-
1
-
-
79955884572
-
Primary neurosurgery for pediatric low-grade gliomas: A prospective multi-institutional study from the Children's Oncology Group
-
Discussion 1554-5
-
Wisoff JH et al. Primary neurosurgery for pediatric low-grade gliomas: a prospective multi-institutional study from the Children's Oncology Group. Neurosurgery. 2011;68(6):1548-54. Discussion 1554-5.
-
(2011)
Neurosurgery
, vol.68
, Issue.6
, pp. 1548-1554
-
-
Wisoff, J.H.1
-
2
-
-
34547122001
-
The 2007 WHO classification of tumours of the central nervous system
-
DOI 10.1007/s00401-007-0243-4
-
Louis DN et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114(2):97-109. (Pubitemid 47103521)
-
(2007)
Acta Neuropathologica
, vol.114
, Issue.2
, pp. 97-109
-
-
Louis, D.N.1
Ohgaki, H.2
Wiestler, O.D.3
Cavenee, W.K.4
Burger, P.C.5
Jouvet, A.6
Scheithauer, B.W.7
Kleihues, P.8
-
3
-
-
84875893063
-
Pathological and molecular advances in pediatric low-grade astrocytoma
-
Rodriguez FJ et al. Pathological and molecular advances in pediatric low-grade astrocytoma. Annu Rev Pathol. 2013;8:361-79.
-
(2013)
Annu Rev Pathol
, vol.8
, pp. 361-379
-
-
Rodriguez, F.J.1
-
4
-
-
84899678794
-
Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: An analysis of the Surveillance Epidemiology and End Results (SEER) database
-
A large study of of 4,040 children showed that pediatric LGGs are associated with excellent long term survival with low likelihood of pedaitric LGG related death in adult survivors thereby emphazising the need for treatment strategies that will minimize long term sequelae
-
Bandopadhayay P, et al. Long-term outcome of 4,040 children diagnosed with pediatric low-grade gliomas: an analysis of the Surveillance Epidemiology and End Results (SEER) database. Pediatr Blood Cancer. 2014;61(7):1173-9. A large study of of 4,040 children showed that pediatric LGGs are associated with excellent long term survival with low likelihood of pedaitric LGG related death in adult survivors thereby emphazising the need for treatment strategies that will minimize long term sequelae.
-
(2014)
Pediatr Blood Cancer
, vol.61
, Issue.7
, pp. 1173-1179
-
-
Bandopadhayay, P.1
-
5
-
-
84892493210
-
Children <1 year show an inferior outcome when treated according to the traditional LGG treatment strategy: A report from the German multicenter trial HIT-LGG 1996 for children with low grade glioma (LGG)
-
Mirow C et al. Children <1 year show an inferior outcome when treated according to the traditional LGG treatment strategy: a report from the German multicenter trial HIT-LGG 1996 for children with low grade glioma (LGG). Pediatr Blood Cancer. 2014;61(3):457-63.
-
(2014)
Pediatr Blood Cancer
, vol.61
, Issue.3
, pp. 457-463
-
-
Mirow, C.1
-
6
-
-
73149097929
-
Outcome and prognostic features in pediatric gliomas: A review of 6212 cases from the Surveillance, Epidemiology, and End Results database
-
Qaddoumi I, Sultan I, Gajjar A. Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the Surveillance, Epidemiology, and End Results database. Cancer. 2009;115(24):5761-70.
-
(2009)
Cancer
, vol.115
, Issue.24
, pp. 5761-5770
-
-
Qaddoumi, I.1
Sultan, I.2
Gajjar, A.3
-
7
-
-
84876135959
-
Prognostic factors and survival patterns in pediatric low-grade gliomas over 4 decades
-
Youland RS et al. Prognostic factors and survival patterns in pediatric low-grade gliomas over 4 decades. J Pediatr Hematol Oncol. 2013;35(3):197-205.
-
(2013)
J Pediatr Hematol Oncol
, vol.35
, Issue.3
, pp. 197-205
-
-
Youland, R.S.1
-
8
-
-
84879661588
-
Long-term outcome of centrally located low-grade glioma in children
-
Terashima K et al. Long-term outcome of centrally located low-grade glioma in children. Cancer. 2013;119(14):2630-8.
