Thalidomide ameliorates inflammation and vascular injury but aggravates tubular damage in the irradiated mouse kidney

International Journal of Radiation Oncology Biology Physics

Volumn 89, Issue 3, 2014, Pages 599-606

  Scharpfenecker, Marion ^a   Floot, Ben ^a   Russell, Nicola S ^a   Coppes, Rob P ^b   Stewart, Fiona A ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; IRRADIATION; MAMMALS;

ANTI-INFLAMMATORIES; BLOOD UREA NITROGENS; INFLAMMATORY CELLS; INFLAMMATORY RESPONSE; LATE SIDE EFFECTS; METHODS AND MATERIALS; NORMAL TISSUE DAMAGE; VASCULAR STRUCTURES;

RADIATION;

FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MERTIATIDE TC 99M; THALIDOMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL INJURY; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HEMATOCRIT; HISTOLOGY; INFLAMMATION; IONIZING RADIATION; IRRADIATION; KIDNEY; KIDNEY FUNCTION; KIDNEY TUBULE DAMAGE; MOUSE; NEPHROTOXICITY; NONHUMAN; PERICYTE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIATION NEPHROPATHY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; UREA NITROGEN BLOOD LEVEL;

ANGIOGENESIS MODULATING AGENTS; ANIMALS; ANTI-INFLAMMATORY AGENTS; FEMALE; FIBROSIS; GENES, SIS; GLOMERULAR FILTRATION RATE; KIDNEY; KIDNEY TUBULES; MICE; MICE, INBRED C57BL; NEPHRITIS; RADIATION INJURIES, EXPERIMENTAL; THALIDOMIDE;

EID: 84902079987     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2014.03.039     Document Type: Article

References (31)

1. E.P. Cohen, and M.E. Robbins Radiation nephropathy Semin Nephrol 23 2003 486 499
2. S.M. Bentzen Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology Nat Rev Cancer 6 2006 702 713
3. D. Schaue, and W.H. McBride Links between innate immunity and normal tissue radiobiology Radiat Res 173 2010 406 417
4. M.E. Franks, G.R. Macpherson, and W.D. Figg Thalidomide Lancet 363 2004 1802 1811
5. R.J. D'Amato, M.S. Loughnan, and E. Flynn et al. Thalidomide is an inhibitor of angiogenesis Proc Natl Acad Sci U S A 91 1994 4082 4085
6. T. Ito, H. Ando, and H. Handa Teratogenic effects of thalidomide: Molecular mechanisms Cell Mol Life Sci 68 2011 1569 1579
7. C. Therapontos, L. Erskine, and E.R. Gardner et al. Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation Proc Natl Acad Sci U S A 106 2009 8573 8578
8. F. Lebrin, S. Srun, and K. Raymond et al. Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia Nat Med 16 2010 420 428
9. M. Melchert, and A. List The thalidomide saga Int J Biochem Cell Biol 39 2007 1489 1499
10. H. Arai, A. Furusu, and T. Nishino et al. Thalidomide prevents the progression of peritoneal fibrosis in mice Acta Histochem Cytochem 44 2011 51 60
11. J.Y. Choe, H.J. Jung, and K.Y. Park et al. Anti-fibrotic effect of thalidomide through inhibiting TGF-beta-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice Inflamm Res 59 2010 177 188
12. S. Mondello, E. Mazzon, and R. Di Paola et al. Thalidomide suppresses sclerosing encapsulating peritonitis in a rat experimental model Shock 32 2009 332 339
13. C. Tabata, R. Tabata, and Y. Kadokawa et al. Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice J Immunol 179 2007 708 714
14. A. Yndestad, L.E. Vinge, and R. Bjornerheim et al. Thalidomide attenuates the development of fibrosis during post-infarction myocardial remodelling in rats Eur J Heart Fail 8 2006 790 796
15. S.W. Lee, Y.B. Park, and J. Yang et al. Attenuation of nephritis in lupus-prone mice by thalidomide Rheumatology (Oxford) 51 2012 2131 2140
16. A.C. Santana, S. Degaspari, and S. Catanozi et al. Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice Nephrol Dial Transplant 28 2013 1140 1149
17. M Scharpfenecker, B Floot, and NS Russell et al. Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys Radiother Oncol 92 2009 484 491
18. M Scharpfenecker, B Floot, and NS Russell et al. The TGF-beta co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney Radiother Oncol 105 2012 313 320
19. M Scharpfenecker, B Floot, and NS Russell et al. Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice Radiother Oncol 108 2013 464 468
20. D. Ribatti, B. Nico, and E. Crivellato The role of pericytes in angiogenesis Int J Dev Biol 55 2011 261 268
21. H.P. Rodemann, and M.A. Blaese Responses of normal cells to ionizing radiation Semin Radiat Oncol 17 2007 81 88
22. S.B. Lee, and R. Kalluri Mechanistic connection between inflammation and fibrosis Kidney Int Suppl 2010 S22 S26
23. C.B. Westbury, and J.R. Yarnold Radiation fibrosis - current clinical and therapeutic perspectives Clin Oncol (R Coll Radiol) 24 2012 657 672
24. A.R. Chade Renovascular disease, microcirculation, and the progression of renal injury: Role of angiogenesis Am J Physiol Regul Integr Comp Physiol 300 2011 R783 R790
25. A. Armulik, G. Genove, and C. Betsholtz Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises Dev Cell 21 2011 193 215
26. S.L. Lin, T. Kisseleva, and D.A. Brenner et al. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney Am J Pathol 173 2008 1617 1627
27. Y.T. Chen, F.C. Chang, and C.F. Wu et al. Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis Kidney Int 80 2011 1170 1181
28. R.S. Al Lamki, J. Wang, and A.M. Tolkovsky et al. TL1A both promotes and protects from renal inflammation and injury J Am Soc Nephrol 19 2008 953 960
29. S. Majumdar, B. Lamothe, and B.B. Aggarwal Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester J Immunol 168 2002 2644 2651
30. N. Magne, R.A. Toillon, and V. Bottero et al. NF-kappaB modulation and ionizing radiation: Mechanisms and future directions for cancer treatment Cancer Lett 231 2006 158 168
31. A.R. Chade, J.D. Krier, and O. Galili et al. Role of renal cortical neovascularization in experimental hypercholesterolemia Hypertension 50 2007 729 736