorder; Clinical trial; Obsessive compulsive disorder; Therapeutics; Topiramate

Indexed keywords

CLONAZEPAM; LITHIUM; OLANZAPINE; PLACEBO; TOPIRAMATE; BENZODIAZEPINE DERIVATIVE; FRUCTOSE; LITHIUM DERIVATIVE; NEUROPROTECTIVE AGENT; SEROTONIN UPTAKE INHIBITOR; TRANQUILIZER;

ADJUVANT THERAPY; ADULT; ARTICLE; BIPOLAR I DISORDER; CLINICAL ARTICLE; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; DSM-IV-TR; FATIGUE; FEMALE; HUMAN; INCREASED APPETITE; LIBIDO DISORDER; MALE; MEDICATION COMPLIANCE; NAUSEA; OBSESSIVE COMPULSIVE DISORDER; OUTCOME ASSESSMENT; PARALLEL DESIGN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; TREATMENT RESPONSE; XEROSTOMIA; YALE BROWN OBSESSIVE COMPULSIVE SCALE; ANALOGS AND DERIVATIVES; BIPOLAR DISORDER; DRUG COMBINATION; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PSYCHOLOGY; TREATMENT OUTCOME;

ADULT; ANTIMANIC AGENTS; BENZODIAZEPINES; BIPOLAR DISORDER; CLONAZEPAM; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FRUCTOSE; HUMANS; LITHIUM COMPOUNDS; MALE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; OBSESSIVE-COMPULSIVE DISORDER; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME;

EID: 84902128590     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.05.015     Document Type: Article

References (32)