-
(2013)
Cancer
, vol.119
, Issue.14
, pp. 2630-2638
-
-
Terashima, K.1
-
9
-
-
45549101397
-
Outcome analysis of childhood low-grade astrocytomas
-
DOI 10.1002/pbc.21563
-
Fisher PG et al. Outcome analysis of childhood low-grade astrocytomas. Pediatr Blood Cancer. 2008;51(2):245-50. (Pubitemid 351874420)
-
(2008)
Pediatric Blood and Cancer
, vol.51
, Issue.2
, pp. 245-250
-
-
Fisher, P.G.1
Tihan, T.2
Goldthwaite, P.T.3
Wharam, M.D.4
Carson, B.S.5
Weingart, J.D.6
Repka, M.X.7
Cohen, K.J.8
Burger, P.C.9
-
10
-
-
84866923764
-
Long-term follow-up of the multicenter, multidisciplinary treatment study HIT-LGG-1996 for low-grade glioma in children and adolescents of the German Speaking Society of Pediatric Oncology and Hematology
-
Gnekow AK et al. Long-term follow-up of the multicenter, multidisciplinary treatment study HIT-LGG-1996 for low-grade glioma in children and adolescents of the German Speaking Society of Pediatric Oncology and Hematology. Neuro-Oncology. 2012;14(10):1265-84.
-
(2012)
Neuro-Oncology
, vol.14
, Issue.10
, pp. 1265-1284
-
-
Gnekow, A.K.1
-
11
-
-
0028933769
-
Low-grade gliomas of the cerebral hemispheres in children: An analysis of 71 cases
-
Pollack IF et al. Low-grade gliomas of the cerebral hemispheres in children: an analysis of 71 cases. J Neurosurg. 1995;82(4):536-47.
-
(1995)
J Neurosurg
, vol.82
, Issue.4
, pp. 536-547
-
-
Pollack, I.F.1
-
12
-
-
0030872762
-
Low-grade astrocytoma: A decade of experience at St. Jude Children's Research Hospital
-
Gajjar A et al. Low-grade astrocytoma: a decade of experience at St. Jude Children's Research Hospital. J Clin Oncol Off J Am Soc Clin Oncol. 1997;15(8):2792-9. (Pubitemid 27330005)
-
(1997)
Journal of Clinical Oncology
, vol.15
, Issue.8
, pp. 2792-2799
-
-
Gajjar, A.1
Sanford, R.A.2
Heideman, R.3
Jenkins, J.J.4
Walter, A.5
Li, Y.6
Langston, J.W.7
Muhlbauer, M.8
Boyett, J.M.9
Kun, L.E.10
-
13
-
-
84880824085
-
Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas
-
Steinbok P et al. Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg. 2013;29(8):1269-75.
-
(2013)
Childs Nerv Syst ChNS off J Int Soc Pediatr Neurosurg
, vol.29
, Issue.8
, pp. 1269-1275
-
-
Steinbok, P.1
-
14
-
-
33744466792
-
The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas
-
DOI 10.1215/15228517-2005-011
-
Mishra KK et al. The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas. Neuro-Oncology. 2006;8(2):166-74. (Pubitemid 46542661)
-
(2006)
Neuro-Oncology
, vol.8
, Issue.2
, pp. 166-174
-
-
Mishra, K.K.1
Puri, D.R.2
Missett, B.T.3
Lamborn, K.R.4
Prados, M.D.5
Berger, M.S.6
Banerjee, A.7
Gupta, N.8
Wara, W.M.9
Haas-Kogan, D.A.10
-
15
-
-
0035501207
-
Results of a policy of surveillance alone after surgical management of pediatric low grade gliomas
-
Fisher BJ et al. Results of a policy of surveillance alone after surgical management of pediatric low grade gliomas. Int J Radiat Oncol Biol Phys. 2001;51(3):704-10.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, Issue.3
, pp. 704-710
-
-
Fisher, B.J.1
-
16
-
-
68949102265
-
Phase II trial of conformal radiation therapy for pediatric low-grade glioma
-
Merchant TE et al. Phase II trial of conformal radiation therapy for pediatric low-grade glioma. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27(22):3598-604.
-
(2009)
J Clin Oncol off J Am Soc Clin Oncol
, vol.27
, Issue.22
, pp. 3598-3604
-
-
Merchant, T.E.1
-
17
-
-
79951823622
-
Survival and long-term health and cognitive outcomes after low-grade glioma
-
Armstrong GT et al. Survival and long-term health and cognitive outcomes after low-grade glioma. Neuro-Oncology. 2011;13(2):223-34.
-
(2011)
Neuro-Oncology
, vol.13
, Issue.2
, pp. 223-234
-
-
Armstrong, G.T.1
-
18
-
-
0032989713
-
Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma
-
DOI 10.1002/1531-8249(199903)45:3<393::AID-ANA17
-
Grill J et al. Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma. Ann Neurol. 1999;45(3):393-6. (Pubitemid 29120046)
-
(1999)
Annals of Neurology
, vol.45
, Issue.3
, pp. 393-396
-
-
Grill, J.1
Couanet, D.2
Cappelli, C.3
Habrand, J.L.4
Rodriguez, D.5
Sainte-Rose, C.6
Kalifa, C.7
-
19
-
-
0026765363
-
Vascular malformation with radiation vasculopathy after treatment of chiasmatic/hypothalamic glioma
-
Epstein MA et al. Vascular malformation with radiation vasculopathy after treatment of chiasmatic/hypothalamic glioma. Cancer. 1992;70(4):887-93.
