Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri

Modern Pathology

Volumn 27, Issue 6, 2014, Pages 851-862

  Folcik, Virginia A ^a,b,c   Garofalo, Michela ^d   Coleman, Jack ^e   Donegan, James J ^e   Rabbani, Elazar ^e   Suster, Saul ^f   Nuovo, Allison ^g   Magro, Cynthia M ^h   Di Leva, Gianpiero ^d   Nuovo, Gerard J ^d,i  

^a The Ohio State University at Marion   (United States)

^b Ohio State University   (United States)

^c and Engineered Systems ^*  (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e Enzon Incorporated   (United States)

^f MEDICAL COLLEGE OF WISCONSIN   (United States)

^g THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^h WEILL CORNELL MEDICAL CENTER   (United States)

ⁱ Phylogeny Inc   (United States)

Author keywords

cyclin D; herpesvirus saimiri; idiopathic pulmonary fibrosis; IL 17

Indexed keywords

CYCLIN D; DIHYDROFOLATE REDUCTASE; DNA POLYMERASE; INTERLEUKIN 17; PARAFFIN; RNA; THYMIDYLATE SYNTHASE; VIRUS DNA;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DNA RNA HYBRIDIZATION; EPITHELIUM CELL; FEMALE; FIBROSING ALVEOLITIS; GENOME; HERPES SIMPLEX; HERPES VIRUS SAIMIRI; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LUNG BIOPSY; LUNG FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; AGED; COMPLICATION; HERPES VIRUS INFECTION; ISOLATION AND PURIFICATION; MIDDLE AGED; SAIMIRIINE HERPESVIRUS 2; VIROLOGY;

AGED; DNA, VIRAL; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 2, SAIMIRIINE; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84901833023     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.198     Document Type: Article

References (33)