1. P. Alonso, M. Gratacos, C. Segalas, G. Escaramis, E. Real, M. Bayes, J. Labad, C. Lopez-Sola, X. Estivill, and J.M. Menchon Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder J. Psychiatry Neurosci. 37 4 2012 273 281
2. H.A. Berlin, L.M. Koran, M.A. Jenike, N.A. Shapira, W. Chaplin, S. Pallanti, and E. Hollander Double-blind, placebo-controlled trial of topiramate augmentation in treatment-resistant obsessive-compulsive disorder J. Clin. Psychiatry 72 5 2011 716 721
3. A. Bruno, D. Riganello, and A. Marino Treatment with aripiprazole and topiramate in an obese subject with borderline personality disorder, obsessive-compulsive symptoms and bulimia nervosa: a case report Cases J. 2 2009 7288
4. L. Darby, M. Agius, and R. Zaman Co-morbidity of bipolar affective disorder and obsessive compulsive disorder in a Bedford community psychiatry team Psychiatr Danubina 23 Suppl. 1 2011 S130 S133
5. S.I. Deutsch, B.L. Schwartz, R.B. Rosse, J. Mastropaolo, C.L. Marvel, and A.L. Drapalski Adjuvant topiramate administration: a pharmacologic strategy for addressing NMDA receptor hypofunction in schizophrenia Clin. Neuropharmacol. 26 4 2003 199 206 (Pubitemid 36951066)
6. K. Gao, D.E. Kemp, S.J. Ganocy, D.J. Muzina, G. Xia, R.L. Findling, and J.R. Calabrese Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorder Bipolar Disord. 10 8 2008 907 915
7. F.S. Goes, M.G. McCusker, O.J. Bienvenu, D.F. Mackinnon, F.M. Mondimore, B. Schweizer, National Institute of Mental Health Genetics Initiative Bipolar Disorder, J.R. Depaulo, and J.B. Potash Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder Psychol. Med. 42 7 2012 1449 1459
8. W.K. Goodman, L.H. Price, S.A. Rasmussen, C. Mazure, R.L. Fleischmann, C.L. Hill, G.R. Heninger, and D.S. Charney The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability Arch. Gen. Psychiatry 46 11 1989 1006 1011 (Pubitemid 19278229)
9. E. Hollander, and B. Dell'Osso Topiramate plus paroxetine in treatment-resistant obsessive-compulsive disorder Int. Clin. Psychopharmacol. 21 3 2006 189 191 (Pubitemid 43740312)
10. G. Joshi, E. Mick, J. Wozniak, D. Geller, J. Park, S. Strauss, and J. Biederman Impact of obsessive-compulsive disorder on the antimanic response to olanzapine therapy in youth with bipolar disorder Bipolar Disord. 12 2 2010 196 204
11. A. Koyuncu, R. Tukel, I. Ozyildirim, H. Meteris, and O. Yazici Impact of obsessive-compulsive disorder comorbidity on the sociodemographic and clinical features of patients with bipolar disorder Compr. Psychiatry 51 3 2010 293 297
12. S. Kruger, P. Braunig, and R.G. Cooke Comorbidity of obsessive-compulsive disorder in recovered inpatients with bipolar disorder Bipolar Disord. 2 1 2000 71 74
13. S.F. Kushner, A. Khan, R. Lane, and W.H. Olson Topiramate monotherapy in the management of acute mania: results of four double-blind placebo-controlled trials Bipolar Disord. 8 1 2006 15 27 (Pubitemid 43356017)
14. N.T. Lemke, and J.R. Bustillo Clozapine-induced obsessive-compulsive symptoms in bipolar disorder Am. J. Psychiatry 170 8 2013 930
15. G.S. Leverich, L.L. Altshuler, M.A. Frye, T. Suppes, S.L. McElroy, P.E. Keck Jr., R.W. Kupka, K.D. Denicoff, W.A. Nolen, H. Grunze, M.I. Martinez, and R.M. Post Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers Am. J. Psychiatry 163 2 2006 232 239 (Pubitemid 44480842)
16. P.V. Magalhaes, N.S. Kapczinski, and F. Kapczinski Correlates and impact of obsessive-compulsive comorbidity in bipolar disorder Compr. Psychiatry 51 4 2010 353 356
17. M.R. Mohammadi, A. Ghanizadeh, and R. Moini Lifetime comorbidity of obsessive-compulsive disorder with psychiatric disorders in a community sample Depress. Anxiety 24 8 2007 602 607 (Pubitemid 350274862)
18. M.R. Mohammadi, A. Ghanizadeh, M. Rahgozar, A.A. Noorbala, H. Davidian, H.M. Afzali, H.R. Naghavi, S.A. Yazdi, S.M. Saberi, B. Mesgarpour, S. Akhondzadeh, J. Alaghebandrad, and M. Tehranidoost Prevalence of obsessive-compulsive disorder in Iran BMC Psychiatry 4 2004 2
19. A. Mowla, A.M. Khajeian, A. Sahraian, A.H. Chohedri, and F. Kashkoli Topiramate augmentation in resistant OCD: a double-blind placebo-controlled clinical trial CNS Spectr 2010
20. C. Ozkara, M. Ozmen, A. Erdogan, and I. Yalug Topiramate related obsessive-compulsive disorder Eur. Psychiatry 20 1 2005 78 79 (Pubitemid 40092398)
21. C. Pittenger, M.H. Bloch, and K. Williams Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment Pharmacol. Ther. 132 3 2011 314 332
22. K.N. Roy Chengappa, L.K. Schwarzman, J.F. Hulihan, J. Xiang, and N.R. Rosenthal Adjunctive topiramate therapy in patients receiving a mood stabilizer for bipolar I disorder: a randomized, placebo-controlled trial J. Clin. Psychiatry 67 11 2006 1698 1706 (Pubitemid 44955149)
23. G. Rubio, M.A. Jimenez-Arriero, I. Martinez-Gras, J. Manzanares, and T. Palomo The effects of topiramate adjunctive treatment added to antidepressants in patients with resistant obsessive-compulsive disorder J. Clin. Psychopharmacol. 26 3 2006 341 344 (Pubitemid 43804634)
24. E.F. Saunders, K.D. Fitzgerald, P. Zhang, and M.G. McInnis Clinical features of bipolar disorder comorbid with anxiety disorders differ between men and women Depress. Anxiety 29 8 2012 739 746
25. N.M. Simon, M.W. Otto, S.R. Wisniewski, M. Fossey, K. Sagduyu, E. Frank, G.S. Sachs, A.A. Nierenberg, M.E. Thase, and M.H. Pollack Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) Am. J. Psychiatry 161 12 2004 2222 2229 (Pubitemid 39587287)
26. N.M. Simon, A.K. Zalta, M.W. Otto, M.J. Ostacher, D. Fischmann, C.W. Chow, E.H. Thompson, J.C. Stevens, C.M. Demopulos, A.A. Nierenberg, and M.H. Pollack The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder J. Psychiatr. Res. 41 3-4 2007 255 264 (Pubitemid 44856732)
27. C.M. Swartz, and W.W. Shen Is episodic obsessive compulsive disorder bipolar? A report of four cases. J. Affect. Disord. 56 1 1999 61 66
28. J. Thuile, C. Even, and J.D. Guelfi Topiramate may induce obsessive-compulsive disorder Psychiatry Clin. Neurosci. 60 3 2006 394 (Pubitemid 43736408)
29. M. Van Ameringen, C. Mancini, B. Patterson, and M. Bennett Topiramate augmentation in treatment-resistant obsessive-compulsive disorder: a retrospective, open-label case series Depress. Anxiety 23 1 2006 1 5
30. K. Vasudev, K. Macritchie, J. Geddes, S. Watson, and A. Young Topiramate for acute affective episodes in bipolar disorder Cochrane Database Syst. Rev. 1 2006 (CD003384)
31. D.J. Vinkers, and N.J. van der Wee Topiramate augmentation in treatment-resistant obsessive-compulsive disorder Tijdschr Psychiatr 50 11 2008 747 750
32. K. Wu, G.L. Hanna, D.R. Rosenberg, and P.D. Arnold The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder Pharmacol. Biochem. Behav. 100 4 2012 726 735