-
(1992)
Cancer
, vol.70
, Issue.4
, pp. 887-893
-
-
Epstein, M.A.1
-
20
-
-
68949122986
-
Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: Prospective evaluation of cognitive, endocrine, and hearing deficits
-
Merchant TE et al. Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits. J Clin Oncol Off J Am Soc Clin Oncol. 2009;27(22):3691-7.
-
(2009)
J Clin Oncol off J Am Soc Clin Oncol
, vol.27
, Issue.22
, pp. 3691-3697
-
-
Merchant, T.E.1
-
21
-
-
80755126832
-
Stereotactic brachytherapy with iodine-125 seeds for the treatment of inoperable low-grade gliomas in children: Longterm outcome
-
Ruge MI et al. Stereotactic brachytherapy with iodine-125 seeds for the treatment of inoperable low-grade gliomas in children: longterm outcome. J Clin Oncol Off J Am Soc Clin Oncol. 2011;29(31):4151-9.
-
(2011)
J Clin Oncol off J Am Soc Clin Oncol
, vol.29
, Issue.31
, pp. 4151-4159
-
-
Ruge, M.I.1
-
22
-
-
1942519187
-
New Technologies in Radiation Therapy for Pediatric Brain Tumors: The Rationale for Proton Radiation Therapy
-
DOI 10.1002/pbc.10471
-
Kirsch DG, Tarbell NJ. New technologies in radiation therapy for pediatric brain tumors: the rationale for proton radiation therapy. Pediatr Blood Cancer. 2004;42(5):461-4. (Pubitemid 38524479)
-
(2004)
Pediatric Blood and Cancer
, vol.42
, Issue.5
, pp. 461-464
-
-
Kirsch, D.G.1
Tarbell, N.J.2
-
23
-
-
0031002713
-
Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas
-
Packer RJ et al. Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg. 1997;86(5):747-54. (Pubitemid 27187674)
-
(1997)
Journal of Neurosurgery
, vol.86
, Issue.5
, pp. 747-754
-
-
Packer, R.J.1
Ater, J.2
Allen, J.3
Phillips, P.4
Geyer, R.5
Nicholson, H.S.6
Jakacki, R.7
Kurczynski, E.8
Needle, M.9
Finlay, J.10
Reaman, G.11
Boyett, J.M.12
-
24
-
-
0027267434
-
Carboplatin and vincristine for recurrent and newly diagnosed low-grade gliomas of childhood
-
Packer RJ et al. Carboplatin and vincristine for recurrent and newly diagnosed low-grade gliomas of childhood. J Clin Oncol Off J Am Soc Clin Oncol. 1993;11(5):850-6. (Pubitemid 23146078)
-
(1993)
Journal of Clinical Oncology
, vol.11
, Issue.5
, pp. 850-856
-
-
Packer, R.J.1
Lange, B.2
Ater, J.3
Nicholson, H.S.4
Allen, J.5
Walker, R.6
Prados, M.7
Jakacki, R.8
Reaman, G.9
Needles, M.N.10
Phillips, P.C.11
Ryan, J.12
Boyett, J.M.13
Geyer, R.14
Finlay, J.15
-
25
-
-
0036644885
-
Phase II study of carboplatin in children with progressive low-grade gliomas
-
DOI 10.1200/JCO.2002.12.008
-
Gururangan S et al. Phase II study of carboplatin in children with progressive low-grade gliomas. J Clin Oncol Off J Am Soc Clin Oncol. 2002;20(13):2951-8. (Pubitemid 34728889)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.13
, pp. 2951-2958
-
-
Gururangan, S.1
Cavazos, C.M.2
Ashley, D.3
Herndon II, J.E.4
Bruggers, C.S.5
Moghrabi, A.6
Scarcella, D.L.7
Watral, M.8
Tourt-Uhlig, S.9
Reardon, D.10
Friedman, H.S.11
-
26
-
-
0037108821
-
High response rate to cisplatin/etoposide regimen in childhood low-grade glioma
-
DOI 10.1200/JCO.2002.08.087
-
Massimino M et al. High response rate to cisplatin/etoposide regimen in childhood low-grade glioma. J Clin Oncol Off J Am Soc Clin Oncol. 2002;20(20):4209-16. (Pubitemid 35191023)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.20
, pp. 4209-4216
-
-
Massimino, M.1
Spreafico, F.2
Cefalo, G.3
Riccardi, R.4
Tesoro-Tess, J.D.5
Gandola, L.6
Riva, D.7
Ruggiero, A.8
Valentini, L.9
Mazza, E.10
Genitori, L.11
Di, R.C.12
Navarria, P.13
Casanova, M.14
Ferrari, A.15
Luksch, R.16
Terenziani, M.17
Balestrini, M.R.18
Colosimo, C.19
Fossati-Bellani, F.20
more..
