Two missense mutations, E123Q and K151E, identified in the ERG11 allele of an azole-resistant isolate of Candida kefyr recovered from a stem cell transplant patient for acute myeloid leukemia

Medical Mycology Case Reports

Volumn 5, Issue 1, 2014, Pages 12-15

  Couzigou, Célia ^a,b,c   Gabriel, Frédéric ^a,b,c   Biteau, Nicolas ^a,b   Fitton Ouhabi, Valérie ^a,b   Noël, Thierry ^a,b   Accoceberry, Isabelle ^a,b,c  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b University Victor Segalen   (France)

^c BORDEAUX UNIVERSITY HOSPITAL   (France)

Author keywords

Azole resistance; Candida kefyr; ERG11; Kluyveromyces marxianus; Single nucleotide polymorphism

Indexed keywords

AMIKACIN; AMINO ACID; ANAGRELIDE; BASILIXIMAB; CASPOFUNGIN; CEFTRIAXONE; CIPROFLOXACIN; CORTICOSTEROID; E123Q AMINO ACID; FLUCONAZOLE; FUROSEMIDE; GALACTOMANNAN; HYDROXYUREA; IMIPENEM; INOLIMOMAB; K151E AMINO ACID; PIPERACILLIN PLUS TAZOBACTAM; PIPOBROMAN; RAPAMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN; VORICONAZOLE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; AMINO ACID SUBSTITUTION; ANTIBIOTIC THERAPY; ANTIFUNGAL RESISTANCE; ARTICLE; ASTHENIA; BLOOD CULTURE; BLOOD EXAMINATION; BONE MARROW BIOPSY; CANDIDA ALBICANS; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DIGESTIVE SYSTEM FUNCTION DISORDER; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ERG11 GENE; FEMALE; FEVER; FUNGUS GROWTH; FUNGUS ISOLATION; GENE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HEMOGLOBIN BLOOD LEVEL; HUMAN; KLUYVEROMYCES MARXIANUS; LUNG ASPERGILLOSIS; LUNG EDEMA; LUNG NODULE; MISSENSE MUTATION; MOLECULAR CLONING; MYELOFIBROSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEPTIC SHOCK; THROMBOCYTHEMIA;

EID: 84902127320     PISSN: 22117539     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mmcr.2014.04.002     Document Type: Article

References (19)

1. D. Sohier, A.-S.L. Dizes, D. Thuault, C. Neuveglise, E. Coton, and S. Casaregola Important genetic diversity revealed by inter-LTR PCR fingerprinting of Kluyveromyces marxianus and Debaryomyces hansenii strains from French traditional cheeses Dairy Sci Technol 89 6 2009 569 581
2. C.W.M. Reuter, M.A. Morgan, F.-C. Bange, F. Gunzer, M. Eder, and B. Hertenstein et al. Candida kefyr as an emerging pathogen causing nosocomial bloodstream infections in neutropenic leukemia patients Clin Infect Dis 41 9 2005 1365 1366 (Pubitemid 41532689)
3. B. Sendid, C. Lacroix, and M.-E. Bougnoux Is Candida kefyr an emerging pathogen in patients with oncohematological diseases? Clin Infect Dis 43 5 2006 666 667 (Pubitemid 44267134)
4. A. Fekkar, I. Meyer, J.Y. Brossas, E. Dannaoui, M. Palous, and M. Uzunov et al. Rapid emergence of echinocandin resistance during Candida kefyr fungemia treatment with caspofungin Antimicrob Agents Chemother 57 5 2013 2380 2382
5. M.M. Lane, N. Burke, R. Karreman, K.H. Wolfe, C.P. O'Byrne, and J.P. Morrissey Physiological and metabolic diversity in the yeast Kluyveromyces marxianus Antonie van Leeuwenhoek 100 4 2011 507 519
6. T. Noël The cellular and molecular defense mechanisms of the Candida yeasts against azole antifungal drugs J Mycol Med 22 2 2012 173 178
7. H. Jeong, D.-H. Lee, S.H. Kim, H.-J. Kim, K. Lee, and J.Y. Song et al. Genome sequence of the thermotolerant yeast Kluyveromyces marxianus var. marxianus KCTC 17555 Eukaryot Cell 11 12 2012 1584 1585
8. F. Tissot, F. Lamoth, P.M. Hauser, C. Orasch, U. Flückiger, and M. Siegemund et al. β-Glucan antigenemia anticipates diagnosis of blood culture - negative intraabdominal candidiasis Am J Respir Crit Care Med 188 9 2013 1100 1109
9. S.F. Altschul, T.L. Madden, A.A. Schäffer, J. Zhang, Z. Zhang, and W. Miller et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Nucleic Acids Res 25 17 1997 3389 3402 (Pubitemid 27359211)
10. J. Pustell, and F.C. Kafatos A high speed, high capacity homology matrix: zooming through SV40 and polyoma Nucleic Acids Res 10 15 1982 4765
11. B. Dujon, D. Sherman, G. Fischer, P. Durrens, S. Casaregola, and I. Lafontaine et al. Genome evolution in yeasts Nature 430 6995 2004 35 44 (Pubitemid 38915217)
12. C. Renaudat, K. Sitbon, M. Desnos-Ollivier, A. Fontanet, S. Bretagne, and O. Lortholary et al. Candidemia in the Paris area (France): data from the YEASTS program (2002-2010) Bull Epidemiolog Hebd 12-13 2013 125 128
13. A. Gomez-Lopez, D. Pan, I. Cuesta, A. Alastruey-Izquierdo, J.L. Rodriguez-Tudela, and M. Cuenca-Estrella Molecular identification and susceptibility profile in vitro of the emerging pathogen Candida kefyr Diagn Microbiol Infect Dis 66 1 2010 116 119
14. M.A. Pfaller, and D.J. Diekema Progress in antifungal susceptibility testing of Candida spp. by use of clinical and laboratory standards institute broth microdilution methods, 2010 to 2012 J Clin Microbiol 50 9 2012 2846
15. P. Marichal, L. Koymans, S. Willemsens, D. Bellens, P. Verhasselt, and W. Luyten et al. Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans Microbiology 145 10 1999 2701 2713 (Pubitemid 29485885)
16. L. Xiao, V. Madison, A.S. Chau, D. Loebenberg, R.E. Palermo, and P.M. McNicholas Three-dimensional models of wild-type and mutated forms of cytochrome P450 14α-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding Antimicrob Agents Chemother 48 2 2004 568 574 (Pubitemid 38141718)
17. F. Morio, C. Loge, B. Besse, C. Hennequin, and P. Le Pape Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature Diagn Microbiol Infect Dis 66 4 2010 373 384
18. B. Favre, M. Didmon, and N.S. Ryder Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans Microbiology 145 10 1999 2715 2725 (Pubitemid 29485886)
19. G.H. Goldman, M.E. Da Silva Ferreira, E. Dos Reis Marques, M. Savoldi, D. Perlin, and S. Park et al. Evaluation of fluconazole resistance mechanisms in Candida albicans clinical isolates from HIV-infected patients in Brazil Diagn Microbiol Infect Dis 50 1 2004 25 32 (Pubitemid 39360259)