Effect of heparin on antigen-induced airway responses and pulmonary leukocyte accumulation in neonatally immunized rabbits

British Journal of Pharmacology

Volumn 129, Issue 8, 2000, Pages 1585-1596

  Preuss, Janet M H ^a,c   Page, Clive P ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Sackler Inst of Pulmon P   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Airway hyperresponsivenss; Antigen; Glycosaminoglycans; Heparin; Inflammation

Indexed keywords

ANTICOAGULANT AGENT; ANTIGEN; DALTEPARIN; HEPARIN; HISTAMINE; LOW MOLECULAR WEIGHT HEPARIN; POLYGLUTAMIC ACID;

AIRWAY RESISTANCE; ALTERNARIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL COUNT; CONCENTRATION RESPONSE; CONTROLLED STUDY; EOSINOPHIL; LEUKOCYTE AGGREGATION; LUNG; LUNG COMPLIANCE; LUNG FUNCTION; LUNG LAVAGE; NEUTROPHIL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RABBIT;

EID: 0033998799     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703247     Document Type: Article

References (41)

1. AHMED, T., ABRAHAM, W.M. & D'BROT, J. (1992). Effects of inhaled heparin on immunologic and nonimmunologic bronchoconstrictor responses in sheep. Am. Rev. Respir. Dis., 145, 566-570.
2. AHMED, T., GARRIGO, J. & DANTA, I. (1993a). Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N. Engl. J. Med., 329, 90-95.
3. AHMED, T., SYRISTE, T., LUCIO, J., ABRAHAM, W., ROBINSON, M. & D'BROT, J. (1993b). Inhibition of antigen-induced airway and cutaneous responses by heparin: a pharmacodynamic study. J. Appl. Physiol., 74, 1492-1498.
4. 3-mediated mast cell degranulation? J. Appl. Physiol., 76, 893-901.
5. BLOOM, G.D. (1974). Structural and biochemical characteristics of mast cells. In: Zweifach, B.W., Grant, L. and McCluskey, R.T. (eds). The inflammatory process. Volume 1, 2nd Ed. Academic Press, Inc.: New York, pp 545-599.
6. BOWLER, S.D., SMITH, S.M. & LAVERCOMBE, P.S. (1993). Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects. Am. Rev. Respir. Dis., 147, 160-163.
7. BRUSASCO, V., CRIMI, E. & PELLEGRINO, R. (1998). Airway hyperresponsiveness in asthma: not just a matter of airway inflammation. Thoras, 53, 992-998.
8. 1. Thromh. Res., 16, 507-516.
9. CLOWES, A.W. & KARNOVSKY, M.J. (1977). Suppression by heparin of smooth muscle cell proliferation in injured arteries. Nature, 256, 625-626.
10. CONRAD, H.E. (1989). Structure of heparan sulfate and dermatan sulfate. Ann. N.Y. Acad. Sci., 556, 18-28.
11. COYLE, A.J., PAGE, C.P., ATKINSON, L., FLANAGAN, R. & METZGER, W.J. (1990). The requirement for platelets in allergen-induced late asthmatic airway obstruction. Am. Rev. Respir. Dis., 142, 587-593.
12. COYLE, A.J., PAGE, C.P., ATKINSON, L., SJOERDSMA, K., TOUVAY, C. & METZGER, W.J. (1989). Modification of allergen-induced airway obstruction and airway hyperresponsiveness in an allergic rabbit model by the selective platelet-activating factor antagonist, BN 52021. J. Allergy Clin. Imimmol., 84, 960-967.
13. DIAMANT, Z., TIMMERS, M.C, VAN DER VEEN, H., PAGE, C.P., VAN DER MEER, F.J. & STERK, P.J. (1996). Effect of inhaled hcparin on allergen-induced early and late asthmatic responses in patients with atopic asthma. Am. J. Respir. Crit. Care Med., 153, 1790-1795.
14. DOLOWITZ, D.A. & DOUGHERTY, T.F. (1965). The use of heparin in the control of allergies. Ann. Allergy, 23, 309-313.
15. FLECKNALL, P.A. (1987). Anaesthesia of common laboratory species: special considerations. In: Flecknall, P.A. (ed.). Laboratory animal anaesthesia: an introduction for research workers and technicians. Academic Press: London, U.K., pp 98-100.
16. GREEN, W.F., KONNARIS, K. & WOOLCOCK, A.J. (1993). Effect of salbutamol, fenoterol, and sodium cromoglycate on the release of heparin from sensitized human lung fragments challenged with Dermatophagoides pteronyssinus allergen. Am. J. Respir. Cell Mol. Biol., 8, 518-521.
17. HARVIMA, R.J. & SCHWARTZ, L.B. (1993). Mast cell-derived mediators. In: Foreman, J.C. (ed.). The handbook of immunopharmacology: immunopharmacology of mast cells and basophils. Academic Press Ltd: London, pp 115-138.
18. HERD, C.M., DONIGI-GALE, D., SHOUPE, T.S., BURROUGHS, D.A., YEADON, M. & PAGE, C.P. (1994). Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. Br. J. Pharmacol., 112, 292-298.