-
27
-
-
79952193946
-
A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma
-
Massimino M et al. A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma. J Neuro-Oncol. 2010;100(1):65-71.
-
(2010)
J Neuro-Oncol
, vol.100
, Issue.1
, pp. 65-71
-
-
Massimino, M.1
-
28
-
-
84866049462
-
Successful treatment with a low-dose cisplatin-etoposide regimen for patients with diencephalic syndrome
-
Sardi I et al. Successful treatment with a low-dose cisplatin-etoposide regimen for patients with diencephalic syndrome. J Neuro-Oncol. 2012;109(2):375-83.
-
(2012)
J Neuro-Oncol
, vol.109
, Issue.2
, pp. 375-383
-
-
Sardi, I.1
-
29
-
-
1542438631
-
Progression-free survival in children with optic pathway tumors: Dependence on age and the quality of the response to chemotherapy - Results of the first French prospective study for the French Society of Pediatric Oncology
-
DOI 10.1200/JCO.2003.03.043
-
Laithier V et al. Progression-free survival in children with optic pathway tumors: dependence on age and the quality of the response to chemotherapy-results of the first French prospective study for the French Society of Pediatric Oncology. J Clin Oncol Off J Am Soc Clin Oncol. 2003;21(24):4572-8. (Pubitemid 46594029)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.24
, pp. 4572-4578
-
-
Laithier, V.1
Grill, J.2
Le, D.M.-C.3
Ruchoux, M.-M.4
Couanet, D.5
Doz, F.6
Pichon, F.7
Rubie, H.8
Frappaz, D.9
Vannier, J.-P.10
Babin-Boilletot, A.11
Sariban, E.12
Chastagner, P.13
Zerah, M.14
Raquin, M.-A.15
Hartmann, O.16
Kalifa, C.17
-
31
-
-
79952187228
-
Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update
-
Mishra KK et al. Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update. J Neuro-Oncol. 2010;100(1):121-7.
-
(2010)
J Neuro-Oncol
, vol.100
, Issue.1
, pp. 121-127
-
-
Mishra, K.K.1
-
32
-
-
84860387906
-
Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma
-
This phase II study demonstrated that vinblastine can be considered as an alternative to radiotherapy in patients with recurrent LGGs that have failed first-line chemotherapy
-
Bouffet E et al. Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(12):1358-63. This phase II study demonstrated that vinblastine can be considered as an alternative to radiotherapy in patients with recurrent LGGs that have failed first-line chemotherapy.
-
(2012)
J Clin Oncol off J Am Soc Clin Oncol
, vol.30
, Issue.12
, pp. 1358-1363
-
-
Bouffet, E.1
-
33
-
-
80052717576
-
A phase 1 study of vinblastine in combination with carboplatin for children with low-grade gliomas: A Children's Oncology Group phase 1 consortium study
-
Jakacki RI et al. A phase 1 study of vinblastine in combination with carboplatin for children with low-grade gliomas: a Children's Oncology Group phase 1 consortium study. Neuro-Oncology. 2011;13(8):910-5.
-
(2011)
Neuro-Oncology
, vol.13
, Issue.8
, pp. 910-915
-
-
Jakacki, R.I.1
-
34
-
-
84860373449
-
Pediatric oncology: Vinblastine in low-grade glioma
-
Villanueva MT. Pediatric oncology: vinblastine in low-grade glioma. Nat Rev Clin Oncol. 2012;9(5):248.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, Issue.5
, pp. 248
-
-
Villanueva, M.T.1
-
36
-
-
34147192979
-
Temozolomide in children with progressive low-grade glioma
-
DOI 10.1215/15228517-2006-030
-
Gururangan S et al. Temozolomide in children with progressive low-grade glioma. Neuro-Oncology. 2007;9(2):161-8. (Pubitemid 46580317)
-
(2007)
Neuro-Oncology
, vol.9
, Issue.2
, pp. 161-168
-
-
Gururangan, S.1
Fisher, M.J.2
Allen, J.C.3
Herndon II, J.E.4
Quinn, J.A.5
Reardon, D.A.6
Vredenburgh, J.J.7
Desjardins, A.8
Phillips, P.C.9
Watral, M.A.10
Krauser, J.M.11
Friedman, A.H.12
Friedman, H.S.13
-
37
-
-
61449249107
-
Quality of life in low-grade glioma patients receiving temozolomide
-
Liu R et al. Quality of life in low-grade glioma patients receiving temozolomide. Neuro-Oncology. 2009;11(1):59-68.
