Evaluation of pulmonary dysfunctions and acid-base imbalances induced by Chlamydia psittaci in a bovine model of respiratory infection

Multidisciplinary Respiratory Medicine

Volumn 9, Issue 1, 2014, Pages

  Ostermann, Carola ^a   Linde, Susanna ^a   Siegling Vlitakis, Christiane ^b   Reinhold, Petra ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Acid base status; Animal model; Chlamydia psittaci; Pulmonary function

Indexed keywords

ALBUMIN; GLUCOSE; ION; LACTIC ACID;

ACID BASE BALANCE; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BLOOD PH; BREATHING MECHANICS; BREATHING RATE; CAPNOMETRY; CELL CULTURE; CHLAMYDOPHILA PSITTACI; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISORDERS OF ACID BASE BALANCE; EXPIRATORY FLOW; FUNCTIONAL RESIDUAL CAPACITY; GLUCOSE BLOOD LEVEL; HYPERVENTILATION; HYPOCAPNIA; HYPOCHLOREMIA; LACTATE BLOOD LEVEL; LUNG DEAD SPACE; LUNG DISEASE; LUNG FUNCTION TEST; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; NONHUMAN; OSCILLOMETRY; PROSPECTIVE STUDY; PULMONARY DYSFUNCTION; RESPIRATORY TRACT INFECTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TIDAL VOLUME; VENOUS BLOOD;

EID: 84901829810     PISSN: 1828695X     EISSN: 20496958     Source Type: Journal    
DOI: 10.1186/2049-6958-9-10     Document Type: Article

References (68)

