Cardiac mucosa at the gastro-oesophageal junction: Indicator of gastro-oesophageal reflux disease? Data from a prospective central European multicentre study on histological and endoscopic diagnosis of oesophagitis (histoGERD trial)

Histopathology

Volumn 65, Issue 1, 2014, Pages 81-89

  Langner, Cord ^a   Schneider, Nora I ^a   Plieschnegger, Wolfgang ^b   Schmack, Bertram ^c   Bordel, Hartmut ^d   Höfler, Bernd ^a   Eherer, Andreas J ^a   Wolf, Eva Maria ^a   Rehak, Peter ^a   Vieth, Michael ^e  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b Academic Teaching Hospital   (Australia)

^c Private Practice   (Australia)

^d Dermatologist in Private Practice   (Germany)

^e INSTITUTE OF PATHOLOGY   (Germany)

Author keywords

Gastric cardia; Gastro oesophageal junction; Metaplasia; Prevalence; Reflux disease

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; BASAL CELL; CARDIAC MUCOSA; CELL HYPERPLASIA; COLUMNAR EPITHELIUM; DIARRHEA; DISEASE SEVERITY; ENDOSCOPE; EOSINOPHIL; EPIGASTRIC DISCOMFORT; EPIGASTRIC PAIN; ESOPHAGITIS; ESOPHAGOSCOPY; ESOPHAGUS BIOPSY; FEMALE; FLEXIBLE GASTROSCOPE; GASTROESOPHAGEAL REFLUX; GASTROSCOPE; GASTROSCOPY; GOBLET CELL; HEARTBURN; HELICOBACTER INFECTION; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTERCELLULAR SPACE; INTESTINE METAPLASIA; LOWER ESOPHAGUS SPHINCTER; MAJOR CLINICAL STUDY; MALABSORPTION; MALE; MONONUCLEAR CELL; MUCOSA; MUCOUS CELL; MULTICENTER STUDY; NEUTROPHIL; PRIORITY JOURNAL; PROSPECTIVE STUDY; SQUAMOUS EPITHELIUM; STOMACH BIOPSY; CARDIA; CHILD; CLINICAL TRIAL; MIDDLE AGED; PATHOLOGY; REFLUX ESOPHAGITIS; STOMACH MUCOSA; VERY ELDERLY; YOUNG ADULT;

HELICOBACTER;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARDIA; CHILD; ESOPHAGITIS, PEPTIC; ESOPHAGOGASTRIC JUNCTION; FEMALE; GASTRIC MUCOSA; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84902085611     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/his.12367     Document Type: Article

References (40)