-
(2009)
Neuro-Oncology
, vol.11
, Issue.1
, pp. 59-68
-
-
Liu, R.1
-
38
-
-
0029101377
-
Long-term outcome of hypothalamic/chiasmatic astrocytomas in children treated with conservative surgery
-
Sutton LN et al. Long-term outcome of hypothalamic/chiasmatic astrocytomas in children treated with conservative surgery. J Neurosurg. 1995;83(4):583-9.
-
(1995)
J Neurosurg
, vol.83
, Issue.4
, pp. 583-589
-
-
Sutton, L.N.1
-
39
-
-
84864036181
-
Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: A report from the Children's Oncology Group
-
This randomized controlled trial of the carboplatin/vincristine and thioguanine/procarbazine/lomustine and vincristine showed that both regimens are effective in the treatment of LGGs and the differences in the toxicity profiles may influence physician choice of treatment regimens
-
Ater JL et al. Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(21):2641-7. This randomized controlled trial of the carboplatin/vincristine and thioguanine/procarbazine/lomustine and vincristine showed that both regimens are effective in the treatment of LGGs and the differences in the toxicity profiles may influence physician choice of treatment regimens.
-
(2012)
J Clin Oncol off J Am Soc Clin Oncol
, vol.30
, Issue.21
, pp. 2641-2647
-
-
Ater, J.L.1
-
40
-
-
78349242122
-
Tumour vasculature and angiogenic profile of paediatric pilocytic astrocytoma; is it much different from glioblastoma?
-
Sie M et al. Tumour vasculature and angiogenic profile of paediatric pilocytic astrocytoma; is it much different from glioblastoma? Neuropathol Appl Neurobiol. 2010;36(7):636-47.
-
(2010)
Neuropathol Appl Neurobiol
, vol.36
, Issue.7
, pp. 636-647
-
-
Sie, M.1
-
41
-
-
66749085796
-
Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan
-
Packer RJ et al. Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan. Pediatr Blood Cancer. 2009;52(7):791-5.
-
(2009)
Pediatr Blood Cancer
, vol.52
, Issue.7
, pp. 791-795
-
-
Packer, R.J.1
-
42
-
-
84874957098
-
Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas
-
This study showed that antiangiogenic agents can be used in the treatment of LGGs with rapid clinical responses but however may not result in sustained stable disease
-
Hwang EI et al. Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas. Pediatr Blood Cancer. 2013;60(5):776-82. This study showed that antiangiogenic agents can be used in the treatment of LGGs with rapid clinical responses but however may not result in sustained stable disease.
-
(2013)
Pediatr Blood Cancer
, vol.60
, Issue.5
, pp. 776-782
-
-
Hwang, E.I.1
-
43
-
-
84893111710
-
Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas-a Pediatric Brain Tumor Consortium study
-
This phase II study showed that a combination of antiangiogenic agent bevacizumab and irinotecan can result in sustained disease control in some children with recurrent LGGs
-
Gururangan S et al. Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas-a Pediatric Brain Tumor Consortium study. Neuro-Oncology. 2014;16(2):310-7. This phase II study showed that a combination of antiangiogenic agent bevacizumab and irinotecan can result in sustained disease control in some children with recurrent LGGs.
-
(2014)
Neuro-Oncology
, vol.16
, Issue.2
, pp. 310-317
-
-
Gururangan, S.1
-
44
-
-
84892733049
-
Marked recovery of vision in children with optic pathway gliomas treated with bevacizumab
-
Avery RA et al. Marked recovery of vision in children with optic pathway gliomas treated with bevacizumab. JAMA Ophthalmol. 2014;132(1):111-4.
-
(2014)
JAMA Ophthalmol
, vol.132
, Issue.1
, pp. 111-114
-
-
Avery, R.A.1
-
45
-
-
84859545351
-
Biologically targeted therapeutics in pediatric brain tumors
-
Nageswara Rao AA et al. Biologically targeted therapeutics in pediatric brain tumors. Pediatr Neurol. 2012;46(4):203-11.
-
(2012)
Pediatr Neurol
, vol.46
, Issue.4
, pp. 203-211
-
-
Nageswara Rao, A.A.1
-
46
-
-
78649707335
-
Lenalidomide mode of action: Linking bench and clinical findings
-
Davies F, Baz R. Lenalidomide mode of action: linking bench and clinical findings. Blood Rev. 2010;24 Suppl 1:S13-9.
-
(2010)
Blood Rev
, vol.24
, Issue.SUPPL. 1
-
-
Davies, F.1
Baz, R.2
-
47
-
-
79951986245
-
Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018
-
Warren KE et al. Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018. J Clin Oncol Off J Am Soc Clin Oncol. 2011;29(3):324-9.
