Symptomatic and functional remission of subjects at clinical high risk for psychosis: A 2-year naturalistic observational study

Schizophrenia Research

Volumn 156, Issue 2-3, 2014, Pages 266-271

  Lee, Tae Young ^a,b   Kim, Sung Nyun ^b,c   Correll, Christoph U ^d,e   Byun, Min Soo ^b,c   Kim, Euitae ^c,f   Jang, Joon Hwan ^c   Kang, Do Hyung ^c   Yun, Je Yeon ^c   Kwon, Jun Soo ^a,b,c  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d ZUCKER HILLSIDE HOSPITAL   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f Seoul National University Bundang Hospital   (South Korea)

Author keywords

Antipsychotics; Clinical high risk for psychosis; Functioning; Nonconverters; Stringent remission criteria

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CHLORPROMAZINE; MOOD STABILIZER; NEUROLEPTIC AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG USE; FEMALE; FOLLOW UP; GLOBAL ASSESSMENT OF FUNCTIONING; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; OBSERVATIONAL STUDY; POSITIVE SYNDROME; PRIORITY JOURNAL; PSYCHOSIS; REMISSION; SCALE OF PRODROMAL SYMPTOMS; COHORT ANALYSIS; DISEASE COURSE; PRODROMAL SYMPTOM; PROGNOSIS; PSYCHOLOGICAL RATING SCALE; PSYCHOTIC DISORDERS; RISK; SURVIVAL; TIME; TREATMENT OUTCOME; YOUNG ADULT;

ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; CHLORPROMAZINE; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; PRODROMAL SYMPTOMS; PROGNOSIS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; REMISSION INDUCTION; RISK; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84901833175     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2014.04.002     Document Type: Article

References (43)

