Galactosyl derivatives of L-arginine and D-arginine: Synthesis, stability, cell permeation, and nitric oxide production in pituitary GH3 cells

Journal of Medicinal Chemistry

Volumn 49, Issue 16, 2006, Pages 4826-4833

  Melisi, Daniela ^b   Secondo, Agnese ^a   Montoro, Paola ^c   Piacente, Sonia ^c   Rimoli, Maria Grazia ^b   Minale, Massimiliano ^a   De Caprariis, Paolo ^c   Annunziato, Lucio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE DERIVATIVE; ARGININE DEXTRO GALACTOS 6' YL ESTER; CITRULLINE; DEXTRO ARGININE; DEXTRO ARGININE DEXTRO GALACTOS 6' YL ESTER; GALACTOSE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CELL MEMBRANE PERMEABILITY; CELL STRAIN GH3; CONTROLLED STUDY; DOSE RESPONSE; DRUG PENETRATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENDOTHELIUM CELL; ENZYME SUBSTRATE; ESTERIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TIME; NONHUMAN;

ANIMALS; ARGININE; CATTLE; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GALACTOSE; NITRIC OXIDE; NITRITES; PITUITARY GLAND; PRODRUGS; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746896200     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060005s     Document Type: Article

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