Differences in the gut microbiota of healthy children and those with type 1 diabetes

Pediatrics International

Volumn 56, Issue 3, 2014, Pages 336-343

  Soyucen, Erdogan ^a   Gulcan, Aynur ^b   Aktuglu Zeybek, Ayse Cigdem ^c   Onal, Hasan ^d   Kiykim, Ertugrul ^c   Aydin, Ahmet ^c  

^a AKDENIZ UNIVERSITY   (Turkey)

^b DUMLUPINAR UNIVERSITY   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

^d Children Education Hospital   (Turkey)

Author keywords

autoimmune disease; Candida albicans; gut flora; gut microbiota; type 1 diabetes mellitus

Indexed keywords

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTEROIDES; BIFIDOBACTERIUM; CANDIDA ALBICANS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENTEROBACTERIACEAE; ENTEROCOCCUS; ESCHERICHIA COLI; FECES ANALYSIS; FECES MICROFLORA; FEMALE; FUNGUS GROWTH; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE FLORA; LACTOBACILLUS; MALE; PRIORITY JOURNAL; INTESTINE; ISOLATION AND PURIFICATION; MICROBIOLOGY;

BIFIDOBACTERIUM; CANDIDA ALBICANS; CHILD; DIABETES MELLITUS, TYPE 1; ENTEROBACTERIACEAE; FEMALE; HUMANS; INTESTINES; MALE;

EID: 84901935805     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/ped.12243     Document Type: Article

References (37)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011; 34: 62-69.
2. Soyucen E, Yilmaz S, Celtik C, et al. Seroprevalence of autoimmune thyroiditis and celiac disease in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey. Turk. J. Gastroenterol. 2010; 21: 231-235.
3. Bodansky HJ, Staines A, Stephenson C, Haigh D, Cartwright R,. Evidence for an environmental effect in the etiology of insulin dependent diabetes in a transmigratory population. BMJ 1992; 304: 1020-1022.
4. Vaarala O, Atkinson MA, Neu J,. The "perfect storm" for type 1 diabetes: The complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes 2008; 57: 2555-2562.
5. Sapone A, De Magistris L, Pietzak M, et al. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes 2006; 55: 1443-1449.
6. Bosi E, Molteni L, Radaelli MG, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 2006; 49: 2824-2827.
7. Westerholm-Ormio M, Vaarala O, Pihkala P, et al. Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes. Diabetes 2003; 52: 2287-2295.
8. Auricchio R, Paparo F, Maglio M, et al. In vitro-deranged intestinal immune response to gliadin in type 1 diabetes. Diabetes 2004; 53: 1680-1683.
9. Neu J, Reverte CM, Mackey AD, et al. Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes. J. Pediatr. Gastroenterol. Nutr. 2005; 40: 589-595.
10. Rook GA, Brunet LR,. Microbes, immunoregulation, and the gut. Gut 2005; 54: 317-320.
11. Yan F, Polk DB,. Commensal bacteria in the gut: Learning who our friends are. Curr. Opin. Gastroenterol. 2004; 20: 565-571.
12. Cani PD, Bibiloni R, Knauf C, et al. Gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008; 57: 1470-1480.
13. Moro G, Aslanoglu S, Stahl B, et al. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch. Dis. Child. 2006; 91: 814-819.
14. Beckman G, Rüffer A,. Mikroökologie Des Darmes: Grundlagen, Diagnostik, Therapie. Schlüttersche, Hannover, 2000 (in German).
15. Shimizu K, Ogura H, Hamasaki T, et al. Altered gut flora are associated with septic complications and death in critically ill patients with systemic inflammatory response syndrome. Dig. Dis. Sci. 2011; 56: 1171-1177.
16. Vaarala O,. Is the origin of type 1 diabetes in the gut. Immunol. Cell Biol. 2012; 90: 271-276.
17. Todar K,. Lactic acid bacteria. Todar's Online Textbook of Bacteriology 2012; 1-5. Available from URL: http://textbookofbacteriology.net/lactics.html.
18. Strachan DP,. Hay fever, hygiene, and household size. BMJ 1989; 299: 259-260.
19. de Goffau MC, Luopajarvi K, Knip M, et al. Fecal microbiota composition differs between children with β-cell autoimmunity and those without. Diabetes 2013; 62: 1238-1244.
20. Brown CT, Davis-Richardson AG, Giongo A, et al. Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS ONE 2011; 10: e25792.
21. Kandemir N, Açikgöz E, Yordan N, et al. The epidemiology of juvenile-onset insulin-dependent diabetes mellitus in Turkish children: A retrospective analysis of 477 cases. Turk. J. Pediatr. 1994; 36: 191-195.
22. Vaarala O,. Gut microbiota and type 1 diabetes. Rev. Diabet. Stud. 2012; 9: 251-259.
23. Akesen E, Turan S, Güran T, et al. Prevalence of type 1 diabetes mellitus in 6-18-yr-old school children living in Istanbul, Turkey. Pediatr. Diabetes 2011; 12: 567-571.
24. Macie RI, Sghir A, Gaskins HR,. Developmental microbial ecology of the neonatal gastrointestinal tract. Am. J. Clin. Nutr. 1999; 69: 1035-1045.
25. Murray PR,. Manual of Clinical Microbiology, 7th edn. American Society for Microbiology, Washington DC, 1999.
26. Ryan KJ, Ray CG,. Sherris Medical Microbiology. Enterobacteriaceae, 5th edn. McGraw-Hill, New York, 2010.
27. Ewing WN,. The Living Gut, 2nd edn. Notthingam University Press, Nottingham, UK, 2008.
28. Schwiertz A, Gruhl B, Lobnitz M, et al. Development of the intestinal bacterial composition in hospitalized preterm infants in comparison with breast-fed, full term infants. Pediatr. Res. 2003; 54: 393-399.
29. Alderberth I, Lindberg E, Aberg N, et al. Reduced enterobacterial and increased staphylococcal colonization of the infantile bowel: An effect of hygienic lifestyle. Pediatr. Res. 2006; 59: 96-101.
30. Dahliquist G, Kallen B,. Maternal-child blood group incompatibility and other perinatal events increase the risk for early onset type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1992; 35: 671-675.
31. Ahadi M, Tabatabaeiyan M, Mozzami K,. Association between environmental factors and risk of type 1 diabetes-A case-control study. Endokrynol. Pol. 2011; 62: 134-137.
32. Patteson CC, Waugh NR, Carson DJ, Cole SK, Hadden DR,. A case-control investigation of perinatal risk factors for childhood type 1 diabetes in Northern Ireland and Scotland. Diabetes Care 1994; 17: 376-381.
33. Dahlquist GG, Patterson C, Soltesz G,. Perinatal risk factors for childhood type 1 diabetes in Europe. Diabetes Care 1999; 20: 1698-1702.
34. Mazmanian SK, Liu CH, Tzianabos AO, et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005; 122: 107-118.
35. Bernhardt H, Wellmer A, Zimmerman K, Knoke M,. Growth of Candida albicans in normal and altered faecal flora in the model of continuous flow culture. Mycoses 1995; 38: 265-270.
36. Sonoyama K, Miki A, Sugita R, et al. Gut colonization by Candida albicans aggravates inflammation in the gut and extra-gut tissues in mice. Med. Mycol. 2011; 49: 237-247.
37. Hooper LV, Wong MH, Thelin A, et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001; 291: 881-884.