Galactosyl prodrug of palmitoylethanolamide: Synthesis, stability, cell permeation and cytoprotective activity

European Journal of Pharmaceutical Sciences

Volumn 62, Issue , 2014, Pages 33-39

  Luongo, Elvira ^a   Russo, Roberto ^a   Avagliano, Carmen ^a   Santoro, Anna ^a   Melisi, Daniela ^a   Orefice, Nicola Salvatore ^a   Raso, Giuseppina Mattace ^a   Meli, Rosaria ^a   Magliocca, Salvatore ^b   Nieddu, Maria ^b   Santiago, Gilvandete Maria Pinheiro ^c   Boatto, Gianpiero ^b   Calignano, Antonio ^a   Rimoli, Maria Grazia ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Cell culture; Cytoprotection; Liquid chromatography; N Palmitoylethanolamide; Permeability; Prodrugs

Indexed keywords

1,2,3,4 DIISOPROPYLIDENE 6 O SUCCINATE DEXTRO GALACTOPYRANOSIDE; DIACETONE 6' O PALMITOYLETHANOLAMIDE SUCCINAMYL DEXTRO GALACTOPYRANOSIDE; GALACTOSE; N PALMITOYLETHANOLAMIDE; PALMIDROL; PALMITOYLETHANOLAMIDE SUCCINAMYL DEXTRO GALACTOS 6' YL ESTER; PRODRUG; UNCLASSIFIED DRUG; ANALGESIC AGENT; ETHANOLAMINE DERIVATIVE; NEUROPROTECTIVE AGENT; NITRITE; OXIDOPAMINE; PALMITIC ACID DERIVATIVE; PALMITOYLETHANOLAMIDE-SUCCINAMYLGALACTOS-6′-YL ESTER;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; GLIOMA CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEUROBLASTOMA; NEUROLOGIC DISEASE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; PERMEABILITY; PH; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANALGESICS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL SURVIVAL; CYTOPROTECTION; DRUG STABILITY; ETHANOLAMINES; GALACTOSE; HUMANS; HYDROGEN-ION CONCENTRATION; NEUROPROTECTIVE AGENTS; NITRITES; OXIDOPAMINE; PALMITATES; PALMITIC ACIDS; PERMEABILITY; PRODRUGS;

EID: 84901989653     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.05.009     Document Type: Article

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