-
(2011)
J Clin Oncol off J Am Soc Clin Oncol
, vol.29
, Issue.3
, pp. 324-329
-
-
Warren, K.E.1
-
48
-
-
76549123056
-
Neurofibromatosis type 1 and tumorigenesis: Molecular mechanisms and therapeutic implications
-
Gottfried ON, Viskochil DH, Couldwell WT. Neurofibromatosis type 1 and tumorigenesis: molecular mechanisms and therapeutic implications. Neurosurg Focus. 2010;28(1):E8.
-
(2010)
Neurosurg Focus
, vol.28
, Issue.1
-
-
Gottfried, O.N.1
Viskochil, D.H.2
Couldwell, W.T.3
-
49
-
-
79960388615
-
BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma
-
Hawkins C et al. BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma. Clin Cancer Res Off J Am Assoc Cancer Res. 2011;17(14):4790-8.
-
(2011)
Clin Cancer Res off J Am Assoc Cancer Res
, vol.17
, Issue.14
, pp. 4790-4798
-
-
Hawkins, C.1
-
50
-
-
67349219657
-
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
-
Jones DT et al. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene. 2009;28(20):2119-23.
-
(2009)
Oncogene
, vol.28
, Issue.20
, pp. 2119-2123
-
-
Jones, D.T.1
-
51
-
-
79958087774
-
Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
-
Cin H et al. Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. Acta Neuropathol. 2011;121(6):763-74.
-
(2011)
Acta Neuropathol
, vol.121
, Issue.6
, pp. 763-774
-
-
Cin, H.1
-
52
-
-
78149467927
-
Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
-
Dougherty MJ et al. Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro-Oncology. 2010;12(7):621-30.
-
(2010)
Neuro-Oncology
, vol.12
, Issue.7
, pp. 621-630
-
-
Dougherty, M.J.1
-
53
-
-
34548726320
-
Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma
-
DOI 10.1055/s-2007-984451
-
Janzarik WG et al. Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma. Neuropediatrics. 2007;38(2):61-3. (Pubitemid 47434497)
-
(2007)
Neuropediatrics
, vol.38
, Issue.2
, pp. 61-63
-
-
Janzarik, W.G.1
Kratz, C.P.2
Loges, N.T.3
Olbrich, H.4
Klein, C.5
Schafer, T.6
Scheurlen, W.7
Roggendorf, W.8
Weiller, C.9
Niemeyer, C.10
Korinthenberg, R.11
Pfister, S.12
Omran, H.13
-
54
-
-
80054044954
-
Vemurafenib in melanoma with BRAF V600E mutation
-
Author reply 1450
-
Morita H, Nagai R. Vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;365(15):1448. Author reply 1450.
-
(2011)
N Engl J Med
, vol.365
, Issue.15
, pp. 1448
-
-
Morita, H.1
Nagai, R.2
-
55
-
-
78649473910
-
The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients
-
Farina-Sarasqueta A et al. The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol Off J Eur Soc Med Oncol ESMO. 2010;21(12):2396-402.
-
(2010)
Ann Oncol off J Eur Soc Med Oncol ESMO
, vol.21
, Issue.12
, pp. 2396-2402
-
-
Farina-Sarasqueta, A.1
-
56
-
-
79954441895
-
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
-
This large study demonstrated the high frequency of BRAF V600E mutations in different LGGs, thereby opening up the possibility of using targeted therapy in BRAF V600E mutated tumors
-
Schindler G et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011;121(3):397-405. This large study demonstrated the high frequency of BRAF V600E mutations in different LGGs, thereby opening up the possibility of using targeted therapy in BRAF V600E mutated tumors.
-
(2011)
Acta Neuropathol
, vol.121
, Issue.3
, pp. 397-405
-
-
Schindler, G.1
-
57
-
-
84862193195
-
Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas
-
Horbinski C et al. Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas. Neuro-Oncology. 2012;14(6):777-89.
-
(2012)
Neuro-Oncology
, vol.14
, Issue.6
, pp. 777-789
-
-
Horbinski, C.1
-
58
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507-16.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
-
59
-
-
84868120907
-
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, open-label, phase 2 trial
-
Long GV et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol. 2012;13(11):1087-95.
-
(2012)
Lancet Oncol
, vol.13
, Issue.11
, pp. 1087-1095
-
-
Long, G.V.1
-
60
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012;380(9839):358-65.
-
(2012)
Lancet
, vol.380
, Issue.9839
, pp. 358-365
-
-
Hauschild, A.1
-
61
-
-
84873378603
-
Neoadjuvant treatment of a solitary melanoma brain metastasis with vemurafenib
-
Kolar GR et al. Neoadjuvant treatment of a solitary melanoma brain metastasis with vemurafenib. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31(3):e40-3.
-
(2013)
J Clin Oncol off J Am Soc Clin Oncol
, vol.31
, Issue.3
-
-
Kolar, G.R.1
-
62
-
-
84896714827
-
Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, openlabel study
-
McArthur GA et al. Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, openlabel study. Lancet Oncol. 2014;15(3):323-32.