1. Addington J., Cornblatt B.A., Cadenhead K.S., Cannon T.D., McGlashan T.H., Perkins D.O., Seidman L.J., Tsuang M.T., Walker E.F., Woods S.W., Heinssen R. At clinical high risk for psychosis: outcome for nonconverters. Am. J. Psychiatry 2011, 168(8):800-805.
2. Annett M. The binomial distribution of right, mixed and left handedness. Q. J. Exp. Psychol. 1967, 19(4):327-333.
3. Auther A., Smith C., Cornblatt B. Global Functioning: Social Scale (GF: Social) 2006, Zucker-Hillside Hospital, Glen Oaks, NY.
4. Cannon T.D., Cadenhead K., Cornblatt B., Woods S.W., Addington J., Walker E., Seidman L.J., Perkins D., Tsuang M., McGlashan T., Heinssen R. Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch. Gen. Psychiatry 2008, 65(1):28-37.
5. Cornblatt B.A., Lencz T., Smith C.W., Olsen R., Auther A.M., Nakayama E., Lesser M.L., Tai J.Y., Shah M.R., Foley C.A., Kane J.M., Correll C.U. Can antidepressants be used to treat the schizophrenia prodrome? Results of a prospective, naturalistic treatment study of adolescents. J. Clin. Psychiatry 2007, 68(4):546-557.
6. Cornblatt B.A., Carrion R.E., Addington J., Seidman L., Walker E.F., Cannon T.D., Cadenhead K.S., McGlashan T.H., Perkins D.O., Tsuang M.T., Woods S.W., Heinssen R., Lencz T. Risk factors for psychosis: impaired social and role functioning. Schizophr. Bull. 2012, 38(6):1247-1257.
7. Correll C.U., Hauser M., Auther A.M., Cornblatt B.A. Research in people with psychosis risk syndrome: a review of the current evidence and future directions. J. Child Psychol. Psychiatry 2010, 51(4):390-431.
8. Demjaha A., Valmaggia L., Stahl D., Byrne M., McGuire P. Disorganization/cognitive and negative symptom dimensions in the at-risk mental state predict subsequent transition to psychosis. Schizophr. Bull. 2012, 38(2):351-359.
9. Emsley R., Chiliza B., Asmal L., Lehloenya K. The concepts of remission and recovery in schizophrenia. Curr. Opin. Psychiatry 2011, 24:114-121.
10. Fusar-Poli P., Bonoldi I., Yung A.R., Borgwardt S., Kempton M.J., Valmaggia L., Barale F., Caverzasi E., McGuire P. Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Arch. Gen. Psychiatry 2012, 69(3):220-229.
11. Fusar-Poli P., Bechdolf A., Taylor M.J., Bonoldi I., Carpenter W.T., Yung A.R., McGuire P. At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk. Schizophr. Bull. 2013, 39(4):923-932.
12. Fusar-Poli P., Borgwardt S., Bechdolf A., Addington J., Riecher-Rossler A., Schultze-Lutter F., Keshavan M., Wood S., Ruhrmann S., Seidman L.J., Valmaggia L., Cannon T., Velthorst E., De Haan L., Cornblatt B., Bonoldi I., Birchwood M., McGlashan T., Carpenter W., McGorry P., Klosterkotter J., McGuire P., Yung A. The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry 2013, 70(1):107-120.
13. Gardner D.M., Murphy A.L., O'Donnell H., Centorrino F., Baldessarini R.J. International consensus study of antipsychotic dosing. Am. J. Psychiatry 2010, 167(6):686-693.
14. Gershon E.S., Guroff J.J. Information from relatives. Diagnosis of affective disorders. Arch. Gen. Psychiatry 1984, 41(2):173-180.
15. Hall R.C. Global assessment of functioning. A modified scale. Psychosomatics 1995, 36(3):267-275.
16. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 1960, 23:56-62.
17. Hollingshead A. Four Factor Index of Social Status 1975, Yale University Department of Psychology, New Haven.
18. Jang J.H., Shin N.Y., Shim G., Park H.Y., Kim E., Jang G.E., Kwon S.J., Hur J.W., An S.K., Kwon J.S. Longitudinal patterns of social functioning and conversion to psychosis in subjects at ultra-high risk. Aust. N. Z. J. Psychiatry 2011, 45(9):763-770.
19. Jung M.H., Jang J.H., Kang D.H., Choi J.S., Shin N.Y., Kim H.S., An S.K., Shin M.S., Kwon J.S. The reliability and validity of the Korean version of the structured interview for prodromal syndrome. Psychiatry Invest. 2010, 7(4):257-263.
20. Kim E., Jang J.H., Park H.Y., Shim G., Hwang J.Y., Kim S.N., Kwon J.S. Pharmacotherapy and clinical characteristics of ultra-high-risk for psychosis according to conversion status: a naturalistic observational study. Early Interv. Psychiatry 2012, 6(1):30-37.
21. Klosterkotter J., Hellmich M., Steinmeyer E.M., Schultze-Lutter F. Diagnosing schizophrenia in the initial prodromal phase. Arch. Gen. Psychiatry 2001, 58(2):158-164.
22. Kwon J.S., Byun M.S., Lee T.Y., An S.K. Early intervention in psychosis: insights from Korea. Asian J. Psychiatry 2012, 5(1):98-105.