1. Toghanian S, Johnson DA, Stålhammar NO, Zerbib F. Burden of gastro-esophageal reflux disease in patients with persistent and intense symptoms despite proton pump inhibitor therapy: a post hoc analysis of the 2007 national health and wellness survey. Clin. Drug. Investig. 2011; 31; 703-715.
2. Vakil N. Disease definition, clinical manifestations, epidemiology and natural history of GERD. Best Pract. Res. Clin. Gastroenterol. 2010; 24; 759-764.
3. Tytgat GN. Recent developments in gastroesophageal reflux disease and Barrett's esophagus: ANNO 2012. J. Dig. Dis. 2012; 13; 291-295.
4. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am. J. Gastroenterol. 2006; 101; 1900-1920.
5. Fiocca R, Mastracci L, Riddell R et al. Development of consensus guidelines for the histologic recognition of microscopic esophagitis in patients with gastroesophageal reflux disease: the Esohisto project. Hum. Pathol. 2010; 41; 223-231.
6. Lagergren J, Bergström R, Lindgren A, Nyrén O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N. Engl. J. Med. 1999; 340; 825-831.
7. Paull A, Trier JS, Dalton MD, Camp RC, Loeb P, Goyal RK. The histologic spectrum of Barrett's esophagus. N. Engl. J. Med. 1976; 295; 476-480.
8. Chandrasoma PT, Lokuhetty DM, Demeester TR et al. Definition of histopathologic changes in gastroesophageal reflux disease. Am. J. Surg. Pathol. 2000; 24; 344-351.
9. Kilgore SP, Ormsby AH, Gramlich TL et al. The gastric cardia: fact or fiction? Am. J. Gastroenterol. 2000; 95; 921-924.
10. Zhou H, Greco MA, Daum F, Kahn E. Origin of cardiac mucosa: ontogenic consideration. Pediatr. Dev. Pathol. 2001; 4; 358-363.
11. Glickman JN, Fox V, Antonioli DA, Wang HH, Odze RD. Morphology of the cardia and significance of carditis in pediatric patients. Am. J. Surg. Pathol. 2002; 26; 1032-1039.
12. De Hertogh G, Van Eyken P, Ectors N, Tack J, Geboes K. On the existence and location of cardiac mucosa: an autopsy study in embryos, fetuses, and infants. Gut 2003; 52; 791-796.
13. Derdoy JJ, Bergwerk A, Cohen H, Kline M, Monforte HL, Thomas DW. The gastric cardia: to be or not to be? Am. J. Surg. Pathol. 2003; 27; 499-504.
14. Park YS, Park HJ, Kang GH, Kim CJ, Chi JG. Histology of gastroesophageal junction in fetal and pediatric autopsy. Arch. Pathol. Lab. Med. 2003; 127; 451-455.
15. Chandrasoma PT, Der R, Ma Y, Dalton P, Taira M. Histology of the gastroesophageal junction: an autopsy study. Am. J. Surg. Pathol. 2000; 24; 402-409.
16. Sarbia M, Donner A, Gabbert HE. Histopathology of the gastroesophageal junction: a study on 36 operation specimens. Am. J. Surg. Pathol. 2002; 26; 1207-1212.
17. Öberg S, Peters JH, DeMeester TR et al. Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease. Ann. Surg. 1997; 226; 522-530.
18. Lord RV, Wickramasinghe K, Johansson JJ, Demeester SR, Brabender J, Demeester TR. Cardiac mucosa in the remnant esophagus after esophagectomy is an acquired epithelium with Barrett's-like features. Surgery 2004; 136; 633-640.
19. Lenglinger J, Ringhofer C, Eisler M et al. Histopathology of columnar-lined esophagus in patients with gastroesophageal reflux disease. Wien. Klin. Wochenschr. 2007; 119; 405-411.
20. Chandrasoma P, Wijetunge S, Demeester SR, Hagen J, Demeester TR. The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux disease. Am. J. Surg. Pathol. 2010; 34; 1574-1581.
21. Chandrasoma P, Wijetunge S, Ma Y, Demeester S, Hagen J, Demeester T. The dilated distal esophagus: a new entity that is the pathologic basis of early gastroesophageal reflux disease. Am. J. Surg. Pathol. 2011; 35; 1873-1881.
22. von Elm E, Altman DG, Egger M et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J. Clin. Epidemiol. 2008; 61; 344-349.
23. Lundell LR, Dent J, Bennett JR et al. Endoscopic assessment of esophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999; 45; 172-180.
24. Hongo M. Minimal changes in reflux esophagitis: red ones and white ones. J. Gastroenterol. 2006; 41; 95-99.
25. Sharma P, Dent J, Armstrong D et al. The development and validation of an endoscopic grading system for Barrett's esophagus: the Prague C & M criteria. Gastroenterology 2006; 13; 1392-1399.
26. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am. J. Surg. Pathol. 1996; 20; 1161-1181.
27. Allison PR, Johnstone AS. The esophagus lined with gastric mucous membrane. Thorax 1953; 8; 87-101.
28. Hayward J. The lower end of the esophagus. Thorax 1961; 16; 36-41.
29. Marsman WA, van Sandick JW, Tytgat GN, ten Kate FJ, van Lanschot JJ. The presence and mucin histochemistry of cardiac type mucosa at the esophagogastric junction. Am. J. Gastroenterol. 2004; 99; 212-217.
30. Chandrasoma P, Makarewicz K, Wickramasinghe K, Ma Y, Demeester T. A proposal for a new validated histological definition of the gastroesophageal junction. Hum. Pathol. 2006; 37; 40-47.
31. Chandrasoma PT, Der R, Ma Y, Peters J, Demeester T. Histologic classification of patients based on mapping biopsies of the gastroesophageal junction. Am. J. Surg. Pathol. 2003; 27; 929-936.
32. Oberg S, Johansson J, Wenner J, Walther B. Metaplastic columnar mucosa in the cervical esophagus after esophagectomy. Ann. Surg. 2002; 235; 338-345.
33. Hamilton SR, Yardley JH. Regeneration of cardiac type mucosa and acquisition of Barrett mucosa after esophagogastrostomy. Gastroenterology 1977; 72; 669-675.
34. Robertson EV, Derakhshan MH, Wirz AA et al. Central obesity in asymptomatic volunteers is associated with increased intrasphincteric acid reflux and lengthening of the cardiac mucosa. Gastroenterology 2013; 145; 730-739.
35. Chandrasoma P. Pathological basis of gastroesophageal reflux disease. World J. Surg. 2003; 27; 986-993.
36. Carr JS, Zafar SF, Saba N, Khuri FR, El-Rayes BF. Risk factors for rising incidence of esophageal and gastric cardia adenocarcinoma. J. Gastrointest. Cancer 2013; 44; 143-151.
37. Hahn HP, Blount PL, Ayub K et al. Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus. Am. J. Surg. Pathol. 2009; 33; 1006-1015.
38. Liu W, Hahn H, Odze RD, Goyal RK. Metaplastic esophageal columnar epithelium without goblet cells shows DNA content abnormalities similar to goblet cell-containing epithelium. Am. J. Gastroenterol. 2009; 104; 816-824.
39. Takubo K, Aida J, Naomoto Y et al. Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum. Pathol. 2009; 40; 65-74.
40. Chandrasoma P, Wijetunge S, DeMeester S et al. Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma. Am. J. Surg. Pathol. 2012; 36; 1-7.