1. Williams KJ, Maes R, Piero FD, et al. Equine multi-nodular pulmonary fibrosis: a newly recognized herpes-virus-associated fibrotic lung disease. Vet Path 2007; 44:849-862. (Pubitemid 350260705)
2. Kleiboeker SB, Schommer SK, Johnson PJ, et al. Association of two newly recognized herpesviruses with interstitial pneumonia in donkeys (Equus asinus). J Vet Diagn Invest 2002;14:273-280. (Pubitemid 135746050)
3. Virgin HW, LaTreille P, Wamsley P, et al. Complete sequence and genomic analysis of murine gammaher-pesvirus 68. J Virol 1997;71:5894-5904. (Pubitemid 27304926)
4. Mora AL, Woods CR, Garcia A, et al. Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice. Am J Physiol Lung Cell Mol Physiol 2005;289:L711-L721. (Pubitemid 41504401)
5. Mora AL, Torres-Gonzales E, Rojas M, et al. Control of virus reactivation arrests pulmonary herpesvirus-in-duced fibrosis in IFN-g receptor-deficient mice. Am J Respir Crit Care Med 2007;175:1139-1150. (Pubitemid 46855455)
6. Fickenscher H, Fleckenstein B. Herpesvirus saimiri. Phil Trans Royal Soc London B 2001;356:545-567. (Pubitemid 32442752)
7. Simmer B, Alt M, Buckreus I, et al. Persistence of selectable herpesvirus saimiri in various human haematopoietic and epithelial cell lines. J Gen Virol 1991;72:1953-1958.
8. Biesinger B, Muller-Fleckenstein I, Simmer B, et al. Stable growth transformation of human T lymphocytes by Herpesvirus saimiri. Proc Natl Acad Sci USA 1992; 89:3116-3119.
9. Smith PG, Burchill SA, Brooke D, et al. Efficient infection and persistence of a herpesvirus saimiri-based gene delivery vector into human tumor xeno-graphs and multicellular spheroid cultures. Cancer Gene Ther 2005;12:248-256. (Pubitemid 40315184)
10. Jung JU, Trimble JJ, King NW, et al. Identification of transforming genes of subgroup A and C strains of Herpesvirus Saimiri. Proc Natl Acad Sci USA 1991; 88:7051-7055. (Pubitemid 21915087)
11. Ablashi D, Dahlberg J, Cannon G, et al. Detection of antibodies to Herpesvirus saimiri late antigens in human sera. Intervirol 1988;29:217-226.
12. Yao Z, Fanslow WC, Seldin MF, et al. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995;3:811-821. (Pubitemid 26091152)
13. Rouvier E, Luciani M-F, Mattei M-G, et al. CTLA-8 cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a Herpesvirus Saimiri gene. J Immunol 1993;150:5445-5456. (Pubitemid 23180658)
14. Nicholas J, Cameron KR, Honess RW. Herpesvirus saimiri encodes homologues of G-protein-coupled receptors and cyclins. Nature 1992;355:362-365.
15. Bodemer W, Niller HH, Nitsche N, et al. Organization of the thymidylate synthase gene of herpesvirus saimiri. J Virol 1986;60:114-123. (Pubitemid 16003152)
16. Trimble JJ, Murthy SCS, Bakker A, et al. A gene for dihydrofolate reductase in a herpesvirus. Science 1988;239:1145-1147. (Pubitemid 18084324)
17. Olsen AL, Swigris JJ, Lezotte DC, et al. Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003. Am J Respir Crit Care Med 2007;176: 277-284. (Pubitemid 47195878)
18. Papiris SA, Manali ED, Kolilekas L, et al. Steroids in idiopathic pulmonary fibrosis acute exacerbation: defenders or killers? Am J Respir Crit Care Med 2012; 185:587-588.
19. IPFCRN. Prednisone, azathioprine, and N-acetylcys-teine for pulmonary fibrosis. N Engl J Med 2012;366: 1968-1977.
20. Cookson WOC, Moffatt MF. Bedside to gene and back in idiopathic pulmonary fibrosis. N Engl J Med 2013;368:2228-2230.
21. Nuovo GJ, Hagood JS, Magro CM, et al. The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis. Mod Pathol 2012;25:416-433.
22. Albrecht J-C, Nicholas J, Biller D, et al. Primary structure of the herpesvirus saimiri genome. J Virol 1992;66:5047-5058.
23. Nuovo GJ. In situ detection of microRNAs in paraffin embedded, formalin fixed tissues and the co-localization of their putative targets. Methods 2010;52:307-315.
24. Yasukawa M, Inoue Y, Kimura N, et al. Immortalization of human T cells expressing T-cell receptor gamma-delta by Herpesvirus Saimiri. J Virol 1995;69: 8114-8117.
25. Bankier AT, Dietrich W, Baer R, et al. Terminal repetetive sequences in herpesvirus saimiri virion DNA. J Virol 1985;55:133-139. (Pubitemid 15048699)
26. Jung JU, Stager M, Desrosiers RC. Virus-encoded cyclin. Mol Cell Biol 1994;14:7235-7244. (Pubitemid 24326388)
27. Honess RW, Bodemer W, Cameron KR, et al. The AT-rich genome of herpesvirus saimiri contains a highly conserved gene for thymidylate synthase. P Proc Natl Acad Sci USA 1986;83:3604-3608. (Pubitemid 16062333)
28. Tang Y-W, Johnson JE, Browning PJ, et al. Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J Clin Microbiol 2003;41:2633-2640. (Pubitemid 36712478)
29. Neyts J, De Clercq E. In vitro and in vivo inhibition of Murine Gamma Herpesvirus 68 replication by selected antiviral agents. Antimicrob Agents Chemother 1998; 42:170-172. (Pubitemid 28053346)
30. Hashemolhosseini S, Nagamine Y, Morley SJ, et al. Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J Biol Chem 1998;273:14424-14429. (Pubitemid 28319162)
31. Buschhausen L, Kamm M, Arns W, et al. Succssful treatment of a severe case of idiopathic pulmonary fibrosis with Rapamycin. Med Klinik 2005;100:161-164. (Pubitemid 40521580)
32. Korfhagen TR, Cras TDL, Davidson CR, et al. Rapamy-cin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 2009;41: 562-572.
33. Raghu G, Collard HR, Egan JJ, et al. American Thoracic Society Documents. An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 2011;183:788-824.