1. Reinhold P, Sachse K, Kaltenboeck B: Chlamydiaceae in cattle: commensals, trigger organisms, or pathogens? Vet J 2011, 189:257-267.
2. Borel N, Thoma R, Spaeni P, Weilenmann R, Teankum K, Brugnera E, Zimmermann DR, Vaughan L, Pospischil A: Chlamydia-related abortions in cattle from Graubunden, Switzerland. Vet Pathol 2006, 43:702-708. (Pubitemid 44379946)
3. Twomey DF, Griffiths PC, Horigan MW, Hignett BC, Martin TP: An investigation into the role of Chlamydophila spp. in bovine upper respiratory tract disease. Vet J 2006, 171:574-576. (Pubitemid 46137371)
4. Kauffold J, Henning K, Bachmann R, Hotzel H, Melzer F: The prevalence of chlamydiae of bulls from six bull studs in Germany. Anim Reprod Sci 2007, 102:111-121. (Pubitemid 47332943)
5. Pantchev A, Sting R, Bauerfeind R, Tyczka J, Sachse K: Detection of all Chlamydophila and Chlamydia spp. of veterinary interest using species-specific real-time PCR assays. Comp Immunol Microb 2010, 33:473-484.
6. Kemmerling K, Müller U, Mielenz M, Sauerwein H: Chlamydophila species in dairy farms: polymerase chain reaction prevalence, disease association, and risk factors identified in a cross-sectional study in western Germany. J Dairy Sci 2009, 92:4347-4354.
7. Reinhold P, Ostermann C, Liebler-Tenorio E, Berndt A, Vogel A, Lambertz J, Rothe M, Rüttger A, Schubert E, Sachse K: A bovine model of respiratory Chlamydia psittaci infection: challenge dose titration. PloS One 2012, 7:e30125.
8. Ballard-Croft C, Wang DF, Sumpter LR, Zhou XQ, Zwischenberger JB: Large- Animal models of Acute Respiratory Distress Syndrome. Ann Thorac Surg 2012, 93:1331-1339.
9. Ireland JJ, Roberts RM, Palmer GH, Bauman DE, Bazer FW: A commentary on domestic animals as dual-purpose models that benefit agricultural and biomedical research. J Anim Sci 2008, 86:2797-2805.
10. Haas WH, Swaan CM, Meijer A, Neve G, Buchholz U, Beer M, van Steenbergen JE, Krause G: A Dutch case of atypical pneumonia after culling of H5N1 positive ducks in Bavaria was found infected with Chlamydophila psittaci. Euro Surveill 2007, 12, E071129.3.
11. Petrovay F, Balla E: Two fatal cases of psittacosis caused by Chlamydophila psittaci. J Med Microbiol 2008, 57:1296-1298.
12. Fraeyman A, Boel A, Van Vaerenbergh K, De Beenhouwer H: Atypical pneumonia due to Chlamydophila psittaci: 3 case reports and review of literature. Acta Clin Belg 2010, 65:192-196.
13. Theegarten D, Sachse K, Mentrup B, Fey K, Hotzel H, Anhenn O: Chlamydophila spp. infection in horses with recurrent airway obstruction: similarities to human chronic obstructive disease. Respir Res 2008, 9:14.
14. Theegarten D, Anhenn O, Hotzel H, Wagner M, Marra A, Stamatis G, Mogilevski G, Sachse K: A comparative ultrastructural and molecular biological study on Chlamydia psittaci infection in alpha-1 antitrypsin deficiency and non-alpha-1 antitrypsin deficiency emphysema versus lung tissue of patients with hamartochondroma. BMC Infect Dis 2004, 4:38.
15. Jaeger J, Liebler-Tenorio E, Kirschvink N, Sachse K, Reinhold P: A clinically silent respiratory infection with Chlamydophila spp. in calves is associated with airway obstruction and pulmonary inflammation. Vet Res 2007, 38:711-728. (Pubitemid 350043446)
16. Stewart PA: Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983, 61:1444-1461.
17. Constable PD: A simplified strong ion model for acid-base equilibria: application to horse plasma. J ApplPhysiol 1997, 83:297-311.
18. Bovarnick MR, Miller JC, Snyder JC: The influence of certain alts, amino acids, sugars, and proteins on the stability of rickettsiae. J Bacteriol 1950, 59:509-522.
19. Kneucker A, Langenberg A, Smith HJ, Reinhold P: Functional residual capacity and lung diffusion capacity in calves with chronic airflow obstruction caused by persistent chlamydial infection [abstract]. Eur Respir J 2008, 32(Suppl 52):4070.
20. Reinhold P, Reissig S, Jaeger J, Langenberg A, Smith HJ: Capnovolumetry is a useful technique to detect peripheral airway obstruction [abstract]. Eur Respir J 2007, 58(Suppl 51):233.
21. Reinhold P, Smith HJ, Close R, Genicot B, Lekeux P: Validation of impulse oscillometry in Friesian and Blue Belgian calves with respect to changes in extrathoracic upper airway resistance. Res Vet Sci 1998, 65: 93-101.