23. Lemos-Giráldez S., Vallina-Fernández O., Fernández-Iglesias P., Vallejo-Seco G., Fonseca-Pedrero E., Paíno-Piñeiro M., Sierra-Baigrie S., García-Pelayo P., Pedrejón-Molino C., Alonso-Bada S., Gutiérrez-Pérez A., Ortega-Ferrández J.A. Symptomatic and functional outcome in youth at ultra-high risk for psychosis: a longitudinal study. Schizophr. Res. 2009, 115(2-3):121-129.
24. McGlashan T.H., Zipursky R.B., Perkins D., Addington J., Miller T., Woods S.W., Hawkins K.A., Hoffman R.E., Preda A., Epstein I., Addington D., Lindborg S., Trzaskoma Q., Tohen M., Breier A. Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis. Am. J. Psychiatry 2006, 163(5):790-799.
25. McGorry P.D., Yung A.R., Phillips L.J., Yuen H.P., Francey S., Cosgrave E.M., Germano D., Bravin J., McDonald T., Blair A., Adlard S., Jackson H. Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch. Gen. Psychiatry 2002, 59(10):921-928.
26. McGorry P.D., Hickie I.B., Yung A.R., Pantelis C., Jackson H.J. Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions. Aust. N. Z. J. Psychiatry 2006, 40(8):616-622.
27. Miller T.J., McGlashan T.H., Rosen J.L., Somjee L., Markovich P.J., Stein K., Woods S.W. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. Am. J. Psychiatry 2002, 159(5):863-865.
28. Nieman D.H., Ruhrmann S., Dragt S., Soen F., van Tricht M.J., Koelman J.H.T.M., Bour L.J., Velthorst E., Becker H.E., Weiser M., Linszen D.H., de Haan L. Psychosis prediction: stratification of risk estimation with information-processing and premorbid functioning variables. Schzophr. Bull. 2013, 10.1093/schbul/sbt145.
29. Niendam T., Bearden C., Johnson J., Cannon T. Global Functioning: Role Scale (GF: Role) 2006, University of California, Los Angeles, Los Angeles, CA.
30. Ruhrmann S., Schultze-Lutter F., Salokangas R.K., Heinimaa M., Linszen D., Dingemans P., Birchwood M., Patterson P., Juckel G., Heinz A., Morrison A., Lewis S., von Reventlow H.G., Klosterkotter J. Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Arch. Gen. Psychiatry 2010, 67(3):241-251.
31. Schlosser D.A., Jacobson S., Chen Q., Sugar C.A., Niendam T.A., Li G., Bearden C.E., Cannon T.D. Recovery from an at-risk state: clinical and functional outcomes of putatively prodromal youth who do not develop psychosis. Schizophr. Bull. 2012, 38(6):1225-1233.
32. Shim G., Kang D.H., Choi J.S., Jung M.H., Kwon S.J., Jang G.E., Kwon J.S. Prospective outcome of early intervention for individuals at ultra-high-risk for psychosis. Early Interv. Psychiatry 2008, 2(4):277-284.
33. Simon A.E., Umbricht D. High remission rates from an initial ultra-high risk state for psychosis. Schizophr. Res. 2010, 116(2-3):168-172.
34. Simon A.E., Borgwardt S., Riecher-Rossler A., Velthorst E., de Haan L., Fusar-Poli P. Moving beyond transition outcomes: meta-analysis of remission rates in individuals at high clinical risk for psychosis. Psychiatry Res. 2013, 209(3):266-272.
35. Stafford M.R., Jackson H., Mayo-Wilson E., Morrison A.P., Kendall T. Early interventions to prevent psychosis: systematic review and meta-analysis. BMJ 2013, 346:f185.
36. Valenstein M., Copeland L.A., Blow F.C., McCarthy J.F., Zeber J.E., Gillon L., Bingham C.R., Stavenger T. Pharmacy data identify poorly adherent patients with schizophrenia at increased risk for admission. Med. Care 2002, 40(8):630-639.
37. Valmaggia L.R., Stahl D., Yung A.R., Nelson B., Fusar-Poli P., McGorry P.D., McGuire P.K. Negative psychotic symptoms and impaired role functioning predict transition outcomes in the at-risk mental state: a latent class cluster analysis study. Psychol. Med. 2013, 43(11):2311-2315.
38. van der Gaag M., Smit F., Bechdolf A., French P., Linszen D.H., Yung A.R., McGorry P., Cuijpers P. Preventing a first episode of psychosis: meta-analysis of randomized controlled prevention trials of 12month and longer-term follow-ups. Schizophr. Res. 2013, 149(1-3):56-62.
39. Velthorst E., Nieman D.H., Linszen D., Becker H., de Haan L., Dingemans P.M., et al. Disability in people clinically at high risk of psychosis. Br. J. Psychiatry 2010, 197(4):278-284.
40. Yum T., Park Y., Oh K., Kim J., Lee Y. The manual of Korean-Wechsler adult intelligence scale 1992, Korea Guidance, Seoul.
41. Yung A.R., Phillips L.J., Yuen H.P., McGorry P.D. Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr. Res. 2004, 67(2-3):131-142.
42. Yung A.R., Yuen H.P., Berger G., Francey S., Hung T.C., Nelson B., Phillips L., McGorry P. Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk?. Schizophr. Bull. 2007, 33(3):673-681.
43. Ziermans T.B., Schothorst P.F., Sprong M., van Engeland H. Transition and remission in adolescents at ultra-high risk for psychosis. Schizophr. Res. 2011, 126(1-3):58-64.