Quaternary ammonium salt of U50488H, a new κ-opioid receptor agonist, protects rat heart against ischemia/reperfusion injury

European Journal of Pharmacology

Volumn 737, Issue , 2014, Pages 177-184

  Wang, Qianmei ^a,b   Sun, Yang ^a   Li, Juan ^b   Xing, Wenjuan ^b   Zhang, Shumiao ^b   Gu, Xiaoming ^b   Feng, Na ^b   Zhao, Lei ^b   Fan, Rong ^b   Wang, Yuemin ^b   Yin, Wen ^a   Pei, Jianming ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Ischemia reperfusion (I R) injury; Myocardial infarction; Quaternary ammonium of U50488H (Q U50488H); opioid receptor

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FREE RADICAL; KAPPA OPIATE RECEPTOR AGONIST; LACTATE DEHYDROGENASE; Q U50488H; QUATERNARY AMMONIUM DERIVATIVE; U50488H; UNCLASSIFIED DRUG; CARDIOTONIC AGENT; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; KAPPA OPIATE RECEPTOR; MALONALDEHYDE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD BRAIN BARRIER; BRAIN TISSUE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SOLUBILITY; AGONISTS; ANIMAL; BLOOD; BRAIN; CHEMISTRY; COMPLICATION; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; HEART; HEART MUSCLE; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; SPRAGUE DAWLEY RAT;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; APOPTOSIS; BRAIN; CARDIOTONIC AGENTS; GENE EXPRESSION REGULATION; HEART; MALE; MALONDIALDEHYDE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; POTASSIUM CHANNELS, INWARDLY RECTIFYING; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA;

EID: 84901885708     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.05.006     Document Type: Article

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