19. HERD, C.M., GOZZARD, N. & PAGE, C.P. (1995). Capsaicin pretreatment prevents the development of antigen-induced airway hyperresponsiveness in neonatally immunised rabbits. Eur. J. Pharmacol., 282, 111-119.
20. HIRSCH, G.M. & KARNOVSKY, M.J. (1991). Inhibition of vein graft intimal proliferate lesions in the rat by heparin. Am. J. Pathol., 139, 581-587.
21. HOOK, M., KJELLEN, L., JOHANSSON, S. & ROBINSON, J. (1984). Cell surface glycosaminoglycans. Ann. Rev. Biochem., 53, 847-869.
22. LARSEN, G.L., WILSON, M.C., CLARK, R.A.F. & BEHRENS, B.L. (1987). The inflammatory reaction in the airways in an animal model of the late asthmatic response. Fed. Proc., 46, 105-112.
23. LASSER, E.C., SIMON, R.A., LYON, S.G., HAMBLIN, A.E. & STEIN, R. (1987). Hoparin-like anticoagulants and asthma. Allergy, 42, 619-625.
24. LÖTVALL, J., INMAN, M. & O'BYRNE, P. (1998). Measurement of airway hyperresponsiveness: new considerations. Thorax, 53, 419-424.
25. MINSHALL, E.M., RICCIO, M.M., HERD, C.M., DOUGLAS, G.J., SEEDS, E.A.M., McKENNIFF, M.G., SASAKI, M., SPINA, D. & PAGE, C.P. (1993). A novel animal model for investigating persistent airway hyperresponsiveness. J. Pharmacol. Toxicol. Meth., 30, 177-188.
26. O'DONNELL, W.J., ROSENBERG, M.A., KELLEHER, K., DRAZEN, J.M. & ISRAEL, E. (1992). Inhaled heparin does not protect asthmatics against antigen-induced bronchoconstriction. Am. Rev. Respir. Dis., 145, A422.
27. PAGE, C.P. & MINSHALL, E. (1993). Mast cells and the lung. In: Foreman, J.C. (ed.). The handbook of immunopharmacology: immunopharmarologv of mast cells and basophils. Academic Press Ltd: London, pp 181-195.
28. PAVORD, I., MUDASSAR, T., BENNEET, J., WILDING, P. & KNOX, A. (1996). The effect of inhaled heparin on bronchial reactivity to sodium metabisulphite and methacholine in patients with asthma. Eur. Rcspir. J., 9, 217-219.
29. PINCKARD, R.N., HALONEN, M. & MENG, A.L. (1972). Preferential expression of anti-bovine serum albumin IgE homocytotropic antibody synthesis and anaphylactic sensitivity in the neonatal rabbit. J. Allergy Clin. Immunol., 49, 301-310.
30. ROGERS, C., KARNOVSKY, M.J. & EDELMAN, E.R. (1993). Inhibition of experimental neointimal hyperplasia and thrombosis depends on the type of vascular injury and the site of drug administration. Circulation, 88, 1215-1221.
31. SASAKI, S. (1967). Production of lymphocytosis by polysaccharide polyphosphates (heparinoids). Nature, 214, 1041-1042.
32. SASAKI, M., HERD, C.M. & PAGE, C.P. (1993). Effect of heparin and a low-molecular weight heparinoid on PAF-induced airway responses in neonatally immunized rabbits. Br. J. Pharmacol., 110, 107-112.
33. SEEDS, E.A.M., HANSS, J. & PAGE, C.P. (1993). The effect of heparin and related proteoglycans on allergen and PAF-induced eosinophil infiltration. J. Lipid. Med., 1, 269-278.
34. SEEDS, E.A.M., HORNE, A.P., TYRELL, D.J. & PAGE, C.P. (1995). The effect of inhaled heparin and related glycosaminoglycans on allergen-induced eosinophil infiltration in guinea-pigs. Pulmon. Pharmacol., 8, 97-105.
35. SELYE, H. (1965). The mast cells. Butterworths Inc., Washington D.C.
36. SHAMPAIN, M.P., BEHRENS, B.L., LARSEN, G.L. & HENSON, P.M. (1982). An animal model of late pulmonary responses to Alternaria challenge. Am. Rev. Respir. Dis., 126, 493-498.
37. TANAKA, Y., ADAMS, D.H., HUBSCHER, S., HIRANO, H., SIEBENLIST, U. & SHAW, S. (1993a). T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β. Nature, 361, 79-82.
38. TANAKA, Y., ADAMS, D.H. & SHAW, S. (1993b). Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes. Immunol. Today, 14, 111-115.
39. TYRRELL, D.J., KILFEATHER, S. & PAGE, C.P. (1995). Therapeutic uses of heparin beyond its traditional role as an anticoagulant. Tr. Pharmacol. Sci., 16, 198-204.
40. VAN DER CARR, F.R. & WILLIAMS, O.B. (1928). Further studies on the influence of heparin on anaphylactic shock in the guinea pig. J. Immunol., 15, 13-20.
41. WEERSINK, E.J.M., POSTMA, D.S., AALBERS, R. & DEMONCHY, J.G.R. (1994). Early and late asthmatic reaction after allergen challenge. Respir. Med., 88, 103-114.