-
(2014)
Lancet Oncol
, vol.15
, Issue.3
, pp. 323-332
-
-
McArthur, G.A.1
-
63
-
-
84921881584
-
Vemurafenib-induced neutrophilic panniculitis in a child with a brainstem glioma
-
doi:10.1111/pde.12316
-
West ES, Williams VL, Morelli JG. Vemurafenib-induced neutrophilic panniculitis in a child with a brainstem glioma. Pediatr Dermatol. 2014. doi:10.1111/pde.12316.
-
(2014)
Pediatr Dermatol
-
-
West, E.S.1
Williams, V.L.2
Morelli, J.G.3
-
64
-
-
77949685981
-
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
-
Hatzivassiliou G et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature. 2010;464(7287):431-5.
-
(2010)
Nature
, vol.464
, Issue.7287
, pp. 431-435
-
-
Hatzivassiliou, G.1
-
65
-
-
74849109743
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
Heidorn SJ et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell. 2010;140(2):209-21.
-
(2010)
Cell
, vol.140
, Issue.2
, pp. 209-221
-
-
Heidorn, S.J.1
-
66
-
-
84876040346
-
Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas
-
Sievert AJ et al. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proc Natl Acad Sci U S A. 2013;110(15):5957-62.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.15
, pp. 5957-5962
-
-
Sievert, A.J.1
-
67
-
-
84878952144
-
Phase II study of sorafenib in children with recurrent/progressive low-grade astrocytomas
-
This phase II study showed that sorefanib may be associated with tumor progression through paradoxical ERK activation
-
Karajannis MA, Fisher MJ, Milla SS, Cohen KJ, Legault G, Wisoff JH, et al. Phase II study of sorafenib in children with recurrent/progressive low-grade astrocytomas. Neuro-Oncology. 2012; 14(supplement 6). This phase II study showed that sorefanib may be associated with tumor progression through paradoxical ERK activation.
-
(2012)
Neuro-Oncology
, vol.14
, Issue.SUPPL. 6
-
-
Karajannis, M.A.1
Fisher, M.J.2
Milla, S.S.3
Cohen, K.J.4
Legault, G.5
Wisoff, J.H.6
-
68
-
-
84869067183
-
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas
-
Lito P et al. Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas. Cancer Cell. 2012;22(5):668-82.
-
(2012)
Cancer Cell
, vol.22
, Issue.5
, pp. 668-682
-
-
Lito, P.1
-
69
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos PI et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011;480(7377):387-90.
-
(2011)
Nature
, vol.480
, Issue.7377
, pp. 387-390
-
-
Poulikakos, P.I.1
-
70
-
-
84890804300
-
BRAF V600E mutation is associated with mTOR signaling activation in glioneuronal tumors
-
Prabowo AS et al. BRAF V600E mutation is associated with mTOR signaling activation in glioneuronal tumors. Brain Pathol. 2014;24(1):52-66.
-
(2014)
Brain Pathol
, vol.24
, Issue.1
, pp. 52-66
-
-
Prabowo, A.S.1
-
71
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature. 2012;483(7387):100-3.
-
(2012)
Nature
, vol.483
, Issue.7387
, pp. 100-103
-
-
Prahallad, A.1
-
73
-
-
77957071661
-
Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program
-
Kolb EA et al. Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer. 2010;55(4):668-77.
-
(2010)
Pediatr Blood Cancer
, vol.55
, Issue.4
, pp. 668-677
-
-
Kolb, E.A.1
-
74
-
-
84890644513
-
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma
-
Bid HK et al. Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma. Clin Cancer Res Off J Am Assoc Cancer Res. 2013;19(24):6716-29.
-
(2013)
Clin Cancer Res off J Am Assoc Cancer Res
, vol.19
, Issue.24
, pp. 6716-6729
-
-
Bid, H.K.1
-
75
-
-
0038540963
-
United at last: The tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling
-
DOI 10.1042/BST0310573
-
Manning BD, Cantley LC. United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans. 2003;31(Pt 3):573-8. (Pubitemid 36750733)
-
(2003)
Biochemical Society Transactions
, vol.31
, Issue.3
, pp. 573-578
-
-
Manning, B.D.1
Cantley, L.C.2
-
77
-
-
79955081038
-
Phenotypic variations in NF1-associated low grade astrocytomas: Possible role for increased mTOR activation in a subset
-
Jentoft M et al. Phenotypic variations in NF1-associated low grade astrocytomas: possible role for increased mTOR activation in a subset. Int J Clin Exp Pathol. 2010;4(1):43-57.