22. Reinhold P, Smith HJ, Langenberg A, Lekeux P: Measurement of respiratory impedance in healthy calves using the impulse oscillation technique - Physiological and methodological aspects. Vet J 1998, 155: 27-38. (Pubitemid 128679217)
23. Smith H, Reinhold P, Goldman M: Forced oscillation technique and impulse oscillometry. Eur Respir Mon 2005, 31:72-105.
24. Oh MS, Carroll HJ: The anion gap. New Engl J Med 1977, 297:814-817. (Pubitemid 8194805)
25. Constable PD, Hinchcliff KW, Muir WW 3rd: Comparison of anion gap and strong ion gap as predictors of unmeasured strong ion concentration in plasma and serum from horses. Am J Vet Res 1998, 59:881-887. (Pubitemid 128472045)
26. Constable PD: Clinical assessment of acid-base status: comparison of the Henderson-Hasselbalch and strong ion approaches. Vet Clin Pathol 2000, 29:115-128.
27. Reinhold P, Hartmann H, Constable PD: Characterisation of acid-base abnormalities in pigs experimentally infected with Chlamydia suis. Vet J 2010, 184:212-218.
28. Constable PD, Stämpfli HR, Navetat H, Berchtold J, Schelcher F: Use of a quantitative strong ion approach to determine the mechanism for acid-base abnormalities in sick calves with or without diarrhea. J Vet Intern Med 2005, 19:581-589. (Pubitemid 41127519)
29. Constable PD, Stämpfli HR: Experimental determination of net protein charge and A(tot) and K(a) of nonvolatile buffers in canine plasma. J Vet Intern Med 2005, 19:507-514. (Pubitemid 41127507)
30. Kellum JA, Kramer DJ, Pinsky MR: Strong ion gap: a methodology for exploring unexplained anions. J Crit Care 1995, 10:51-55.
31. Reeves RB: Temperature-induced changes in blood acid-base status: pH and PCO2 in a binary buffer. J Appl Physiol 1976, 40:752-761.
32. de Morais HSA: A nontraditional approach to acid-base disorders. In Fluid Therapy in Small Animal Practice. Edited by DiBartola SP. Philadelphia: Saunders (W.B.); 1992:297-320.
33. Whitehair KJ, Haskins SC, Whitehair JG, Pascoe PJ: Clinical applications of quantitative acid-base chemistry. J Vet Intern Med 1995, 9:1-11.
34. Funk GC: [Stewart's acid-base approach] german. Wien Klin Wochenschr 2007, 119:390-403.
35. Gibbons JD: Nonparametric Statistical Inference. 2nd edition. New York and Basel: Marcel Dekker, Inc.; 1985.
36. Hollander M, Wolfe DA: Nonparametric Statistical Methods. New York-Sydney-Tokyo-Mexico City: John Wiley & Sons; 1973.
37. Kirschvink N, Reinhold P: Use of alternative animals as asthma models. Curr Drug Targets 2008, 9:470-484. (Pubitemid 352025204)
38. Ostermann C, Rüttger A, Schubert E, Schrodl W, Sachse K, Reinhold P: Infection, disease, and transmission dynamics in calves after experimental and natural challenge with a bovine Chlamydia psittaci isolate. PloS One 2013, 8(5):e64066.
39. Cunha BA: The atypical pneumonias: clinical diagnosis and importance. Clin Microbiol Infect 2006, 12(Suppl 3):12-24.
40. Ostermann C, Schroedl W, Schubert E, Sachse K, Reinhold P: Dose-dependent effects of Chlamydia psittaci infection on pulmonary gas exchange, innate immunity and acute-phase reaction in a bovine respiratory model. Vet J 2013, 196:351-359.
41. Glaab T, Taube C, Braun A, Mitzner W: Invasive and noninvasive methods for studying pulmonary function in mice. Respir Res 2007, 8:63.
42. Hoymann HG: Lung function measurements in rodents in safety pharmacology studies. Front Pharmacol 2012, 3:156.
43. Lambertz J: [Pathology and pathogenesis of an experimental aerogenous infection of calves with Chlamydophila psittaci (non-avian origin)], Thesis (german). Tierärztliche Hochschule Hannover; 2011. http://elib. tihohannover.de/dissertations/lambertzj-ss11.pdf.
44. Reinhold P, Langenberg A, Lekeux P: [Review of respiratory mechanics in animals. 4. The diagnostic affirmation ability of research using the impulse oscilloresistometry system (IOS) in calves] german. Berl Münch Tierärztl Wochenschr; 1998:262-267.
45. Short PM, Williamson PA, Lipworth BJ: Sensitivity of impulse oscillometry and spirometry in beta-blocker induced bronchoconstriction and beta-agonist bronchodilatation in asthma. Ann Allergy Asthma Immunol 2012, 109:412-415.
46. Gallivan GJ, Mcdonell WN: An evaluation of the Multiple-Breath Nitrogen Washout as a Pulmonary-Function Test in dairy-cattle. Can J Vet Res 1989, 53:133-142.
