Development of novel solid dispersion of tranilast using amphiphilic block copolymer for improved oral bioavailability

International Journal of Pharmaceutics

Volumn 452, Issue 1-2, 2013, Pages 220-226

  Onoue, Satomi ^a   Kojo, Yoshiki ^a   Suzuki, Hiroki ^a   Yuminoki, Kayo ^b   Kou, Keitatsu ^c   Kawabata, Yohei ^a,d   Yamauchi, Yukinori ^e   Hashimoto, Naofumi ^b   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^e MATSUYAMA UNIVERSITY   (Japan)

Author keywords

Bioavailability; Crystallinity; Dissolution; Solid dispersion; Tranilast

Indexed keywords

COPOLYMER; TRANILAST;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; ELECTROSPRAY MASS SPECTROMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WETTABILITY; X RAY POWDER DIFFRACTION;

EID: 84884210322     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.05.022     Document Type: Article

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