-
(2010)
Int J Clin Exp Pathol
, vol.4
, Issue.1
, pp. 43-57
-
-
Jentoft, M.1
-
78
-
-
84893202143
-
MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1
-
doi:10.1038/onc.2013.506
-
Brundage ME et al. MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1. Oncogene. 2014. doi:10.1038/onc.2013.506.
-
(2014)
Oncogene
-
-
Brundage, M.E.1
-
79
-
-
84870506967
-
Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner
-
Kaul A et al. Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner. Genes Dev. 2012;26(23):2561-6.
-
(2012)
Genes Dev
, vol.26
, Issue.23
, pp. 2561-2566
-
-
Kaul, A.1
-
80
-
-
84891878316
-
Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target
-
Hutt-Cabezas M et al. Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro-Oncology. 2013;15(12):1604-14.
-
(2013)
Neuro-Oncology
, vol.15
, Issue.12
, pp. 1604-1614
-
-
Hutt-Cabezas, M.1
-
81
-
-
33644827461
-
Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
-
DOI 10.1002/ana.20784
-
Franz DN et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol. 2006;59(3):490-8. (Pubitemid 43358069)
-
(2006)
Annals of Neurology
, vol.59
, Issue.3
, pp. 490-498
-
-
Franz, D.N.1
Leonard, J.2
Tudor, C.3
Chuck, G.4
Care, M.5
Sethuraman, G.6
Dinopoulos, A.7
Thomas, G.8
Crone, K.R.9
-
82
-
-
84885225587
-
Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex
-
Franz DN. Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex. Biologics Targets Ther. 2013;7:211-21.
-
(2013)
Biologics Targets Ther
, vol.7
, pp. 211-221
-
-
Franz, D.N.1
-
83
-
-
84873653141
-
Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma
-
This study showed that everolimus is safe and effective in the treatment of SEGAs in patients 3 years and older with TS
-
Krueger DA et al. Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma. Neurology. 2013;80(6):574-80. This study showed that everolimus is safe and effective in the treatment of SEGAs in patients 3 years and older with TS.
-
(2013)
Neurology
, vol.80
, Issue.6
, pp. 574-580
-
-
Krueger, D.A.1
-
84
-
-
84872088946
-
Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): A multicentre, randomised, placebo-controlled phase 3 trial
-
Franz DN et al. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet. 2013;381(9861):125-32.
-
(2013)
Lancet
, vol.381
, Issue.9861
, pp. 125-132
-
-
Franz, D.N.1
-
85
-
-
84897419670
-
A prospective multi-institutional phase II study of everolimus (RAD001), a mTOR inhibitor, in pediatric patients with recurrent or progressive low-grade gliomas. A POETIC consortium trial
-
This study showed that everolimus is well-tolerated and maybe effective in the treatment of pediatric recurrent LGGs
-
Kieran M, Yao X, Macy M, Geyer R, Cohen K, MacDonald T, et al. A prospective multi-institutional phase II study of everolimus (RAD001), a mTOR inhibitor, in pediatric patients with recurrent or progressive low-grade gliomas. A POETIC consortium trial. Pediatr Blood Cancer. 2013;60(S3):19. This study showed that everolimus is well-tolerated and maybe effective in the treatment of pediatric recurrent LGGs.
-
(2013)
Pediatr Blood Cancer
, vol.60
, Issue.S3
, pp. 19
-
-
Kieran, M.1
Yao, X.2
Macy, M.3
Geyer, R.4
Cohen, K.5
MacDonald, T.6
-
86
-
-
84870188356
-
A feasibility and efficacy study of rapamycin and erlotinib for recurrent pediatric low-grade glioma (LGG)
-
Yalon M et al. A feasibility and efficacy study of rapamycin and erlotinib for recurrent pediatric low-grade glioma (LGG). Pediatr Blood Cancer. 2013;60(1):71-6.
-
(2013)
Pediatr Blood Cancer
, vol.60
, Issue.1
, pp. 71-76
-
-
Yalon, M.1
-
87
-
-
68649118150
-
Clinical experience with nimotuzumab in cuban pediatric patients with brain tumors, 2005 to 2007
-
Saurez G et al. Clinical experience with nimotuzumab in cuban pediatric patients with brain tumors, 2005 to 2007. MEDICC Rev. 2009;11(3):27-33.
-
(2009)
MEDICC Rev
, vol.11
, Issue.3
, pp. 27-33
-
-
Saurez, G.1
-
88
-
-
84878723078
-
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
-
Whole-genome sequencing has helped identify multiple genomic alterations in 151 pediatric LGGs and potential therapeutic targets
-
Zhang J et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet. 2013;45(6):602-12. Whole-genome sequencing has helped identify multiple genomic alterations in 151 pediatric LGGs and potential therapeutic targets.
-
(2013)
Nat Genet
, vol.45
, Issue.6
, pp. 602-612
-
-
Zhang, J.1
|