Human papillomavirus clearance among males is associated with HIV acquisition and increased dendritic cell density in the foreskin

Journal of Infectious Diseases

Volumn 207, Issue 11, 2013, Pages 1713-1722

  Tobian, Aaron A R ^a,e   Grabowski, Mary K ^c   Kigozi, Godfrey ^e   Redd, Andrew D ^d   Eaton, Kevin P ^b   Serwadda, David ^e,f   Cornish, Toby C ^a   Nalugoda, Fred ^e   Watya, Stephen ^g   Buwembo, Denis ^e   Nkale, James ^e   Wawer, Maria J ^c,e   Quinn, Thomas C ^b,d   Gray, Ronald H ^c,e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e RAKAI HEALTH SCIENCES PROGRAM   (Uganda)

^f School of Public Health   (United States)

^g MAKERERE UNIVERSITY   (Uganda)

Author keywords

AIDS; cervical cancer; HIV; human papillomavirus (HPV); male circumcision; penile cancer; sexually transmitted infections; Uganda

Indexed keywords

T6 ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CASE CONTROL STUDY; CELL DENSITY; CELLULAR IMMUNITY; CIRCUMCISION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE ASSOCIATION; EPIDERMIS; GENOTYPE; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PREPUCE; PRIORITY JOURNAL; SEROCONVERSION; SEXUAL BEHAVIOR; VIRAL CLEARANCE; WART VIRUS;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; FORESKIN; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; YOUNG ADULT;

EID: 84877303672     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit035     Document Type: Article

References (38)

1. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet 2007; 370: 890-907.
2. Partridge JM, Koutsky LA. Genital human papillomavirus infection in men. Lancet Infect Dis 2006; 6:21-31.
3. Strickler HD, Burk RD, Fazzari M, et al. Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst 2005; 97:577-86.
4. Averbach SH, Gravitt PE, Nowak RG, et al. The association between cervical HPV infection and HIV acquisition among women in Zimbabwe. AIDS 2010; 24:1035-42.
5. Auvert B, Lissouba P, Cutler E, Zarca K, Puren A, Taljaard D. Association of oncogenic and nononcogenic human papillomavirus with HIV incidence. J Acquir Immune Defic Syndr 2010; 53:111-6.
6. Mbulawa ZZ, Coetzee D, Marais DJ, et al. Genital human papillomavirus prevalence and human papillomavirus concordance in heterosexual couples are positively associated with human immunodeficiency virus coinfection. J Infect Dis 2009; 199:1514-24.
7. Smith JS, Moses S, Hudgens MG, et al. Increased risk of HIV acquisition among Kenyan men with human papillomavirus infection. J Infect Dis 2010; 201:1677-85.
8. Smith-McCune KK, Shiboski S, Chirenje MZ, et al. Type-specific cervico-vaginal human papillomavirus infection increases risk of HIV acquisition independent of other sexually transmitted infections. PLoS One 2010; 5:e10094.
9. Tobian AA, Gray RH. Male foreskin and oncogenic human papillomavirus infection in men and their female partners. Future Microbiol 2011; 6:739-45.
10. Gray RH, Serwadda D, Kong X, et al. Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda. J Infect Dis 2010; 201:1455-62.
11. Serwadda D, Wawer MJ, Makumbi F, et al. Circumcision of HIVinfected men: effects on high-risk human papillomavirus infections in a randomized trial in Rakai, Uganda. J Infect Dis 2010; 201:1463-9.
12. Giuliano AR, Lee JH, Fulp W, et al. Incidence and clearance of genital human papillomavirus infection in men (HIM): a cohort study. Lancet 2011; 377:932-40.
13. Tobian AA, Kigozi G, Gravitt PE, et al. Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in Rakai, Uganda. AIDS 2012; 26:1555-65.
14. Coleman N, Birley HD, Renton AM, et al. Immunological events in regressing genital warts. Am J Clin Pathol 1994; 102:768-74.
15. Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet 2007; 369:657-66.
16. Tobian AA, Serwadda D, Quinn TC, et al. Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N Engl J Med 2009; 360:1298-309.
17. Tobian AA, Ssempijja V, Kigozi G, et al. Incident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda. AIDS 2009; 23:1589-94.
18. Tobian AA, Kong X, Wawer MJ, et al. Circumcision of HIV-infected men and transmission of human papillomavirus to female partners: analyses of data from a randomised trial in Rakai, Uganda. Lancet Infect Dis 2011; 11:604-12.
19. Gravitt PE, Peyton CL, Apple RJ, Wheeler CM. Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method. J Clin Microbiol 1998; 36:3020-7.
20. Tobian AAR, Charvat B, Ssempijja V, et al. Factors associated with the prevalence and incidence of herpes simplex virus type 2 infections among men in Rakai, Uganda. J Infect Dis 2009; 199:945-9.
21. Gamiel JL, Tobian AAR, Laeyendecker OB, et al. Improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in Rakai, Uganda. Clin Vaccine Immunol 2008; 15:888-90.
22. Johnson KE, Redd AD, Quinn TC, et al. Effects of HIV-1 and HSV-2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, Uganda. J Infect Dis 2011; 203:602-9.
23. Johnson KE, Sherman ME, Ssempiija V, et al. Foreskin inflammation is associated with HIV and herpes simplex virus type-2 infections in Rakai, Uganda. AIDS 2009; 23:1807-15.
24. Nowak RG, Gravitt P, Morrison CS, et al. Increases in human papillomavirus (HPV) detection during early HIV infection among women in Zimbabwe. J Infect Dis 2011; 203:1182-91.
25. Gravitt PE. The known unknowns of HPV natural history. J Clin Invest 2011; 121:4593-9.
26. Liang KY, Zeger S. Longitudinal data analysis using generalized linear models. Biometrika 1986; 73:13-22.
27. Cuzick J. AWilcoxon-type test for trend. Stat Med 1985; 4:87-90.
28. Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001; 357:1149-53.
29. Burchell AN, Coutlee F, Tellier PP, Hanley J, Franco EL. Genital transmission of human papillomavirus in recently formed heterosexual couples. J Infect Dis 2011; 204:1723-9.
30. Tobian AA, Gray RH. The medical benefits of male circumcision. JAMA 2011; 306:1479-80.
31. Wawer MJ, Tobian AA, Kigozi G, et al. Effect of circumcision of HIVnegative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda. Lancet 2011; 277:209-18.
32. Tobian AA, Gray RH, Quinn TC. Male circumcision for the prevention of acquisition and transmission of sexually transmitted infections: the case for neonatal circumcision. Arch Pediatr Adolesc Med 2010; 164:78-84.
33. Zhu J, Hladik F, Woodward A, et al. Persistence of HIV-1 receptorpositive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat Med 2009; 15:886-92.
34. McCoombe SG, Short RV. Potential HIV-1 target cells in the human penis. Aids 2006; 20:1491-5.
35. Felts RL, Narayan K, Estes JD, et al. 3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells. Proc Natl Acad Sci USA 2010; 107:13336-41.
36. Stanley M. Immune responses to human papillomavirus. Vaccine 2006; 24 (Suppl 1):S16-22.
37. Moscicki AB, Ellenberg JH, Farhat S, Xu J. Persistence of human papillomavirus infection in HIV-infected and-uninfected adolescent girls: risk factors and differences, by phylogenetic type. J Infect Dis 2004; 190: 37-45.
38. Ludewig B, Oehen S, Barchiesi F, Schwendener RA, Hengartner H, Zinkernagel RM. Protective antiviral cytotoxic T cell memory is most efficiently maintained by restimulation via dendritic cells. J Immunol 1999; 163:1839-44.