Central obesity in asymptomatic volunteers is associated with increased intrasphincteric acid reflux and lengthening of the cardiac mucosa

Gastroenterology

Volumn 145, Issue 4, 2013, Pages 730-739

  Robertson, Elaine V ^a   Derakhshan, Mohammad H ^a   Wirz, Angela A ^a   Lee, Yeong Yeh ^a   Seenan, John Paul ^a   Ballantyne, Stuart A ^b   Hanvey, Scott L ^b   Kelman, Andrew W ^a   Going, James J ^c   McColl, Kenneth E L ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^c GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

Author keywords

Cardia Histology Intrasphincteric Reflux Overweight Cancer Risk

Indexed keywords

ABDOMINAL FAT; ADULT; AGED; ARTICLE; ASYMPTOMATIC DISEASE; CLINICAL ARTICLE; COLUMNAR EPITHELIUM; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; FLUOROSCOPY; GASTROESOPHAGEAL REFLUX; HIATUS HERNIA; HUMAN; INTESTINE METAPLASIA; LOWER ESOPHAGUS SPHINCTER; MALE; MANOMETRY; MUSCLE CONTRACTION; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PH MEASUREMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STOMACH ADENOCARCINOMA; STOMACH BIOPSY; STOMACH MUCOSA; STOMACH PH; STOMACH PRESSURE; WAIST CIRCUMFERENCE;

EID: 84884413656     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.06.038     Document Type: Article

References (29)

1. A. Steffen, M. Schulze, and T. Pischon Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition Cancer Epidemiol Biomarkers Prev 18 2009 2079 2089
2. H. Hampel, N.S. Abraham, and B. El-Serag Meta-analysis: Obesity and the risk for gastroesophageal reflux disease and its complications Ann Intern Med 143 2005 199 211
3. D.R. de Vries, M.A. van Herwaarden, and A.J. Smout Gastroesophageal pressure gradients in gastroesophageal reflux disease: relations with hiatal hernia, body mass index, and esophageal acid exposure Am J Gastroenterol 103 2008 1349 1354
4. J.E. Pandolfino, H.B. El-Serag, and Q. Zhang Obesity: a challenge to esophagogastric junction integrity Gastroenterology 130 2006 639 649
5. M.H. Derakhshan, E.V. Robertson, and J. Fletcher Mechanism of association between BMI and dysfunction of the gastro-oesophageal barrier in patients with normal endoscopy Gut 61 2012 337 343
6. J.M. Howard, P. Beddy, and D. Ennis Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma Br J Surg 97 2010 1020 1027
7. C.M. Olsen, N. Pandeya, and A.C. Green Population attributable fractions of adenocarcinoma of the esophagus and gastroesophageal junction Am J Epidemiol 174 2011 582 590
8. G.S. Cooper, T.D. Kou, and A. Chak Receipt of previous diagnoses and endoscopy and outcome from esophageal adenocarcinoma: a population-based study with temporal trends Am J Gastroenterol 104 2009 1356 1362
9. D.A. Corley, T.R. Levin, and L.A. Habel Surveillance and survival in Barrett's adenocarcinomas: a population-based study Gastroenterology 122 2002 633 640
10. A.A. Botterweck, L.J. Schouten, and A. Volovics Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries Int J Epidemiol 29 2000 645 654
11. J. Steevens, A.A. Botterweck, and M.J. Dirx Trends in incidence of oesophageal and stomach cancer subtypes in Europe Eur J Gastroenterol Hepatol 22 2010 669 678
12. G.N. Tytgat, H. Bartelink, and R. Bernards Cancer of the esophagus and gastric cardia: recent advances Dis Esophagus 17 2004 10 26
13. S. Hansen, S.E. Vollset, and M.H. Derakhshan Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status Gut 56 2007 918 925
14. M.H. Derakhshan, R. Malekzadeh, and H. Watabe Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer Gut 57 2008 298 305
15. J. Lagergren, R. Bergstrom, and A. Lindgren Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma N Engl J Med 340 1999 825 831
16. R. Der, D.D. Tsao-Wei, and T. Demeester Carditis: a manifestation of gastroesophageal reflux disease Am J Surg Pathol 25 2001 245 252
17. S. Nandurkar, and N.J. Talley Barrett's esophagus: the long and the short of it Am J Gastroenterol 94 1999 30 40
18. A.T. Clarke, A.A. Wirz, and J.J. Manning Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket Gut 57 2008 292 297
19. J.P. Seenan, A.A. Wirz, and E.V. Robertson Effect of nitrite delivered in saliva on postprandial gastro-esophageal function Scand J Gastroenterol 47 2012 387 396
20. J.N. Glickman, V. Fox, and D.A. Antonioli Morphology of the cardia and significance of carditis in pediatric patients Am J Surg Pathol 26 2002 1032 1039
21. P. Chandrasoma, S. Wijetunge, and S.R. Demeester The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux disease Am J Surg Pathol 34 2010 1574 1581
22. P. Chandrasoma Controversies of the cardiac mucosa and Barrett's oesophagus Histopathology 46 2005 361 373
23. M.E. Lean, T.S. Han, and P. Deurenberg Predicting body composition by densitometry from simple anthropometric measurements Am J Clin Nutr 63 1996 4 14
24. E.V. Robertson, Y.Y. Lee, and M.H. Derakhshan High-resolution esophageal manometry: addressing thermal drift of the manoscan system Neurogastroenterol Motil 24 2012 61 64 e11
25. M.E. Kunkel, A. Herkommer, and M. Reinehr Morphometric analysis of the relationships between intervertebral disc and vertebral body heights: an anatomical and radiographic study of the human thoracic spine J Anat 219 2011 375 387
26. M. Voutilainen, M. Farkkila, and J.P. Mecklin Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastroesophageal reflux disease. The Central Finland Endoscopy Study Group Am J Gastroenterol 94 1999 3175 3180
27. M. Cicala, S. Emerenziani, and R. Caviglia Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal relfux disease Aliment Pharmacol Ther 18 2003 605 613
28. K. Takubo, J. Aida, and Y. Naomoto Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma Hum Pathol 40 2009 65 74
29. C.J. Kelty, M.D. Gough, and Q. Van Wyk Barrett's oesophagus: intestinal metaplasia is not essential for cancer risk Scand J Gastroenterol 42 2007 1271 1274