Chronic kidney disease reduces muscle mitochondria and exercise endurance and its exacerbation by dietary protein through inactivation of pyruvate dehydrogenase

Kidney International

Volumn 85, Issue 6, 2014, Pages 1330-1339

  Tamaki, Masanori ^a   Miyashita, Kazutoshi ^a   Wakino, Shu ^a   Mitsuishi, Masanori ^a   Hayashi, Koichi ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

chronic kidney disease; mitochondria; nutrition

Indexed keywords

DICHLOROACETIC ACID; PYRUVATE DEHYDROGENASE; AUTACOID; CYTOKINE; ENZYME ACTIVATOR; PROTEIN INTAKE; PYRUVATE DEHYDROGENASE COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME INACTIVATION; EXERCISE TOLERANCE; KIDNEY FAILURE; MALE; MOUSE; MUSCLE MASS; MUSCLE MITOCHONDRION; MUSCLE STRENGTH; MUSCLE WEAKNESS; NEPHRECTOMY; NONHUMAN; PATHOPHYSIOLOGY; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PROTEIN INTAKE; RUNNING; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; MITOCHONDRIAL DYNAMICS; OXIDATIVE STRESS; PATHOLOGY; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TIME;

ANIMALS; CYTOKINES; DICHLOROACETIC ACID; DIETARY PROTEINS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ENZYME ACTIVATORS; EXERCISE TOLERANCE; INFLAMMATION MEDIATORS; MALE; MICE, INBRED C57BL; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL TURNOVER; MUSCLE STRENGTH; MUSCLE, SKELETAL; OXIDATIVE STRESS; PYRUVATE DEHYDROGENASE COMPLEX; RENAL INSUFFICIENCY, CHRONIC; RUNNING; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84901830404     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.473     Document Type: Article

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