47. Gallivan GJ, Viel L, Baird JD, Mcdonell WN: Pulmonary structure and function in adult dairy-cows with an expanded lung field. Can J Vet Res 1991, 55:15-20.
48. Caswett J, Williams K: Respiratory System. In Jubb, Kennedy & Palmer's Pathology of Domestic Animals, Volume 2. 5th edition. Edited by Maxie MG. London, UK: Elsevier; 2007:523-653.
49. Reinhold P, Kirschvink N, Theegarten D, Berndt A: An experimentally induced Chlamydia suis infection in pigs results in severe lung function disorders and pulmonary inflammation. Vet Res 2008, 39: 35.
50. Weiss SG, Newcomb RW, Beem MO: Pulmonary assessment of children after Chlamydial Pneumonia of infancy. J Pediatr 1986, 108: 659-664. (Pubitemid 16064105)
51. Horwitz AE: [Imaging methods in airway and lung diseases of children - conventional diagnostics] german. Atemw-Lungenkrkh 2010, 36:266-279.
52. Jupelli M, Murthy AK, Chaganty BKR, Guentzel MN, Selby DM, Vasquez MM, Mustafa SB, Henson BM, Seidner SR, Zhong GM, Arulanandam BP: Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life. Lab Invest 2011, 91:1530-1539.
53. Metz G, Kraft M: Effects of atypical infections with Mycoplasma and Chlamydia on asthma. Immunol Allergy Clin North Am 2010, 30:575-585. vii-viii.
54. Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, Bonini S, Bont L, Bossios A, Bousquet J, Braido F, Brusselle G, Canonica GW, Carlsen KH, Chanez P, Fokkens WJ, Garcia-Garcia M, Gjomarkaj M, Haahtela T, Holgate ST, Johnston SL, Konstantinou G, Kowalski M, Lewandowska-Polak A, Lødrup-Carlsen K, Mäkelä M, Malkusova I, Mullol J, Nieto A, Eller E, et al: Viruses and bacteria in acute asthma exacerbations-a GA(2) LEN-DARE systematic review. Allergy 2011, 66: 458-468.
55. Mercer RR, Russell ML, Crapo JD: Alveolar septal structure in different species. J Appl Physiol 1994, 77:1060-1066. (Pubitemid 24299352)
56. Spörri H, Zerobin K: [About the physiology and methodology of pulmonary function tests] german. Tierärztl Umschau 1964, 19: 285-292.
57. Reinhold P, Steinbach G, Langenberg A, Lekeux P: [Review of respiratory mechanics in animals. 3. Methodical and physiologic aspects of the use of the impulse oscilloresistometry system (IOS)] german. Berl Münch Tierärztl Wochenschr 1998, 111:253-261.
58. Lekeux P, Hajer R, Breukink HJ: Effect of somatic growth on pulmonary-function values in healthy friesiancattle. Am J Vet Res 1984, 45: 2003-2007. (Pubitemid 15206297)
59. Gustin P, Bakima M, Art T, Lekeux P, Lomba F, van de Woestijne KP: Pulmonary function values and growth in Belgian white and blue double-muscled cattle. Res Vet Sci 1988, 45:405-410.
60. Castleman WL, Lay JC: Morphometric and ultrastructural-study of postnatal lung growth and development in calves. Am J Vet Res 1990, 51: 789-795.
61. Bachmann L: [Suitability of the Stewart variables of acid-base status in the analysis of processes in the abomasum and blood of calves on differing diets], Thesis (german). Berlin: Freie Universität Berlin; 2008. http://www.diss.fu-berlin.de/diss/servlets/MCRFileNodeServlet/ FUDISS-derivate-000000004071/bachm.pdf?hosts.
62. Constable PD: Calculation of variables describing plasma nonvolatile weak acids for use in the strong ion approach to acid-base balance in cattle. Am J Vet Res 2002, 63:482-490.
63. Elkhair NM, Siegling-Vlitakis C, Radtke E, Willing A, Hartmann H: Age-dependent response of the acid-base parameters (Henderson-Hasselbalch, Stewart) in healthy calves with experimentally induced metabolic acidosis. Berl Münch Tierärztl Wochenschr 2009, 122:63-69.
64. Wall RE: Respiratory acid-base disorders. Vet Clin North Am Small Anim Pract 2001, 31:1355-1367. viii.
65. Haskins SC: An overview of acid-base physiology. J American Vet Med Assoc 1977, 170:423-428.
66. Kellum JA: Determinants of blood pH in health and disease. Crit Care 2000, 4:6-14.
67. Poudel A, Elsasser TH, Rahman KS, Chowdhury EU, Kaltenboeck B: Asymptomatic endemic Chlamydia pecorum infections reduce growth rates in calves by up to 48 percent. PLoS One 2012, 7(9):e44961.
68. Madias NE, Adrogue HJ: Cross-talk between two organs: how the kidney responds to disruption of acid-base balance by the lung. Nephron Physiol 2003, 93:61-66.